词条 | Reference ranges for blood tests | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
释义 |
Reference ranges for blood tests are sets of values used by a health professional to interpret a set of medical test results from blood samples. Reference ranges for blood tests are studied within the field of clinical chemistry (also known as "clinical biochemistry", "chemical pathology" or "pure blood chemistry"), the area of pathology that is generally concerned with analysis of bodily fluids. Blood test results should always be interpreted using the reference range provided by the laboratory that performed the test.[1] InterpretationA reference range is usually defined as the set of values 95 percent of the normal population falls within (that is, 95% prediction interval).[2] It is determined by collecting data from vast numbers of laboratory tests. Plasma or whole bloodIn this article, all values (except the ones listed below) denote blood plasma concentration, which is approximately 60–100% larger than the actual blood concentration if the amount inside red blood cells (RBCs) is negligible. The precise factor depends on hematocrit as well as amount inside RBCs. Exceptions are mainly those values that denote total blood concentration, and in this article they are:
A few values are for inside red blood cells only:
Units
Arterial or venousIf not otherwise specified, a reference range for a blood test is generally the venous range, as the standard process of obtaining a sample is by venipuncture. An exception is for acid-base and blood gases, which are generally given for arterial blood. Still, the blood values are approximately equal between the arterial and venous sides for most substances, with the exception of acid-base, blood gases and drugs (used in therapeutic drug monitoring (TDM) assays).[4] Arterial levels for drugs are generally higher than venous levels because of extraction while passing through tissues.[4] Usual or optimalReference ranges are usually given as what are the usual (or normal) values found in the population, more specifically the prediction interval that 95% of the population fall into. This may also be called standard range. In contrast, optimal (health) range or therapeutic target is a reference range or limit that is based on concentrations or levels that are associated with optimal health or minimal risk of related complications and diseases. For most substances presented, the optimal levels are the ones normally found in the population as well. More specifically, optimal levels are generally close to a central tendency of the values found in the population. However, usual and optimal levels may differ substantially, most notably among vitamins and blood lipids, so these tables give limits on both standard and optimal (or target) ranges. In addition, some values, including troponin I and brain natriuretic peptide, are given as the estimated appropriate cutoffs to distinguish healthy people from people with specific conditions, which here are myocardial infarction and congestive heart failure, respectively, for the aforementioned substances. Variability{{Further information|Reference range}}References range may vary with age, sex, race, pregnancy,[5] diet, use of prescribed or herbal drugs and stress. Reference ranges often depend on the analytical method used, for reasons such as inaccuracy, lack of standardisation, lack of certified reference material and differing antibody reactivity.[6] Also, reference ranges may be inaccurate when the reference groups used to establish the ranges are small. Sorted by concentrationBy unitsUnits don't necessarily imply anything about molarity or mass. A few substances are below this main interval, e.g. thyroid stimulating hormone, being measured in mU/L, or above, like rheumatoid factor and CA19-9, being measured in U/mL. By enzyme activityWhite blood cellsSorted by categoryIons and trace metals{{Further information|Trace metal|Metals in medicine}}Included here are also related binding proteins, like ferritin and transferrin for iron, and ceruloplasmin for copper.
Acid-base and blood gases{{Further information|Acid-base homeostasis}}{{further information|Arterial blood gas}}If arterial/venous is not specified for an acid-base or blood gas value, then it generally refers to arterial, and not venous which otherwise is standard for other blood tests. Acid-base and blood gases are among the few blood constituents that exhibit substantial difference between arterial and venous values.[4] Still, pH, bicarbonate and base excess show a high level of inter-method reliability between arterial and venous tests, so arterial and venous values are roughly equivalent for these.[34]
Liver function{{Further information|Liver function tests}}
Cardiac tests
Lipids{{Further information|Blood lipids}}
Tumour markers{{Further information|Tumour markers}}
EndocrinologyThyroid hormones{{Further information|Thyroid function tests}}
Sex hormones{{Further information|Sex steroid}}The diagrams below take inter-cycle and inter-woman variability into account in displaying reference ranges for estradiol, progesterone, FSH and LH.
Other hormones{{Further information|Hormones}}
VitaminsAlso including the vitamin B12)-related amino acid homocysteine.
Toxins
HematologyRed blood cellsThese values (except Hemoglobin in plasma) are for total blood and not only blood plasma. White blood cellsThese values are for total blood and not only blood plasma.
Coagulation
ImmunologyAcute phase proteinsAcute phase proteins are markers of inflammation.
Isotypes of antibodies{{Further information|Antibody}}
Autoantibodies{{For|clinical associations|Autoantibody}}Autoantibodies are usually absent or very low, so instead of being given in standard reference ranges, the values usually denote where they are said to be present, or whether the test is a positive test. There may also be an equivocal interval, where it is uncertain whether there is a significantly increased level. All included values[160] are given for the ELISA test.
Other immunology
Other enzymes and proteins
Other electrolytes and metabolitesElectrolytes and metabolites: For iron and copper, some related proteins are also included.
