| 词条 | FMR1-AS1 gene |
| 释义 |
In molecular biology, FMR1 antisense RNA 1 (FMR1-AS1), also known as ASFMR1 or FMR4, is a long non-coding RNA. The FMR1-AS1 gene overlaps, and is antisense to, the CGG repeat region of the FMR1 gene.[1] Its expression is upregulated in fragile X syndrome premutation carriers, and silenced in patients with fragile X syndrome.[1][2] FMR1-AS1 has an anti-apoptotic function.[2] See also
References1. ^1 {{cite journal|vauthors=Ladd PD, Smith LE, Rabaia NA, Moore JM, Georges SA, Hansen RS | title=An antisense transcript spanning the CGG repeat region of FMR1 is upregulated in premutation carriers but silenced in full mutation individuals. | journal=Hum Mol Genet | year= 2007 | volume= 16 | issue= 24 | pages= 3174–87 | pmid=17921506 | doi=10.1093/hmg/ddm293 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=17921506 |display-authors=etal}} {{PDB Gallery|geneid=100126270}}2. ^1 {{cite journal|vauthors=Khalil AM, Faghihi MA, Modarresi F, Brothers SP, Wahlestedt C | title=A novel RNA transcript with antiapoptotic function is silenced in fragile X syndrome. | journal=PLoS ONE | year= 2008 | volume= 3 | issue= 1 | pages= e1486 | pmid=18213394 | doi=10.1371/journal.pone.0001486 | pmc=2194623 | url= }} {{open access}} 1 : Non-coding RNA |
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