| 词条 | Exonuclease VII |
| 释义 |
| Symbol = Exonuc_VII_L | Name = Exonuclease VII, large subunit | image = | width = | caption = | Pfam = PF02601 | Pfam_clan = | InterPro = IPR020579 | SMART = | PROSITE = | MEROPS = | SCOP = | TCDB = | OPM family = | OPM protein = | CAZy = | CDD = }}{{Infobox protein family | Symbol = Exonuc_VII_S | Name = Exonuclease VII small subunit | image = PDB 1vp7 EBI.jpg | width = | caption = crystal structure of exodeoxyribonuclease vii small subunit (np_881400.1) from bordetella pertussis at 2.40 a resolution | Pfam = PF02609 | Pfam_clan = | InterPro = IPR003761 | SMART = | PROSITE = | MEROPS = | SCOP = | TCDB = | OPM family = | OPM protein = | CAZy = | CDD = }} In molecular biology, exonuclease VII ({{EC number|3.1.11.6}}, Escherichia coli exonuclease VII, E. coli exonuclease VII, endodeoxyribonuclease VII, Exodeoxyribonuclease VII) is a bacterial exonuclease enzyme.[1][2] It is composed of two nonidentical subunits; one large subunit and 4 small ones.[3] Exonuclease VII catalyses exonucleolytic cleavage in either 5'-3' or 3'-5' direction to yield 5'-phosphomononucleotides. The large subunit also contains an N-terminal OB-fold domain that binds to nucleic acids. References1. ^{{cite journal | title = Ribonuclease VII of Escherichia coli |author1 = Chase, J.W. |author2 =Richardson, C.C. |journal = J. Biol. Chem. |year = 1974 |volume = 249 |pages = 4545–4552 |pmid = 4602029 | issue = 14}} {{InterPro content|IPR020579}}{{InterPro content|IPR003761}}{{Esterases}}{{Enzymes}}{{Portal bar|Molecular and Cellular Biology|border=no}}2. ^{{cite journal | title = Exonuclease VII of Escherichia coli |author1 = Chase, J.W. |author2 =Richardson, C.C. |journal = J. Biol. Chem. |year = 1974 |volume = 249 |pages = 4553–4561 |pmid = 4602030 | issue = 14}} 3. ^{{cite journal | vauthors = Vales LD, Rabin BA, Chase JW | title = Subunit structure of Escherichia coli exonuclease VII | journal = J. Biol. Chem. | volume = 257 | issue = 15 | pages = 8799–805 |date=August 1982 | pmid = 6284744 | doi = | url = }} 2 : Protein families|EC 3.1.11 |
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