Medication
See also
Notes1. ^{{cite web|title=Reference Ranges and What They Mean|url=http://labtestsonline.org/understanding/features/ref-ranges/start/6|publisher=Lab Tests Online (USA)|accessdate=22 June 2013}} 2. ^[https://books.google.com/books?id=Je_pJfb2r0cC&pg=PA19 Page 19] in: {{cite book |author=Stephen K. Bangert MA MB BChir MSc MBA FRCPath; William J. Marshall MA MSc MBBS FRCP FRCPath FRCPEdin FIBiol; Marshall, William Leonard |title=Clinical biochemistry: metabolic and clinical aspects |publisher=Churchill Livingstone/Elsevier |location=Philadelphia |year=2008 |pages= |isbn=978-0-443-10186-1 |oclc= |doi= |accessdate=}} 3. ^[https://books.google.com/books?id=BfdighlyGiwC&printsec=frontcover&hl=en Page 34: Units of measurement] in Medical toxicologyBy Richard C. DartEdition: 3, illustratedPublished by Lippincott Williams & Wilkins, 2004{{ISBN|0-7817-2845-2}}, {{ISBN|978-0-7817-2845-4}}1914 pages 4. ^1 2 Arterial versus venous reference ranges - Brief Article Medical Laboratory Observer, April, 2000 by D. Robert Dufour 5. ^{{Cite journal | doi = 10.1097/AOG.0b013e3181c2bde8| pmid = 19935037| title = Pregnancy and Laboratory Studies| journal = Obstetrics & Gynecology| volume = 114| issue = 6| pages = 1326–31| year = 2009| last1 = Abbassi-Ghanavati | first1 = M. | last2 = Greer | first2 = L. G. | last3 = Cunningham | first3 = F. G. }} 6. ^{{cite journal|last=Armbruster|first=David|author2=Miller |title=The Joint Committee for Traceability in Laboratory Medicine (JCTLM): A Global Approach to Promote the Standardisation of Clinical Laboratory Test Results|journal=The Clinical Biochemist Reviews|date=August 2007|volume=28|issue=3|pages=105–14|accessdate=|pmc=1994110|pmid=17909615}} 7. ^[https://www.uniprot.org/uniprot/P01189 PROOPIOMELANOCORTIN; NCBI --> POMC] Retrieved on September 28, 2009 8. ^1 2 3 Derived from molar values using molar mass of 22.99 g•mol−1 9. ^1 Derived from molar values using molar mass of 39.10 g•mol−1 10. ^1 Derived from molar values using molar mass of 35.45 g•mol−1 11. ^1 {{cite journal |vauthors=Larsson L, Ohman S |title=Serum ionized calcium and corrected total calcium in borderline hyperparathyroidism |journal=Clin. Chem. |volume=24 |issue=11 |pages=1962–65 |date=November 1978 |pmid=709830 |doi= |url=http://www.clinchem.org/cgi/pmidlookup?view=long&pmid=709830}} 12. ^1 2 3 Derived from molar values using molar mass of 40.08 g•mol−1 13. ^1 2 Derived from mass values using molar mass of 40.08 g•mol−1 14. ^1 2 3 4 5 6 7 8 9 10 11 {{cite web |author=Slon S |title=Serum Iron |url=http://uimc.discoveryhospital.com/main.php?t=enc&id=1456 |date=2006-09-22 |publisher=University of Illinois Medical Center |accessdate=2006-07-06 |deadurl=yes |archiveurl=https://web.archive.org/web/20061028111833/http://uimc.discoveryhospital.com/main.php?t=enc&id=1456 |archivedate=2006-10-28 |df= }} 15. ^1 2 3 Diagnostic Chemicals Limited > Serum Iron-SL Assay {{webarchive|url=https://web.archive.org/web/20090106161044/http://www.dclmexico.com/ingles/hierro_sl.pdf |date=2009-01-06 }} July 15, 2005 16. ^1 2 3 4 5 6 7 8 9 10 11 12 Derived from mass values using molar mass of 55.85 g•mol−1 17. ^1 Table 1. Page 133" Clinical Chemistry 45, No. 1, 1999 (stating 1.9–3.3 g/L) 18. ^1 Derived by dividing mass values with molar mass 19. ^1 2 3 [https://www.nlm.nih.gov/medlineplus/ency/article/003490.htm Ferritin] by: Mark Levin, MD, Hematologist and Oncologist, Newark, NJ. Review provided by VeriMed Healthcare Network 20. ^1 {{cite web|url=http://emedicine.medscape.com/article/177216-workup#c8|title=Hemochromatosis Workup|author=Andrea Duchini|website=Medscape|accessdate=2016-07-14}} Updated: Jan 02, 2016 21. ^1 2 3 4 Derived from mass values using molar mass of 450,000 g•mol−1 22. ^1 {{cite journal |vauthors=Mitchell ML, Filippone MD, Wozniak TF |title=Metastatic carcinomatous cirrhosis and hepatic hemosiderosis in a patient heterozygous for the H63D genotype |journal=Arch. Pathol. Lab. Med. |volume=125 |issue=8 |pages=1084–7 |date=August 2001 |pmid=11473464 |doi= 10.1043/0003-9985(2001)125<1084:MCCAHH>2.0.CO;2|url=http://journals.allenpress.com/jrnlserv/?request=get-abstract&issn=0003-9985&volume=125&page=1084 |doi-broken-date=2019-01-31 }} 23. ^1 {{cite journal |vauthors=Diaz J, Tornel PL, Martinez P |title=Reference intervals for blood ammonia in healthy subjects, determined by microdiffusion |journal=Clin. Chem. |volume=41 |issue=7 |page=1048 |date=July 1995 |pmid=7600690 |doi= |url=}} 24. ^1 2 3 Derived from molar values using molar mass of 17.03 g/mol 25. ^1 Derived from mass values