Esplen may refer to:

• Esplen (Pittsburgh)
• Esplen baronets
• John Esplen

• Quadrirectified 10-orthoplex
• Quadrirectified 10-simplex
• Quadrirectified 4 21 polytope
• Quadrirectified 8-cubic honeycomb
• Quadrirectified 9-cube
• Quadrirectified 9-simplex
• Quadri riportati
• Quadrisecant
• Quadriserv
• Quadrispora
• Quadrisporites
• Quadristruma
• Quadritone
• Quadritruncated 7-cubic honeycomb
• Quadritruncated 8-cube
• Quadrivalent vaccine
• Quadriviridae
• Quadrivirus
• Quadro FX 4500
• Quadro FX 5600
• Quadro GPU
• Quadrologue at Utopia
• Quadron (Album)
• Quadron (album)
• Quadrone