| 词条 | Fellutanine |
| 释义 |
Fellutanine A,[1] B,[1] C and D are bio-active diketopiperazine alkaloids isolated from the cultures of Penicillium fellutanum,[2] that belongs to a class of naturally occurring 2,5-diketopiperazines.[3] Originally they were thought to be based on the "trans" cyclic dipetide cyclo(L-Trp-D-Trp) [2] but were later shown to be based on the "cis" cyclic dipetide cyclo(L-Trp-L-Trp).[4] This was also confirmed when fellutanine A, B and C were isolated from Penicillium simplicissimum.[5] The fellutanines A−C, are non-annulated analogues of cyclo(L-Trp-L-Trp), but unlike their diannulated analogue fellutanine D are not cytotoxic. References1. ^1 {{cite journal |vauthors=Kozlovsky AG, Vinokurova NG, Adanin VM | title = Diketopiperazine alkaloids from the fungus Penicillium piscarium Westling | journal = Prikladnaia biokhimiia i mikrobiologiia | volume = 36 | issue = 3 | pages = 317–21| date= 2000 | pmid = 10867952 | url = }} {{organic-chem-stub}}2. ^1 {{cite journal |vauthors=Kozlovsky AG, Vinokurova NG, Adanin VM, Burkhardt G, Dahse HM, Gräfe U | title = New diketopiperazine alkaloids from Penicillium fellutanum | journal = Journal of Natural Products | volume = 63 | issue = 5 | pages = 698–700 | date=March 2000 | pmid = 10843594 | doi = 10.1021/np9903853 | url = }} 3. ^{{Cite journal | title = 2,5-Diketopiperazines: Synthesis, Reactions, Medicinal Chemistry, and Bioactive Natural Products | author = Borthwick AD | journal = Chemical Reviews | year = 2012 | volume = 112 | issue = 7 | pages = 3641–3716 | doi = 10.1021/cr200398y | pmid = 22575049}} 4. ^{{cite journal |vauthors=Kozlovsky AG, Vinokurova NG, Adanin VM, Burkhardt G, Dahse HM, Gräfe U | title = New diketopiperazine alkaloids from Penicillium fellutanum | journal = Journal of Natural Products | volume = 64 | issue = 4 | pages = 553–554| date= 2001 | doi = 10.1021/np010005p | url = }} 5. ^{{cite book|title= Studies in Natural Products Chemistry|date = December 2005|publisher=Elsevier |doi=10.1016/S1572-5995(05)80064-X| volume = 32 | pages=549–609|author= Hayashi H |chapter=Bioactive alkaloids of fungal origin}} 3 : Diketopiperazines|Indole alkaloids|Penicillium |
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