using molar mass of 63.55 g•mol−1 26. ^{{Cite GPnotebook|1040580630|Reference range for copper}} 27. ^1 Derived from mass using molar mass of 151kDa 28. ^{{cite book |author=Walter F. Boron |title=Medical Physiology: A Cellular And Molecular Approaoch |publisher=Elsevier/Saunders |location= |year= 2005|pages= |isbn=978-1-4160-2328-9 |oclc= |doi=}} Page 849 29. ^1 {{cite web |url=http://www.dlolab.com/PDFs/DLO-OCTOBER-2008-LAB-UPDATE.pdf |title=Archived copy |accessdate=2010-01-17 |deadurl=yes |archiveurl=https://web.archive.org/web/20100307231954/http://www.dlolab.com/PDFs/DLO-OCTOBER-2008-LAB-UPDATE.pdf |archivedate=2010-03-07 |df= }} 30. ^1 Derived from molar values using molar mass of 65.38 g/mol 31. ^1 Derived from mass values using molar mass of 65.38 g/mol 32. ^1 Derived from molar values using molar mass of 24.31 g/mol 33. ^1 Derived from mass values using molar mass of 24.31 g/mol 34. ^{{cite journal |vauthors=Middleton P, Kelly AM, Brown J, Robertson M |title=Agreements between arterial and central venous values for pH, bicarbonate, base excess, and lactate |journal=Emerg Med J |volume=23 |issue=8 |pages=622–24 |date=August 2006 |pmid=16858095 |pmc=2564165 |doi=10.1136/emj.2006.035915 |url=}} 35. ^1 2 3 4 5 6 7 8 9 10 11 The Medical Education Division of the Brookside Associates--> ABG (Arterial Blood Gas) Retrieved on Dec 6, 2009 36. ^1 Derived from molar values using molar mass of 1.01 g•mol−1 37. ^1 2 3 4 5 6 7 8 9 10 11 12 MERCK MANUALS > Common Medical Tests > Blood Tests Last full review/revision February 2003 38. ^1 2 3 4 5 6 7 Derived from mmHg values using 0.133322 kPa/mmHg 39. ^1 Derived from molar values using molar mass of 44.010 g/mol 40. ^1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 Blood Test Results – Normal Ranges {{Webarchive|url=https://web.archive.org/web/20121102092931/http://www.bloodbook.com/ranges.html |date=2012-11-02 }} Bloodbook.Com 41. ^1 2 3 Derived from molar values using molar mass of 61 g/mol 42. ^{{Cite GPnotebook|288686147|Reference range (albumin)}} 43. ^1 Derived from mass using molecular weight of 65kD 44. ^1 2 3 4 Derived from mass values using molar mass of 585g/mol 45. ^1 Derived from molar values using molar mass of 585g/mol 46. ^1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99 100 101 102 103 104 105 106 107 Last page of {{cite book |author1=Deepak A. Rao |author2=Le, Tao |author3=Bhushan, Vikas |title=First Aid for the USMLE Step 1 2008 (First Aid for the Usmle Step 1) |publisher=McGraw-Hill Medical |location= |year=2007 |pages= |isbn=978-0-07-149868-5 |oclc= |doi= |accessdate=}} 47. ^1 2 3 GPnotebook > reference range (AST) Retrieved on Dec 7, 2009 48. ^1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 Fachwörterbuch Kompakt Medizin E-D/D-E. Author: Fritz-Jürgen Nöhring. Edition 2. Publisher:Elsevier, Urban&FischerVerlag, 2004. {{ISBN|3-437-15120-7}}, {{ISBN|978-3-437-15120-0}}. Length: 1288 pages 49. ^1 {{cite web|url=http://www.mdi-labor.de/l_leistungsverzeichnis_detail.php?u_id=663&init=letter |title=Gamma-GT |work=Leistungsverzeichnis |publisher=Medizinisch-Diagnostische Institute |accessdate=20 November 2011 |deadurl=yes |archiveurl=https://web.archive.org/web/20120425233448/http://www.mdi-labor.de/l_leistungsverzeichnis_detail.php?u_id=663&init=letter |archivedate=25 April 2012 |df= }} 50. ^1 {{Cite GPnotebook|1436155929|Creatine kinase}} 51. ^1 2 3 [https://books.google.com/books?id=AUSIRcV_as0C&pg=PA585 Page 585] in: {{cite book |author=Lee, Mary Ann |title=Basic Skills in Interpreting Laboratory Data |publisher=Amer Soc of Health System |location= |year=2009 |pages= |isbn=978-1-58528-180-0 |oclc= |doi= |accessdate=}} 52. ^1 2 3 Muscle Information and Courses from MediaLab, Inc. > Cardiac Biomarkers Retrieved on April 22, 2010 53. ^{{cite web|url=http://emedicine.medscape.com/article/2073935-overview|title=Troponins|author=Ashvarya Mangla|website=medscape|accessdate=2017-07-24}} Updated: Jan 14, 2015 54. ^1 2 {{cite journal |vauthors=Brenden CK, Hollander JE, Guss D, etal |title=Gray zone BNP levels in heart failure patients in the emergency department: results from the Rapid Emergency Department Heart Failure Outpatient Trial (REDHOT) multicenter study |journal=American Heart Journal |volume=151 |issue=5 |pages=1006–11 |date=May 2006 |pmid=16644322 |doi=10.1016/j.ahj.2005.10.017}} 55. ^1 2 {{cite journal |vauthors=Strunk A, Bhalla V, Clopton P, etal |title=Impact of the history of congestive heart failure on the utility of B-type natriuretic peptide in the emergency diagnosis of heart failure: