Esan or ESAN may refer to:

• Esan people, an ethnic group of southern Nigeria
• Esan language, an Edoid language spoken by the Esan people
• Esanland, a cultural region and senatorial district of Nigeria, where the Esan people live
• Esan, Hokkaido, a former town in Japan now part of Hakodate, Hokkaido
• Mount Esan, a volcano in Hakodate, Hokkaido
• ESAN University, a university in Lima, Peru

• Issac Moore
• Issac Moore (settler)
• Issac Morales
• Issac Morier
• Issac Morley
• Issac Moses
• Issac Motte
• Issac Muleme
• Issac Munuswamy Poobalan
• Issac Murphy
• Issac Murphy Award
• Issac Mustafin
• Issac Musumba
• Issac M. Wise Temple
• Issac (name)
• Issac Nana Asare
• Issac N. Arnold
• Issac Nathan
• Issac N. Brown
• Issac N. Carleton
• Issac N. Comstock
• Issac N. Cox
• Issac Nettles Gravestones
• Issac Neuberger House
• Issac Newton (agriculturalist)