| 词条 | Frank Uhlmann |
| 释义 |
| name = | birth_name = | image = Frank Uhlmann FRS.jpg | image_size = | alt = | caption = Frank Uhlmann in 2015, portrait via the Royal Society | birth_date = | birth_place = | other_names = | residence = | citizenship = | nationality = | fields = {{Plainlist|
| workplaces = {{Plainlist|
| patrons = | alma_mater = University of Tübingen (PhD) | thesis_title = Reconstitution and characterisation of human replication factor C | thesis_url = https://www.worldcat.org/oclc/51443586 | thesis_year = 1997 | doctoral_advisor = | academic_advisors = | doctoral_students = | notable_students = | known_for = | influences = | influenced = | awards = {{Plainlist|
| website = {{URL|crick.ac.uk/research/a-z-researchers/researchers-t-u/frank-uhlmann}} | footnotes = | spouse = | children = }}Frank Uhlmann FRS[4] is a group leader at the Francis Crick Institute in London.[5][6][7][8][9][10][11] EducationUhlmann was educated at the University of Tübingen where he was awarded a PhD in 1997.[1][12] During his PhD, he worked with Jerard Hurwitz at the Memorial Sloan Kettering Cancer Center in New York City.[13][14][15] CareerFollowing his PhD, Uhlmann moved to the Research Institute of Molecular Pathology in Vienna for postdoctoral research with Kim Nasmyth. In 2000, he established a laboratory at the Imperial Cancer Research Fund (now Cancer Research UK)[16] in London, which ultimately became part of the Francis Crick Institute.[15] Awards and honoursUhlmann was elected a Fellow of the Royal Society (FRS) in 2015. His certificate of election reads: {{centred pull quote|Frank Uhlmann's discovery with Nasmyth of 'separase', the protease that cleaves the cohesive links between sister chromatids to trigger anaphase is a key contribution to our understanding of the cell cycle. He has made major contributions to our understanding of the mechanisms of sister chromatid cohesion, and their relationship to cell cycle regulation. He generated the first chromosome-wide high resolution maps of proteins involved in chromosome packaging and segregation. He showed that yeast cohesins accumulate at sites of converging transcription distinct from the sites where their loading factors bind, apparently reflecting interaction with the transcription apparatus; and that cohesin loading factors are recruited to specific chromosomal sites through interaction with the nucleosome remodelling complex Rsc. He has identified genes required for cohesion establishment, and shown that one of these, EcoI, acetylates cohesin during DNA replication, thereby locking it onto DNA and his studies of the link between cohesion regulation and the cell cycle have shown that as well as cleaving cohesin, separase promotes mitotic exit by activating the Cdc14 phosphatase in a protease-independent manner.[4]}} In 2006, Uhlmann was also elected a member of the European Molecular Biology Organization (EMBO)[17] and awarded the EMBO Gold Medal.[2][3] References1. ^1 {{cite web|archiveurl=https://web.archive.org/web/20150524191533/http://www.crick.ac.uk/research/a-z-researchers/researchers-t-u/frank-uhlmann|archivedate=2015-05-24|url=http://www.crick.ac.uk/research/a-z-researchers/researchers-t-u/frank-uhlmann|title=Frank Uhlmann: Mechanism and control of chromosome segregation|publisher=The Crick Institute}} {{Francis Crick Institute}}{{FRS 2015}}{{Authority control}}{{DEFAULTSORT:Uhlmann, Frank}}2. ^1 {{cite web|archiveurl=https://web.archive.org/web/20150414000617/http://www.embo.org/news/press-releases/press-releases-2006/frank-uhlmann-of-london-research-institute-wins-embo-gold|archivedate=2015-04-14|url=http://www.embo.org/news/press-releases/press-releases-2006/frank-uhlmann-of-london-research-institute-wins-embo-gold|title=Frank Uhlmann of London Research Institute wins 'EMBO Gold'|publisher=EMBO}} 3. ^1 {{Cite journal | last1 = Uhlmann | first1 = F. | title = What is your assay for sister-chromatid cohesion? | doi = 10.1038/sj.emboj.7601898 | journal = The EMBO Journal | volume = 26 | issue = 22 | pages = 4609–4618 | year = 2007 | pmid = 17962808| pmc =2080813 }} 4. ^1 2 {{cite web |url=https://royalsociety.org/people/fellowship/2015/frank-uhlmann/|title = Dr Frank Uhlmann FRS: Group Leader, The Francis Crick Institute |publisher=The Royal Society |archivedate=2015-05-02 |archiveurl=https://web.archive.org/web/20150502204138/https://royalsociety.org/people/fellowship/2015/frank-uhlmann/ |location=London}} 5. ^{{Scopus|id=7005894260}} 6. ^{{Cite journal | pmid = 10403247| year = 1999| author1 = Uhlmann| first1 = F| title = Sister-chromatid separation at anaphase onset is promoted by cleavage of the cohesin subunit Scc1| journal = Nature| volume = 400| issue = 6739| pages = 37–42| last2 = Lottspeich| first2 = F| last3 = Nasmyth| first3 = K| doi = 10.1038/21831}} 7. ^{{Cite journal | pmid = 11081625| year = 2000| author1 = Uhlmann| first1 = F | authorlink1 = Frank Uhlmann| title = Cleavage of cohesin by the CD clan protease separin triggers anaphase in yeast| journal = Cell| volume = 103| issue = 3| pages = 375–86| last2 = Wernic| first2 = D| last3 = Poupart| first3 = M. A.