results from the Breathing Not Properly Multinational Study |journal=The American Journal of Medicine |volume=119 |issue=1 |pages=69.e1–11 |date=January 2006 |pmid=16431187 |doi=10.1016/j.amjmed.2005.04.029}} 56. ^1 [https://books.google.com/books?id=AUSIRcV_as0C&pg=PA220 Page 220] in: {{cite book |author=Lee, Mary Ann |title=Basic Skills in Interpreting Laboratory Data |publisher=Amer Soc of Health System |location= |year=2009 |pages= |isbn=978-1-58528-180-0 |oclc= |doi= |accessdate=}} 57. ^1 2 3 4 5 Derived from values in mg/dl to mmol/l, by dividing by 89, according to faqs.org: What are mg/dl and mmol/l? How to convert? Glucose? Cholesterol? Last Update July 21, 2009. Retrieved on July 21, 2009 58. ^1 2 3 Derived from values in mg/dl to mmol/l, using molar mass of 386.65 g/mol 59. ^1 2 {{Cite GPnotebook|-214630397|Reference range (cholesterol)}} 60. ^1 2 3 4 5 6 7 Royal College of Pathologists of Australasia; Cholesterol (HDL and LDL) – plasma or serum Last Updated: Monday, 6 August 2007 61. ^What Your Cholesterol Levels Mean. American Heart Association. Retrieved on September 12, 2009 62. ^1 2 3 4 5 6 7 8 9 Derived from values in mmol/l, using molar mass of 386.65 g/mol 63. ^[https://web.archive.org/web/20010903133121/http://www.labtestsonline.org/understanding/analytes/hdl/test.html American Association for Clinical Chemistry; HDL Cholesterol] 64. ^GP Notebook > range (reference, ca-125) Retrieved on Jan 5, 2009 65. ^ClinLab Navigator > Test Interpretations > CA-125 Retrieved on March 8, 2011 66. ^1 {{cite journal |vauthors=Bjerner J, Høgetveit A, Wold Akselberg K, etal |title=Reference intervals for carcinoembryonic antigen (CEA), CA125, MUC1, Alfa-foeto-protein (AFP), neuron-specific enolase (NSE) and CA19.9 from the NORIP study |journal=Scandinavian Journal of Clinical and Laboratory Investigation |volume= 68|issue= 8|pages=703–13 |date=June 2008 |pmid=18609108 |doi=10.1080/00365510802126836 |url=}} 67. ^Carcinoembryonic Antigen(CEA) at MedicineNet 68. ^1 2 {{cite journal|last1=Luboldt|first1=Hans-Joachim|last2=Schindler|first2=Joachim F.|last3=Rübben|first3=Herbert|title=Age-Specific Reference Ranges for Prostate-Specific Antigen as a Marker for Prostate Cancer|journal=EAU-EBU Update Series|volume=5|issue=1|year=2007|pages=38–48|issn=18712592|doi=10.1016/j.eeus.2006.10.003}} 69. ^1 2 {{cite journal |vauthors=Basuyau JP, Mallet E, Leroy M, Brunelle P |title=Reference intervals for serum calcitonin in men, women, and children |journal=Clinical Chemistry |volume=50 |issue=10 |pages=1828–30 |date=October 2004 |pmid=15388660 |doi=10.1373/clinchem.2003.026963}} 70. ^The TSH Reference Range Wars: What's "Normal?", Who is Wrong, Who is Right... By Mary Shomon, About.com. Updated: June 19, 2006. About.com Health's Disease and Condition 71. ^1 2006 Press releases: Thyroid Imbalance? Target Your Numbers {{webarchive|url=https://web.archive.org/web/20080303175142/http://www.aace.com/newsroom/press/2006/index.php?r=20060110 |date=2008-03-03 }} Contacts: Bryan Campbell American] Association of Clinical Endocrinologists 72. ^1 The TSH Reference Range Wars: What's "Normal?", Who is Wrong, Who is Right... By Mary Shomon, About.com. Updated: June 19, 2006 73. ^1 {{cite web| last =Demers| first =Laurence M.| authorlink =|author2=Carole A. Spencer | title = LMPG: Laboratory Support for the Diagnosis and Monitoring of Thyroid Disease| website =| publisher =National Academy of Clinical Biochemistry (USA)| year =2002| url =http://www.nacb.org/lmpg/thyroid_LMPG_PDF.stm | doi =| accessdate =2007-04-13 }} – see Section 2. Pre-analytic factors 74. ^1 2 3 4 5 Free T4; Thyroxine, Free; T4, Free {{webarchive|url=https://web.archive.org/web/20101222231732/http://labs.unchealthcare.org/labstestinfo/f_tests/free_t4.htm |date=2010-12-22 }} UNC Health Care System 75. ^Derived from molar values using molar mass of 776.87 g/mol 76. ^1 2 3 {{cite journal |vauthors=van der Watt G, Haarburger D, Berman P |title=Euthyroid patient with elevated serum free thyroxine |journal=Clinical Chemistry |volume=54 |issue=7 |pages=1239–41 |date=July 2008 |pmid=18593963 |doi=10.1373/clinchem.2007.101428}} 77. ^1 2 3 4 5 Derived from mass values using molar mass of 776.87 g/mol 78. ^1 2 3 Derived from mass values using molar mass of 650.98 g/mol 79. ^1 {{cite journal |id={{INIST|13391788}} |vauthors=Cioffi M, Gazzerro P, Vietri MT, etal |title=Serum concentration of free T3, free T4 and TSH in healthy children |journal=Journal of Pediatric Endocrinology & Metabolism |volume=14 |issue=9 |pages=1635–9 |year=2001 |pmid=11795654 |doi=10.1515/jpem.2001.14.9.1635}} 80. ^1 2 3 4 5 6 7 8 9 10 11 12 13 14 Table 4: Typical reference ranges for serum assays {{webarchive|url=https://web.archive.org/web/20110701163827/http://www.thyroidmanager.org/chapter6/Ch-6b-2.htm |date=2011-07-01 }} – Thyroid Disease Manager 81. ^{{cite journal|last1=Häggström|first1=Mikael|title=Reference ranges for estradiol, progesterone, luteinizing hormone and follicle-stimulating hormone during the menstrual cycle|journal=WikiJournal of Medicine|date=2014|volume=1|issue=1|doi=10.15347/wjm/2014.001}} 82. ^1 Life Extension Foundation > Blood Testing Protocols 83. ^1 Andrology Australia: Your Health > Low Testosterone > Diagnosis 84. ^1 2 3 Derived from mass values using molar mass of 288.42g/mol 85. ^1 2 3 4 5 6 Derived from molar values using molar mass of 288.42g/mol 86. ^1 2 3 [https://www.nlm.nih.gov/medlineplus/ency/article/003707.htm#Normal%20Values MedlinePlus > Testosterone] Update Date: 3/18/2008. Updated by: Elizabeth H. Holt, MD, PhD, Yale University. Review provided by VeriMed Healthcare Network. Also reviewed by David Zieve, MD, MHA, Medical Director 87. ^1 2 3 Derived from mass values using molar mass of 330.46g/mol 88. ^1 2 3 4 5 6 7 8 9 reference range (FSH) GPnotebook. Retrieved on September 27, 2009 89. ^1 2 3 4 5 Values taken from day 1 after LH surge in: {{cite journal |vauthors=Stricker R, Eberhart R, Chevailler MC, Quinn FA, Bischof P, Stricker R |title=Establishment of detailed reference values for luteinizing hormone, follicle stimulating hormone, estradiol, and progesterone during different phases of the menstrual cycle on the Abbott ARCHITECT analyzer |journal=Clinical Chemistry and Laboratory Medicine |volume=44 |issue=7 |pages=883–87 |year=2006 |pmid=16776638 |doi=10.1515/CCLM.2006.160}} 90. ^1 2 3 4 5 New York Hospital Queens > Services and Facilities > Patient Testing > Pathology > New York Hospital Queens Diagnostic Laboratories > Test Directory > Reference Ranges{{dead link|date=April 2018 |bot=InternetArchiveBot |fix-attempted=yes }} Retrieved on Nov 8, 2009 91. ^1 Mayo Medical Laboratories > Test ID: LH, Luteinizing Hormone (LH), Serum {{Webarchive|url=https://web.archive.org/web/20160925112456/http://www.mayomedicallaboratories.com/test-catalog/Clinical+and+Interpretive/8663 |date=2016-09-25 }}, retrieved December 2012 92. ^1 2 3 4 5 6 GPNotebook – reference range (oestradiol) Retrieved on September 27, 2009 93. ^1 2 3 4 5 6 Derived from molar values using molar mass of 272.38g/mol 94. ^1 2 3 Total amount multiplied by 0.022 according to 2.2% presented in: {{cite journal |vauthors=Wu CH, Motohashi T, Abdel-Rahman HA, Flickinger GL, Mikhail G |title=Free and protein-bound plasma estradiol-17 beta during the menstrual cycle |journal=J. Clin. Endocrinol. Metab. |volume=43 |issue=2 |pages=436–45 |date=August 1976 |pmid=950372 |doi= 10.1210/jcem-43-2-436|url=}} 95. ^1 Derived from mass values using molar mass of 314.46 g/mol 96. ^1 Bhattacharya Sudhindra Mohan (July/August 2005) Mid-luteal phase plasma progesterone levels in spontaneous and clomiphene citrate induced conception cycles J Obstet Gynecol India Vol. 55, No. 4 : July/August 2005 Pg 350-352 97. ^1 Dehydroepiandrosterone Sulfate (DHEA-S), Serum {{Webarchive|url=https://web.archive.org/web/20180314080932/https://www.mayomedicallaboratories.com/test-catalog/Clinical+and+Interpretive/8493 |date=2018-03-14 }} at Mayo Foundation For Medical Education And Research. Retrieved July 2012 98. ^1 2 3 Unit Code 91215 {{webarchive|url=https://web.archive.org/web/20110720111631/http://www.mayomedicallaboratories.com/test-catalog/print.php?unit_code=91215 |date=2011-07-20 }} at Mayo Clinic Medical Laboratories. Retrieved April 2011 99. ^1 Antimullerian Hormone (AMH), Serum from Mayo Medical Laboratories. Retrieved April 2012. 100. ^1 Derived from mass values using 140,000 g/mol, as given in* {{cite journal |vauthors=Hampl R, Šnajderová M, Mardešić T |title=Antimüllerian hormone (AMH) not only a marker for prediction of ovarian reserve |journal=Physiological Research |volume=60 |issue=2 |pages=217–23 |year=2011 |pmid=21114374 |url=http://www.biomed.cas.cz/physiolres/pdf/60/60_217.pdf}} 101. ^1 Derived from mass values using molar mass of 4540g/mol. This molar mass was taken from: [https://www.uniprot.org/uniprot/P01189 PROOPIOMELANOCORTIN; NCBI --> POMC] Retrieved on September 28, 2009 102. ^{{cite web|url=http://children.webmd.com/adrenocorticotropic-hormone?page=2|title=Adrenocorticotropic Hormone:Normal|date=09-03-2006|publisher=WebMD|accessdate=2008-11-09}} 