| 词条 | Frataxin-like domain |
| 释义 |
| Symbol = Frataxin_Cyay | Name = Frataxin-like domain | image = PDB 1ekg EBI.jpg | width = | caption = mature human frataxin | Pfam = PF01491 | Pfam_clan = | InterPro = IPR002908 | SMART = | PROSITE = | MEROPS = | SCOP = 1dlx | TCDB = 9.B.21 | OPM family = | OPM protein = | CAZy = | CDD = cd00503 }} In molecular biology, the frataxin-like domain is a protein domain found in proteins including eukaryotic frataxin and bacterial CyaY. The bacterial CyaY proteins are iron-sulphur cluster (FeS) metabolism proteins which are homologous to eukaryotic frataxin. Partial phylogenetic profiling suggests that CyaY most likely functions as part of the ISC system for FeS cluster biosynthesis, and is supported by experimental data in some species.[1][2][3] References1. ^{{cite journal |vauthors=Haft DH, Paulsen IT, Ward N, Selengut JD | title = Exopolysaccharide-associated protein sorting in environmental organisms: the PEP-CTERM/EpsH system. Application of a novel phylogenetic profiling heuristic | journal = BMC Biol. | volume = 4 | issue = | pages = 29 | year = 2006 | pmid = 16930487 | pmc = 1569441 | doi = 10.1186/1741-7007-4-29 | url = }} {{InterPro content|IPR002908}}2. ^{{cite journal |vauthors=Layer G, Ollagnier-de Choudens S, Sanakis Y, Fontecave M | title = Iron-sulfur cluster biosynthesis: characterization of Escherichia coli CYaY as an iron donor for the assembly of [2Fe-2S] clusters in the scaffold IscU | journal = J. Biol. Chem. | volume = 281 | issue = 24 | pages = 16256–63 |date=June 2006 | pmid = 16603772 | doi = 10.1074/jbc.M513569200 | url = }} 3. ^{{cite journal |vauthors=Vivas E, Skovran E, Downs DM | title = Salmonella enterica strains lacking the frataxin homolog CyaY show defects in Fe-S cluster metabolism in vivo | journal = J. Bacteriol. | volume = 188 | issue = 3 | pages = 1175–9 |date=February 2006 | pmid = 16428423 | pmc = 1347345 | doi = 10.1128/JB.188.3.1175-1179.2006 | url = }} 1 : Protein domains |
| 随便看 |
|
开放百科全书收录14589846条英语、德语、日语等多语种百科知识，基本涵盖了大多数领域的百科知识，是一部内容自由、开放的电子版国际百科全书。