| 词条 | Forkhead-associated domain |
| 释义 |
| Symbol = FHA | Name = FHA domain | image = PDB 2csw EBI.jpg | width = | caption = solution structure of the fha domain of human ubiquitin ligase protein rnf8 | Pfam = PF00498 | Pfam_clan = CL0357 | InterPro = IPR000253 | SMART = | PROSITE = PDOC50006 | MEROPS = | SCOP = 1qu5 | TCDB = | OPM family = | OPM protein = | CAZy = | CDD = }} In molecular biology, the forkhead-associated domain (FHA domain) is a phosphopeptide recognition domain found in many regulatory proteins.[1] It displays specificity for phosphothreonine-containing epitopes but will also recognise phosphotyrosine with relatively high affinity. It spans approximately 80-100 amino acid residues folded into an 11-stranded beta sandwich, which sometimes contains small helical insertions between the loops connecting the strands.[2] To date, genes encoding FHA-containing proteins have been identified in eubacterial and eukaryotic but not archaeal genomes. The domain is present in a diverse range of proteins, such as kinases, phosphatases, kinesins, transcription factors, RNA-binding proteins and metabolic enzymes which partake in many different cellular processes - DNA repair, signal transduction, vesicular transport and protein degradation are just a few examples. References1. ^{{cite journal | vauthors = Hofmann K, Bucher P | title = The FHA domain: a putative nuclear signalling domain found in protein kinases and transcription factors | journal = Trends in Biochemical Sciences | volume = 20 | issue = 9 | pages = 347–9 | date = September 1995 | pmid = 7482699 | doi = 10.1016/S0968-0004(00)89072-6 }} 2. ^{{cite journal | vauthors = Durocher D, Jackson SP | title = The FHA domain | journal = FEBS Letters | volume = 513 | issue = 1 | pages = 58–66 | date = February 2002 | pmid = 11911881 | doi = 10.1016/S0014-5793(01)03294-X }} External links
1 : Protein families |
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