103. ^Derived from molar values using molar mass of 4540g/mol. This molar mass was taken from: [https://www.uniprot.org/uniprot/P01189 PROOPIOMELANOCORTIN; NCBI --> POMC] Retrieved on September 28, 2009 104. ^1 2 3 Biochemistry Reference Ranges at Good Hope Hospital Retrieved on Nov 8, 2009 105. ^1 2 3 Derived from molar values using molar mass of 362 g/mol 106. ^1 2 3 4 5 6 7 {{cite journal |vauthors=Friedrich N, Alte D, Völzke H, etal |title=Reference ranges of serum IGF-1 and IGFBP-3 levels in a general adult population: results of the Study of Health in Pomerania (SHIP) |journal=Growth Hormone & IGF Research |volume=18 |issue=3 |pages=228–37 |date=June 2008 |pmid=17997337 |doi=10.1016/j.ghir.2007.09.005}} 107. ^1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 Taken from the assay method giving the lowest and highest estimate, respectively, from Table 2 in: {{cite journal |vauthors=Beltran L, Fahie-Wilson MN, McKenna TJ, Kavanagh L, Smith TP |title=Serum total prolactin and monomeric prolactin reference intervals determined by precipitation with polyethylene glycol: evaluation and validation on common immunoassay platforms |journal=Clinical Chemistry |volume=54 |issue=10 |pages=1673–81 |date=October 2008 |pmid=18719199 |doi=10.1373/clinchem.2008.105312}} 108. ^1 Derived from molar values using molar mass of 9.4 kDa 109. ^1 [https://www.ncbi.nlm.nih.gov/pmc/articles/mid/NIHMS10653/table/T2/ Table 2] in: {{cite journal |vauthors=Aloia JF, Feuerman M, Yeh JK |title=Reference range for serum parathyroid hormone |journal=Endocr Pract |volume=12 |issue=2 |pages=137–44 |year=2006 |pmid=16690460 |pmc=1482827 |doi= 10.4158/ep.12.2.137|url=}} 110. ^1 Derived from mass values using molar mass of 9.4 kDa 111. ^1 2 3 4 5 Derived from molar values using molar mass 400.6 g/mol 112. ^1 2 3 {{cite book |author=Bender, David A. |chapter=Vitamin D |title=Nutritional biochemistry of the vitamins |publisher=Cambridge University Press |location=Cambridge |year=2003 |pages= |isbn=978-0-521-80388-5 |chapter-url=https://books.google.com/books?id=pxEJNs0IUo4C}} Retrieved December 10, 2008 through Google Book Search. 113. ^1 2 3 {{cite journal |vauthors=Bischoff-Ferrari HA, Dietrich T, Orav EJ, etal |title=Higher 25-hydroxyvitamin D concentrations are associated with better lower-extremity function in both active and inactive persons aged > or =60 y |journal=The American Journal of Clinical Nutrition |volume=80 |issue=3 |pages=752–58 |date=September 2004 |pmid=15321818 |url=http://www.ajcn.org/cgi/pmidlookup?view=long&pmid=15321818 |doi=10.1093/ajcn/80.3.752}} 114. ^1 2 3 {{cite journal |vauthors=Reusch J, Ackermann H, Badenhoop K |title=Cyclic changes of vitamin D and PTH are primarily regulated by solar radiation: 5-year analysis of a German (50 degrees N) population |journal=Horm. Metab. Res. |volume=41 |issue=5 |pages=402–07 |date=May 2009 |pmid=19241329 |doi=10.1055/s-0028-1128131 |url=}} 115. ^1 2 3 4 5 6 7 {{cite journal |vauthors=Vasquez A, Cannell J |title=Calcium and vitamin D in preventing fractures: data are not sufficient to show inefficacy |journal=BMJ |volume=331 |issue=7508 |pages=108–09; author reply 109 |date=July 2005 |pmid=16002891 |pmc=558659 |doi=10.1136/bmj.331.7508.108-b}} 116. ^1 2 3 4 5 6 7 8 9 10 11 12 13 Adëeva Nutritionals Canada > Optimal blood test values {{webarchive|url=https://web.archive.org/web/20090529032656/http://adeeva.com/resources/bloodtestscomplete.html |date=2009-05-29 }} Retrieved on July 9, 2009 117. ^1 Converted from values in mcU/mL by dividing with a factor of 11.2 mcU/mL per ng/(mL*hour), as given in* New Assays for Aldosterone, Renin and Parathyroid Hormone {{webarchive|url=https://web.archive.org/web/20111027045833/http://depts.washington.edu/labweb/referencelab/print/endo.pdf |date=2011-10-27 }} University ofWashington, Department of Laboratory Medicine. Retrieved Mars 2011 118. ^1 {{cite journal |vauthors=Pratt RE, Flynn JA, Hobart PM, Paul M, Dzau VJ |title=Different secretory pathways of renin from mouse cells transfected with the human renin gene |journal=The Journal of Biological Chemistry |volume=263 |issue=7 |pages=3137–41 |date=March 1988 |pmid=2893797 |url=http://www.jbc.org/cgi/pmidlookup?view=long&pmid=2893797}} 119. ^1 2 3 New Assays for Aldosterone, Renin and Parathyroid Hormone {{webarchive|url=https://web.archive.org/web/20111027045833/http://depts.washington.edu/labweb/referencelab/print/endo.pdf |date=2011-10-27 }} University of Washington, Department of Laboratory Medicine. Retrieved Mars 2011 120. ^1 Converted from values in ng/(mL*hour) by