| 词条 | FKBP7 | |||||||||||||||||||||||||||||||||||||||||||||||||
| 释义 |
Model organismsModel organisms have been used in the study of FKBP7 function. A conditional knockout mouse line, called Fkbp7tm2a(KOMP)Wtsi[3][4] was generated as part of the International Knockout Mouse Consortium program — a high-throughput mutagenesis project to generate and distribute animal models of disease to interested scientists — at the Wellcome Trust Sanger Institute.[5][6][7]Male and female animals underwent a standardized phenotypic screen to determine the effects of deletion.[10][8]
Twenty three tests were carried out on mutant mice, but no significant abnormalities were observed.[11] References1. ^1 2 {{cite web | title = FK506 binding protein 7| url = https://www.ncbi.nlm.nih.gov/gene/51661| accessdate = 2011-12-06}} 2. ^{{Cite journal | last1 = Nakamura | first1 = T. | last2 = Yabe | first2 = D. | last3 = Kanazawa | first3 = N. | last4 = Tashiro | first4 = K. | last5 = Sasayama | first5 = S. | last6 = Honjo | first6 = T. | doi = 10.1006/geno.1998.5571 | title = Molecular Cloning, Characterization, and Chromosomal Localization of FKBP23, a Novel FK506-Binding Protein with Ca2+-Binding Ability | journal = Genomics | volume = 54 | issue = 1 | pages = 89–98 | year = 1998 | pmid = 9806833 | pmc = }} 3. ^{{cite web |url=http://www.knockoutmouse.org/martsearch/search?query=Fkbp7 |title=International Knockout Mouse Consortium}} 4. ^{{cite web |url=http://www.informatics.jax.org/searchtool/Search.do?query=MGI:4364239 |title=Mouse Genome Informatics}} 5. ^{{Cite journal| last1 = Skarnes |first1 =W. C.| doi = 10.1038/nature10163 | last2 = Rosen | first2 = B.| last3 = West | first3 = A. P.| last4 = Koutsourakis | first4 = M.| last5 = Bushell | first5 = W.| last6 = Iyer | first6 = V.| last7 = Mujica | first7 = A. O.| last8 = Thomas | first8 = M.| last9 = Harrow | first9 = J.| last10 = Cox | first10 = T.| last11 = Jackson | first11 = D.| last12 = Severin | first12 = J.| last13 = Biggs | first13 = P.| last14 = Fu | first14 = J.| last15 = Nefedov | first15 = M.| last16 = De Jong | first16 = P. J.| last17 = Stewart | first17 = A. F.| last18 = Bradley | first18 = A. | title = A conditional knockout resource for the genome-wide study of mouse gene function | journal = Nature | volume = 474 | issue = 7351 | pages = 337–342 | year = 2011 | pmid = 21677750 | pmc =3572410 }} 6. ^{{cite journal |author=Dolgin E |title=Mouse library set to be knockout |journal=Nature |volume=474 |issue=7351 |pages=262–3 |date=June 2011 |pmid=21677718 |doi=10.1038/474262a }} 7. ^{{cite journal |vauthors=Collins FS, Rossant J, Wurst W |title=A mouse for all reasons |journal=Cell |volume=128 |issue=1 |pages=9–13 |date=January 2007 |pmid=17218247 |doi=10.1016/j.cell.2006.12.018 }} 8. ^{{cite journal|vauthors=van der Weyden L, White JK, Adams DJ, Logan DW | title=The mouse genetics toolkit: revealing function and mechanism. | journal=Genome Biol | year= 2011 | volume= 12 | issue= 6 | pages= 224 | pmid=21722353 | doi=10.1186/gb-2011-12-6-224 | pmc=3218837}} 9. ^{{cite web |url=http://www.sanger.ac.uk/mouseportal/phenotyping/MBYW/salmonella-challenge/ |title=Salmonella infection data for Fkbp7 |publisher=Wellcome Trust Sanger Institute}} 10. ^{{cite web |url=http://www.sanger.ac.uk/mouseportal/phenotyping/MBYW/citrobacter-challenge/ |title=Citrobacter infection data for Fkbp7 |publisher=Wellcome Trust Sanger Institute}} 11. ^1 2 {{cite journal| doi = 10.1111/j.1755-3768.2010.4142.x| title = The Sanger Mouse Genetics Programme: High throughput characterisation of knockout mice| year = 2010| author = Gerdin AK| journal = Acta Ophthalmologica| volume = 88| issue = S248 }} 12. ^Mouse Resources Portal, Wellcome Trust Sanger Institute. Further reading
| last1 = Patterson | first1 = C. E. | last2 = Gao | first2 = J. | last3 = Rooney | first3 = A. P. | last4 = Davis | first4 = E. C. | title = Genomic Organization of Mouse and Human 65 kDa FK506-Binding Protein Genes and Evolution of the FKBP Multigene Family | doi = 10.1006/geno.2002.6777 | journal = Genomics | volume = 79 | issue = 6 | pages = 881–889 | year = 2002 | pmid = 12036304 | pmc = }}
| last1 = Matsuda | first1 = M. | last2 = Koide | first2 = T. | last3 = Yorihuzi | first3 = T. | last4 = Hosokawa | first4 = N. | last5 = Nagata | first5 = K. | title = Molecular Cloning of a Novel Ubiquitin-like Protein, UBIN, That Binds to ER Targeting Signal Sequences | doi = 10.1006/bbrc.2000.4149 | journal = Biochemical and Biophysical Research Communications | volume = 280 | issue = 2 | pages = 535–540 | year = 2001 | pmid = 11162551 | pmc = }}{{refend}}{{gene-2-stub}} 3 : Human proteins|Genes mutated in mice|EF-hand-containing proteins |
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