| 词条 | Exosortase |
| 释义 |
| Symbol = Exosortase_EpsH | Name = Transmembrane exosortase (Exosortase_EpsH) | image = | width = | caption = | Pfam= PF09721 | InterPro= | SMART= | Prosite = | SCOP = | TCDB = | OPM family= | OPM protein= | PDB= }} Exosortase refers to a family of integral membrane proteins that occur in Gram-negative bacteria and that recognize and cleave the carboxyl-terminal sorting signal PEP-CTERM.[1][2] The name derives from a predicted role analogous to sortase, despite the lack any detectable sequence homology, and a strong association of exosortase genes with exopolysaccharide or extracellular polymeric substance biosynthesis loci. Some archaea have an archaeosortase, related to exosortase rather than to sortases. Archaeosortase A recognizes the signal PGF-CTERM, found at the C-terminus of some archaeal S-layer proteins. Exosortase has not itself been characterized biochemically. However, recent site-directed mutagenesis work on archaeosortase A, an archaeal homolog of exosortases, strongly supports the notion of a Cys active site and convergent evolution with the sortases. [3] References1. ^{{cite journal | vauthors = Haft DH, Paulsen IT, Ward N, Selengut JD | title = Exopolysaccharide-associated protein sorting in environmental organisms: the PEP-CTERM/EpsH system. Application of a novel phylogenetic profiling heuristic | journal = BMC Biology | volume = 4 | pages = 29 | date = August 2006 | pmid = 16930487 | pmc = 1569441 | doi = 10.1186/1741-7007-4-29 }} {{membrane-protein-stub}}2. ^{{cite journal | vauthors = Haft DH, Payne SH, Selengut JD | title = Archaeosortases and exosortases are widely distributed systems linking membrane transit with posttranslational modification | journal = Journal of Bacteriology | volume = 194 | issue = 1 | pages = 36–48 | date = January 2012 | pmid = 22037399 | pmc = 3256604 | doi = 10.1128/JB.06026-11 | url = http://jb.asm.org/content/194/1/36.full }} 3. ^{{cite journal | vauthors = Abdul Halim MF, Rodriguez R, Stoltzfus JD, Duggin IG, Pohlschroder M | title = Conserved residues are critical for Haloferax volcanii archaeosortase catalytic activity: Implications for convergent evolution of the catalytic mechanisms of non-homologous sortases from archaea and bacteria | journal = Molecular Microbiology | volume = 108 | issue = 3 | pages = 276–287 | date = May 2018 | pmid = 29465796 | doi = 10.1111/mmi.13935 | url = }} 2 : Membrane proteins|Enzymes |
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