| 词条 | Fluroxene |
| 释义 |
| IUPAC_name = (2,2,2-trifluoroethoxy)ethene | image = Fluroxene.svg | CAS_number = 406-90-6 | ATC_prefix = None | ATC_suffix = | PubChem = 9844 | DrugBank = | ChemSpiderID = 9461 | chemical_formula = | C=4 | H=5 | F=3 | O=1 | molecular_weight = 126.077 g/mol | SMILES = C=COCC(F)(F)F | StdInChI = 1S/C4H5F3O/c1-2-8-3-4(5,6)7/h2H,1,3H2 | StdInChIKey = DLEGDLSLRSOURQ-UHFFFAOYSA-N | bioavailability = | protein_bound = | metabolism = | elimination_half-life = | excretion = | pregnancy_AU = | pregnancy_US = | pregnancy_category= | legal_AU = | legal_CA = | legal_UK = | legal_US = | legal_status = | routes_of_administration = }}Fluroxene (INN, USAN; brand name Fluoromar), or 2,2,2-trifluoroethyl vinyl ether, is a volatile, inhalational anesthetic, and was the first halogenated hydrocarbon anesthetic to be introduced.[1][2] It was synthesized in 1951, and was introduced for clinical use in 1954, but was voluntarily withdrawn from the market in 1974 due to its potential flammability and accumulating evidence that it could cause organ toxicity.[2][1][3] In any case, prior to being discontinued, it had largely been superseded by halothane.[4] Fluroxene is metabolized to 2,2,2-trifluoroethanol, a compound responsible for some of the toxicity seen with fluroxene use.[5][6] See also
References1. ^1 {{cite book|author1=Robert K. Stoelting|author2=Simon C. Hillier|title=Pharmacology and Physiology in Anesthetic Practice|url=https://books.google.com/books?id=lHhGtkvOoM0C&pg=PT142|date=11 January 2012|publisher=Lippincott Williams & Wilkins|isbn=978-1-4511-6583-8|pages=142–}} {{General anesthetics}}{{GABAAR PAMs}}{{nervous-system-drug-stub}}2. ^1 {{cite book|author1=Paul G Barash|author2=Bruce F Cullen|author3=Robert K Stoelting |author4=Michael Cahalan |author5=M Christine Stock|title=Clinical Anesthesia|url=https://books.google.com/books?id=vGtSChnRRJ8C&pg=PT113|date=1 January 2011|publisher=Lippincott Williams & Wilkins|isbn=978-1-4511-2297-8|pages=113–}} 3. ^{{cite book|author1=Monte Lichtiger|author2=Frank Moya|title=Introduction to the practice of anesthesia|url=https://books.google.com/books?id=ecZpAAAAMAAJ|date=1 January 1978|publisher=Medical Dept., Harper & Row|isbn=978-0-06-141534-0}} 4. ^{{cite book|title=Acta anaesthesiologica Belgica|url=https://books.google.com/books?id=KmsxAAAAIAAJ|year=1974|publisher=Acta Medica Belgica.}} 5. ^{{Cite journal| author = V. Fiserova-Bergerova | title = Metabolism and toxicity of 2,2,2-trifluoroethyl vinyl ether | journal = Environmental Health Perspectives | volume = 21 | pages = 225–230 | year = 1977| pmid = 25763| pmc = 1475355 }} 6. ^{{Cite journal | author = L. S. Kaminsky & J. M. Fraser | title = Multiple aspects of the toxicity of fluroxene and its metabolite 2,2,2-trifluoroethanol | journal = Critical reviews in toxicology | volume = 19 | issue = 2 | pages = 87–112 | year = 1988| doi = 10.3109/10408448809014901 | pmid = 2906849}} 6 : General anesthetics|Ethers|Organofluorides|GABAA receptor positive allosteric modulators|Trifluoromethyl compounds|Vinyl compounds |
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