multiplying with a factor of 11.2 mcU/mL per ng/(mL*hour), as given in* New Assays for Aldosterone, Renin and Parathyroid Hormone {{webarchive|url=https://web.archive.org/web/20111027045833/http://depts.washington.edu/labweb/referencelab/print/endo.pdf |date=2011-10-27 }} University ofWashington, Department of Laboratory Medicine. Retrieved Mars 2011 121. ^1 Converted from mass values using molar mass of 360.44 g/mol 122. ^1 2 3 {{cite journal |vauthors=Tiu SC, Choi CH, Shek CC, etal |title=The use of aldosterone-renin ratio as a diagnostic test for primary hyperaldosteronism and its test characteristics under different conditions of blood sampling |journal=The Journal of Clinical Endocrinology and Metabolism |volume=90 |issue=1 |pages=72–78 |date=January 2005 |pmid=15483077 |doi=10.1210/jc.2004-1149|citeseerx=10.1.1.117.5182 }} 123. ^1 2 3 4 5 Central Manchester University Hospitals --> Reference ranges Retrieved on July 9, 2009 124. ^University of Kentucky Chandler Medical Center > Clinical Lab Reference Range Guide Retrieved on April 28, 2009 125. ^1 2 3 4 Derived from mass values using molar mass of 441 mol−1 126. ^1 GPnotebook > B12 Retrieved on April 28, 2009 127. ^1 Derived form molar values using molar mass of 1355g/mol 128. ^1 Derived from mass values using molar mass of 1355g/mol 129. ^1 2 3 The Doctor's Doctor: Homocysteine 130. ^1 2 3 Derived from molar values using molar massof 135 g/mol 131. ^1 Derived from mass values using molar mass of 176 grams per mol 132. ^1 2 For Driving under the influence by country, see Drunk driving law by country 133. ^Derived from mass values using molar mass of 46g/mol 134. ^1 2 3 4 Derived from mass values using 64,500 g/mol. This molar mass was taken from: {{cite journal |vauthors=Van Beekvelt MC, Colier WN, Wevers RA, Van Engelen BG |title=Performance of near-infrared spectroscopy in measuring local O2 consumption and blood flow in skeletal muscle |journal=J Appl Physiol |volume=90 |issue=2 |pages=511–19 |year=2001 |pmid=11160049|doi=10.1152/jappl.2001.90.2.511 }} 135. ^1 2 3 Normal Lab Values {{webarchive|url=https://web.archive.org/web/20141216130827/http://musom.marshall.edu/usmle/usmlelabvalues.htm |date=2014-12-16 }} at Marshall University Joan C. Edwards School of Medicine. Retrieved July 2013 136. ^1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99 100 101 102 103 104 105 106 107 108 109 110 111 112 113 114 115 116 117 118 119 120 121 122 123 124 125 126 Reference range list from Uppsala University Hospital ("Laborationslista"). Artnr 40284 Sj74a. Issued on April 22, 2008 137. ^1 2 3 4 5 6 7 molar concentration as given for hemoglobin above, but multiplied by 4, according to: {{cite journal |vauthors=Lodemann P, Schorer G, Frey BM |title=Wrong molar hemoglobin reference values-a longstanding error that should be corrected |journal=Annals of Hematology |volume=89 |issue=2 |pages=209 |date=February 2010 |pmid=19609525 |doi=10.1007/s00277-009-0791-x}} 138. ^1 2 3 Derived from mass concentration, using molar mass of 64,458 g/mol. This molar mass was taken from: {{cite journal |vauthors=Van Beekvelt MC, Colier WN, Wevers RA, Van Engelen BG |title=Performance of near-infrared spectroscopy in measuring local O2 consumption and blood flow in skeletal muscle |journal=J Appl Physiol |volume=90 |issue=2 |pages=511–519 |year=2001 |pmid=11160049|doi=10.1152/jappl.2001.90.2.511 }}. Subsequently, 1 g/dL = 0.1551 mmol/L 139. ^1 2 3 4 5 6 7 lymphomation.org > Tests & Imaging > Labs > Complete Blood Count Retrieved on May 14, 2009 140. ^1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 [https://books.google.com/books?id=3PJVLH1NmQAC Clinical Laboratory Medicine. By Kenneth D. McClatchey. Page 807.] 141. ^Determination of monocyte count by hematological analyzers, manual method and flow cytometry in polish population Central European Journal of Immunology 1-2/2006. (Centr Eur J Immunol 2006; 31 (1-2): 1-5) authors: Elżbieta Górska, Urszula Demkow, Roman Pińkowski, Barbara Jakubczak, Dorota Matuszewicz, Jolanta Gawęda, Wioletta Rzeszotarska, Maria Wąsik, 142. ^1 2 3 4 gpnotebook.co.uk > blood constituents (reference range) Retrieved on May 14, 2009 143. ^1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99 100 101 102 103 104 105 Normal Reference Range Table {{webarchive|url=https://web.archive.org/web/20111225185659/http://pathcuric1.swmed.edu/pathdemo/nrrt.htm |date=2011-12-25 }} from The University of Texas Southwestern Medical Center at Dallas. Used in Interactive Case Study Companion to Pathologic basis of disease. 