| last4 = Koonin| first4 = E. V. | authorlink4 = Eugene Koonin| last5 = Nasmyth| first5 = K | authorlink5 = Kim Nasmyth | doi=10.1016/s0092-8674(00)00130-6}} 8. ^{{Cite journal | pmid = 9990856| pmc = 316435| year = 1999| author1 = Tóth| first1 = A| title = Yeast cohesin complex requires a conserved protein, Eco1p(Ctf7), to establish cohesion between sister chromatids during DNA replication| journal = Genes & Development| volume = 13| issue = 3| pages = 320–33| last2 = Ciosk| first2 = R| last3 = Uhlmann| first3 = F | authorlink3 = Frank Uhlmann| last4 = Galova| first4 = M| last5 = Schleiffer| first5 = A| last6 = Nasmyth| first6 = K | authorlink6 = Kim Nasmyth | doi=10.1101/gad.13.3.320}} 9. ^{{Cite journal | pmid = 10827941| year = 2000| author1 = Nasmyth| first1 = K | authorlink1 = Kim Nasmyth| title = Splitting the chromosome: Cutting the ties that bind sister chromatids| journal = Science | location = New York, N.Y.| volume = 288| issue = 5470| pages = 1379–85| last2 = Peters| first2 = J. M.| last3 = Uhlmann| first3 = F | authorlink3 = Frank Uhlmann | doi=10.1126/science.288.5470.1379}} 10. ^{{Cite journal | pmid = 25569132| pmc = 4287440| year = 2015| author1 = Godfrey| first1 = M| title = Nur1 dephosphorylation confers positive feedback to mitotic exit phosphatase activation in budding yeast| journal = PLOS Genetics| volume = 11| issue = 1| pages = e1004907| last2 = Kuilman| first2 = T| last3 = Uhlmann| first3 = F | authorlink3 = Frank Uhlmann| doi = 10.1371/journal.pgen.1004907}} {{open access}} 11. ^{{Cite journal | pmid = 25922992| pmc = 4413874| year = 2015| author1 = Cheng| first1 = T. M.| title = A simple biophysical model emulates budding yeast chromosome condensation| journal = eLife| volume = 4| last2 = Heeger| first2 = S| last3 = Chaleil| first3 = R. A.| last4 = Matthews| first4 = N| last5 = Stewart| first5 = A| last6 = Wright| first6 = J| last7 = Lim| first7 = C| last8 = Bates| first8 = P. A.| last9 = Uhlmann| first9 = F | authorlink9 = Frank Uhlmann| doi = 10.7554/eLife.05565}} {{open access}} 12. ^{{cite thesis |degree=PhD |first=Frank|last=Uhlmann |title=Reconstitution and characterization of human replication factor C |publisher=University of Tübingen |year=1997 |url=http://search.proquest.com/docview/304393027/|oclc=51443586}} 13. ^{{Cite journal | pmid = 9092550| doi = 10.1074/jbc.272.15.10065| year = 1997| author1 = Uhlmann| first1 = F| title = Identification of regions within the four small subunits of human replication factor C required for complex formation and DNA replication| journal = The Journal of Biological Chemistry| volume = 272| issue = 15| pages = 10065–71| last2 = Gibbs| first2 = E| last3 = Cai| first3 = J| last4 = O'Donnell| first4 = M| last5 = Hurwitz| first5 = J}} 14. ^{{Cite journal | pmid = 8692848| pmc = 39056| year = 1996| author1 = Uhlmann| first1 = F| title = In vitro reconstitution of human replication factor C from its five subunits| journal = Proceedings of the National Academy of Sciences of the United States of America| volume = 93| issue = 13| pages = 6521–6| last2 = Cai| first2 = J| last3 = Flores-Rozas| first3 = H| last4 = Dean| first4 = F. B.| last5 = Finkelstein| first5 = J| last6 = O'Donnell| first6 = M| last7 = Hurwitz| first7 = J | doi=10.1073/pnas.93.13.6521}} 15. ^1 {{cite web|archiveurl=https://web.archive.org/web/20150525162435/http://www.crick.ac.uk/research/a-z-researchers/researchers-t-u/frank-uhlmann/biography/|archivedate=2015-05-25|url=http://www.crick.ac.uk/research/a-z-researchers/researchers-t-u/frank-uhlmann/biography/|title=Frank Uhlmann biography|publisher=Francis Crick Institute|location=London}} 16. ^{{cite web|archiveurl=https://web.archive.org/web/20150527084945/http://pcc.ecmcnetwork.org.uk/cancer-info/cancerandresearch/ourcurrentresearch/researchbygrantee/dr-frank-uhlmann|archivedate=2015-05-27|url=http://pcc.ecmcnetwork.org.uk/cancer-info/cancerandresearch/ourcurrentresearch/researchbygrantee/dr-frank-uhlmann|title=Frank Uhlmann: Understanding how cells divide|publisher=Cancer Research UK}} 17. ^1 {{cite web|url=http://www.embo.org/documents/members/The_EMBO_Pocket_Directory.pd|title=The EMBO Pocket Directory|archiveurl=https://web.archive.org/web/20150316002020/http://www.embo.org/documents/members/The_EMBO_Pocket_Directory.pdf|archivedate=2015-03-16|publisher=European Molecular Biology Organization}} 4 : Living people|Members of the European Molecular Biology Organization|Fellows of the Royal Society|Year of birth missing (living people) |
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