词条 | Finrozole |
释义 |
| ImageFile = Finrozole.svg | ImageSize = 230 | ImageAlt = | IUPACName = 4-[(1R,2S)-3-(4-Fluorophenyl)-2-hydroxy-1-(1,2,4-triazol-1-yl)propyl]benzonitrile | OtherNames = | Section1 = {{Chembox Identifiers | CASNo = 160146-17-8 | PubChem = 6918277 | ChemSpiderID = 5293483 | ChEMBL = 2218882 | InChI = 1S/C18H15FN4O/c19-16-7-3-13(4-8-16)9-17(24)18(23-12-21-11-22-23)15-5-1-14(10-20)2-6-15/h1-8,11-12,17-18,24H,9H2/t17-,18+/m0/s1 | InChIKey = SLJZVZKQYSKYNV-ZWKOTPCHSA-N | SMILES = C1=CC(=CC=C1C[C@@H]([C@@H](C2=CC=C(C=C2)C#N)N3C=NC=N3)O)F | Section2 = {{Chembox Properties | C=18 | H=15 | F=1 | N=4 | O=1 | Appearance = | Density = | MeltingPt = | BoilingPt = | Solubility = | Section3 = {{Chembox Hazards | MainHazards = | FlashPt = | AutoignitionPt = }}Finrozole is an aromatase (CYP19A1) inhibitor.[1] References1. ^{{cite journal|pmid=23402939|year=2013|last1=Huuskonen|first1=P|last2=Myllynen|first2=P|last3=Storvik|first3=M|last4=Pasanen|first4=M|title=The effects of aflatoxin B1 on transporters and steroid metabolizing enzymes in JEG-3 cells|volume=218|issue=3|pages=200–6|doi=10.1016/j.toxlet.2013.01.015|journal=Toxicology Letters}} {{Estrogenics}}{{organic-compound-stub}}{{pharma-stub}} 4 : Aromatase inhibitors|Nitriles|Triazoles|Fluoroarenes |
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