| 词条 | Fcab |
| 释义 |
Fcabs are antibodies fragments engineered from the constant region of an antibody (Fc).[1] In naturally occurring antibodies (such as IgGs), the antigen-binding sites are located at the variable regions (Fab). OverviewFcabs can be expressed as soluble proteins or they can be engineered back into a full IgG. This type of antibodies are therefore able to recognise two different antigens, one at their Fab region and a second one at the Fc region, hence the name of bispecific antibodies. This antibody fragment is part of the modular antibody technology of F-star Biotechnology Ltd. References1. ^{{cite journal |vauthors=Wozniak-Knopp G, Bartl S, Bauer A, Mostageer M, Woisetschläger M, Antes B, Ettl K, Kainer M, Weberhofer G, Wiederkum S, Himmler G, Mudde GC, Rüker F | title=Introducing antigen-binding sites in structural loops of immunoglobulin constant domains: Fc fragments with engineered HER2/neu-binding sites and antibody properties. | journal=Protein Eng Des | year=2010 | volume=23 | issue=4 | pages=289–297 | pmid=20150180 | doi=10.1093/protein/gzq005}} See also
1 : Antibodies |
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