| 词条 | Formetorex |
| 释义 |
| ImageFile = N-formylamphetamine.png | ImageSize = 200px | ImageAlt = An image of formetamide | IUPACName = N-(1-Phenylpropan-2-yl)formamide | OtherNames = Formetorex N-Formylamphetamine N-(alpha-Methylphenethyl)formamide |Section1={{Chembox Identifiers | CASNo = | ChEMBL = 1395071 | PubChem = 65614 | SMILES = CC(CC1=CC=CC=C1)NC=O | ChemSpiderID = 59055 | InChI = 1S/C10H13NO/c1-9(11-8-12)7-10-5-3-2-4-6-10/h2-6,8-9H,7H2,1H3,(H,11,12) }} |Section2={{Chembox Properties | C=10 | H=13 | N=1 | O=1 | Appearance = | Density = | MeltingPt = | BoilingPt = | Solubility = }} |Section3={{Chembox Hazards | MainHazards = | FlashPt = | AutoignitionPt = }} }}Formetorex (INN), also known as formetamide or N-formylamphetamine, is a substituted amphetamine described as an anorectic which does not appear to have ever been marketed.[1] Formetorex is also an intermediate in the production of amphetamine by the "Leuckart reaction."[2] It is also commonly found as an impurity in clandestine labs where this synthesis method is used.[2][3] Due to the simplicity of the Leuckart reaction, it is the most popular synthetic route employed for the illicit manufacture of amphetamines.[2] The synthesis involves a non-metal reduction that is typically carried out in three steps.[2] For amphetamine synthesis, a mixture of phenylacetone and formamide (sometimes in the presence of formic acid) or ammonium formate, is heated until a condensation reaction results in the intermediate product, formetamide.[2] In the second step, formetamide is hydrolysed using hydrochloric acid, and the reaction mixture is then basified, isolated, and steam distilled to produce the free base.[2] The final step, the product is dissolved in an organic solvent and precipitated as the sulphate salt of amphetamine by adding sulfuric acid.[2] {{Annotated image 4|image = Amphetamine - Leuckart reaction.png |image-width=600 |width=600 |height=100 |align=center |caption=Amphetamine synthesis via the Leuckart reaction |alt=Diagram of amphetamine synthesis via the Leuckart reaction |icon=none |annotations= }} References1. ^{{cite book|author1=C.R. Ganellin|author2=David J. Triggle|title=Dictionary of Pharmacological Agents|url=https://books.google.com/books?id=Z_mfTTIApVEC&pg=PA568|date=21 November 1996|publisher=CRC Press|isbn=978-0-412-46630-4|pages=568–}} 2. ^1 2 3 4 5 6 {{cite book | url = http://www.unodc.org/pdf/scientific/stnar34.pdf | title = Recommended methods of the identification and analysis of amphetamine, methamphetamine, and their ring-substituted analogues in seized materials | accessdate = 14 October 2013 |year = 2006 | author = Laboratory and Scientific Section | publisher = United Nations Office on Drugs and Crime Vienna |location = New York | isbn = 92-1-148208-9}} 3. ^{{cite journal|last=Kram|first=TC|title=Reidentification of a major impurity in illicit amphetamine.|journal=Journal of Forensic Sciences|date=July 1979|volume=24|issue=3|pages=596–9|pmid=541629}} External links
6 : Substituted amphetamines|Amphetamine|Anorectics|Norepinephrine-dopamine releasing agents|Stimulants|Formamides |
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