Frank Mayo may refer to:

• Frank M. Mayo (1839–1896), American actor and comedian
• Frank Mayo (actor) (1889–1963), American silent screen actor
• Frank R. Mayo (1908–1987), SRI chemist who won the 1967 ACS Award in Polymer Chemistry for Mayo–Lewis equation

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• Polan, Toledo
• Pol Antràs
• Polany (disambiguation)
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• Polanyi (disambiguation)
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• Polanyi (surname)
• Polany-Kolonia
• Polany, Lesser Poland Voivodeship
• Polany, Lublin Voivodeship
• Polany, Masovian Voivodeship
• Polany, Podkarpackie Voivodeship
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• Polanówka, Lublin County
• Polanówka, Opole Lubelskie County
• Polanówka, Tomaszów Lubelski County
• Polanów, Świętokrzyskie Voivodeship
• Pola Oloixarac
• Polapare River