| 词条 | Fallypride |
| 释义 |
| drug_name = Fallypride (18F) | image = Fallypride F18.svg | IUPAC_name = 5-(3-18F-fluoropropyl)-2,3-dimethoxy-N-[(2S)-1-prop-2-enylpyrrolidin-2-yl]methyl]benzamide | CAS_number = | PubChem= 10021692 | ChemSpiderID = 8197265 | ATC_prefix = none | smiles = COC1=CC(=CC(=C1OC)C(=O)NC[C@@H]2CCCN2CC=C)CCCF | C=20 | H=29 | F=1 | N=2 | O=3 | molecular_weight = 364.454263 g/mol | StdInChI = 1S/C20H29FN2O3/c1-4-10-23-11-6-8-16(23)14-22-20(24)17-12-15(7-5-9-21)13-18(25-2)19(17)26-3/h4,12-13,16H,1,5-11,14H2,2-3H3,(H,22,24)/t16-/m0/s1 | StdInChIKey = OABRYNHZQBZDMG-INIZCTEOSA-N | pregnancy_category = N/A | legal_status = Research compound }}Fallypride is a high affinity dopamine D2/D3 receptor antagonist used in medical research,[1] usually in the form of fallypride (18F) as a positron emission tomography (PET) radiotracer in human studies.[2][3] References1. ^{{Cite journal | pmid = 7627142| year = 1995| author1 = Mukherjee| first1 = J| title = Fluorinated benzamide neuroleptics--III. Development of (S)-N-(1-allyl-2-pyrrolidinyl)methyl-5-(3-18Ffluoropropyl)-2, 3-dimethoxybenzamide as an improved dopamine D-2 receptor tracer| journal = Nuclear Medicine and Biology| volume = 22| issue = 3| pages = 283–96| last2 = Yang| first2 = Z. Y.| last3 = Das| first3 = M. K.| last4 = Brown| first4 = T}} 2. ^{{Cite journal | pmid = 12325044| year = 2002| author1 = Mukherjee| first1 = J| title = Brain imaging of 18F-fallypride in normal volunteers: Blood analysis, distribution, test-retest studies, and preliminary assessment of sensitivity to aging effects on dopamine D-2/D-3 receptors| journal = Synapse| volume = 46| issue = 3| pages = 170–88| last2 = Christian| first2 = B. T.| last3 = Dunigan| first3 = K. A.| last4 = Shi| first4 = B| last5 = Narayanan| first5 = T. K.| last6 = Satter| first6 = M| last7 = Mantil| first7 = J| doi = 10.1002/syn.10128}} 3. ^{{Cite journal | pmid = 14627996| year = 2004| author1 = Rieck| first1 = R. W.| title = Distribution of dopamine D2-like receptors in the human thalamus: Autoradiographic and PET studies| journal = Neuropsychopharmacology| volume = 29| issue = 2| pages = 362–72| last2 = Ansari| first2 = M. S.| last3 = Whetsell Jr| first3 = W. O.| last4 = Deutch| first4 = A. Y.| last5 = Kessler| first5 = R. M.| doi = 10.1038/sj.npp.1300336}} External links
7 : Typical antipsychotics|Benzamides|Pyrrolidines|Phenol ethers|D2 antagonists|Radiopharmaceuticals|Allyl compounds |
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