“Extracerebral decarboxylase inhibitor”的意思、由来-开放百科全书

词条

Extracerebral decarboxylase inhibitor

释义

References

{{Orphan|date=June 2013}}Extracerebral decarboxylase inhibitor is an inhibitory enzyme. It is used to inhibit the decarboxylation of L-DOPA to Dopamine outside the brain, i.e. in the blood. This is primarily co-administered with L-DOPA to combat Parkinsons Disease. Administration can prevent common side-effects, such as nausea and vomiting, as a result of interaction with D2 receptors in the vomiting center (or cheomoreceptor trigger zone) located outside the blood–brain barrier.^[1]

Examples of extracerebral decarboxylase inhibitors include Carbidopa and Benserazide.

References

1. ^{{Cite journal | doi = 10.1136/bmj.3.5777.729 | last1 = Calne | first1 = D. B. | last2 = Reid | first2 = J. L. | last3 = Vakil | first3 = S. D. | last4 = Rao | first4 = S. | last5 = Petrie | first5 = A. | last6 = Pallis | first6 = C. A. | last7 = Gawler | first7 = J. | last8 = Thomas | first8 = P. K. | last9 = Hilson | first9 = A. | title = Idiopathic Parkinsonism treated with an extracerebral decarboxylase inhibitor in combination with levodopa | journal = British Medical Journal | volume = 3 | issue = 5777 | pages = 729–732 | year = 1971 | pmid = 4938431 | pmc = 1798919}}

2 : Enzyme inhibitors|Parkinson's disease

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