Fortune is both a surname and a given name. Notable people with the name include:

• Amos Fortune (citizen of Jaffrey) (c. 1710–1801), African American ex-slave and businessman
• Dion Fortune (1890–1946), born Violet Mary Firth, British occultist and author
• Jesse Fortune (1930–2009), American Chicago blues singer
• J.D. Fortune (1973), American singer and song writer who fronted the band INXS from September 2005 till August 2011
• Jimmy Fortune (born 1955), American country music singer
• Jimmy Fortune (born 1972), Irish jockey
• John Fortune (1939-2013), British comedian best known for his work on the TV series Bremner, Bird and Fortune
• Marc-Antoine Fortuné (born 1981), French Guianese football player
• Quinton Fortune (born 1977), South African football player
• Robert Fortune (1812–1880), Scottish botanist and traveller best known for introducing tea plants from China to India
• Rose Fortune (1774–1864), African American businessperson and first female police officer in Canada
• Scott Fortune (born 1966), American former volleyball player
• Seán Fortune (1954-1999), Irish priest and alleged child molester
• Sonny Fortune (1939–2018), American jazz musician
• Steven Fortune, computer scientist, the namesake of Fortune's algorithm for the convex hull problem
• Timothy Thomas Fortune (1856–1928), American orator, civil rights leader, journalist, writer, editor and publisher
• Victor Fortune (1883–1949), British Army major general

• Fortune (circa 1743–1798), African-American slave
• Fortune FitzRoy, Duchess of Grafton (1920- ) British Mistress of the Robes
• Fortune Gallo (1878–1970), opera impresario
• Fortune Gordien (1922–1990), American athlete, primarily in the discus throw
• Fortuné Méaulle (1844–1901), French engraver

• Amos Fortune (comics), DC Comics supervillain
• Anna Fortune, DC Comics character
• Dominic Fortune, Marvel Comics character
• Reginald Fortune, fictional detective of H. C. Bailey
• Fortune, character from Metal Gear Solid 2: Sons of Liberty
• Miss Fortune, the Bounty Hunter, a playable champion character in the action real-time strategy video game League of Legends

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