144. ^1 {{cite journal |vauthors=Demirin H, Ozhan H, Ucgun T, Celer A, Bulur S, Cil H, Gunes C, Yildirim HA |title=Normal range of mean platelet volume in healthy subjects: Insight from a large epidemiologic study |journal=Thromb. Res. |volume=128 |issue=4 |pages=358–60 |year=2011 |pmid=21620440 |doi=10.1016/j.thromres.2011.05.007 |url=}} 145. ^1 Normal Values: RBC, Hgb, Hct, Indices, RDW, Platelets, and MPV (Conventional Units) {{Webarchive|url=https://web.archive.org/web/20110727010934/http://www.labcareplus.org/docs/REFERENCE_RANGES.pdf |date=2011-07-27 }} From labcareplus. Retrieved 4 nov, 2010 146. ^1 {{cite journal |vauthors=Lozano M, Narváez J, Faúndez A, Mazzara R, Cid J, Jou JM, Marín JL, Ordinas A |title=[Platelet count and mean platelet volume in the Spanish population] |language=Spanish|journal=Med Clin (Barc) |volume=110 |issue=20 |pages=774–77 |year=1998 |pmid=9666418 |doi= |url=}} 147. ^1 {{MedlinePlusEncyclopedia|003652}} 148. ^1 {{EMedicine|article|2084978|Antithrombin III}} 149. ^1 Antithrombin CO000300 in Coagulation Test Handbook at Massachusetts General Hospital. In turn citing* Elizabeth M. Van Cott, M.D., and Michael Laposata, M.D., Ph.D., "Coagulation." In: Jacobs DS et al, ed. The Laboratory Test Handbook, 5th Edition. Lexi-Comp, Cleveland, 2001; 327-358. 150. ^1 Retrieved on November 20, 2009 151. ^{{cite journal |vauthors=Böttiger LE, Svedberg CA |title=Normal erythrocyte sedimentation rate and age |journal=Br Med J |volume=2 |issue=5544 |pages=85–87 |year=1967 |pmid=6020854 |doi= 10.1136/bmj.2.5544.85|pmc=1841240}} 152. ^1 {{cite journal |vauthors=Miller A, Green M, Robinson D |title=Simple rule for calculating normal erythrocyte sedimentation rate |journal=British Medical Journal |volume=286 |issue=6361 |pages=266 |date=January 1983 |pmid=6402065 |pmc=1546487 |doi=10.1136/bmj.286.6361.266}} 153. ^{{Cite GPnotebook|946536472|C-reactive protein}} 154. ^2730 Serum C-Reactive Protein values in Diabetics with Periodontal Disease {{webarchive|url=https://web.archive.org/web/20081220113411/http://iadr.confex.com/iadr/2008Toronto/techprogram/abstract_106289.htm |date=2008-12-20 }} A.R. Choudhury, and S. Rahman, Birdem, Diabetic Association of Bangladesh, Dhaka, Bangladesh. (the diabetics were not used to determine the reference ranges) 155. ^1 {{cite journal |vauthors=Sipahi T, Kara C, Tavil B, Inci A, Oksal A |title=Alpha-1 antitrypsin deficiency: an overlooked cause of late hemorrhagic disease of the newborn |journal=Journal of Pediatric Hematology/Oncology |volume=25 |issue=3 |pages=274–75 |date=March 2003 |pmid=12621252 |doi=10.1097/00043426-200303000-00019}} 156. ^1 Derived from mass values using molar mass of 44324.5 g/mol 157. ^1 Derived from molar values using molar mass of 44324.5 g/mol 158. ^{{cite web |url=http://www.mayomedicallaboratories.com/test-catalog/Clinical+and+Interpretive/83169 |title=Procalcitonin, Serum |date= |publisher= Mayo Clinic |access-date= 2015-03-01}} 159. ^1 2 3 4 5 6 7 8 9 The Society for American Clinical Laboratory Science > Chemistry Tests > Immunoglobulins {{webarchive|url=https://web.archive.org/web/20091015063657/http://www.ascls.org/labtesting/labchem.asp |date=2009-10-15 }} Retrieved on Nov 26, 2009 160. ^All values cited from Chronolab are given for ELISA 161. ^1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 chronolab.com > Autoantibodies associated with rheumatic diseases > Reference ranges Retrieved on April 29, 2010 162. ^1 {{Cite journal|vauthors=Rajkumar SV, Kyle RA, Therneau TM |title=Serum free light chain ratio is an independent risk factor for progression in monoclonal gammopathy of undetermined significance |journal=Blood |volume=106 |issue=3 |pages=812–17 |date=August 2005 |pmid=15855274 |pmc=1895159 |doi=10.1182/blood-2005-03-1038 |displayauthors=etal }} 163. ^{{Cite GPnotebook|309002307|Reference range (amylase)}} 164. ^1 2 3 Derived from mass using molar mass of 25,106 g/mol 165. ^{{cite journal |vauthors=Ageno W, Finazzi S, Steidl L, etal |title=Plasma measurement of D-dimer levels for the early diagnosis of ischemic stroke subtypes |journal=Archives of Internal Medicine |volume=162 |issue=22 |pages=2589–93 |year=2002 |pmid=12456231 |url=http://archinte.jamanetwork.com/article.aspx?volume=162&page=2589 |doi=10.1001/archinte.162.22.2589}} 166. ^{{cite journal |vauthors=Kline JA, Williams GW, Hernandez-Nino J |title=D-dimer concentrations in normal pregnancy: new diagnostic thresholds are needed |journal=Clinical Chemistry |volume=51 |issue=5 |pages=825–29 |date=May 2005 |pmid=15764641 |doi=10.1373/clinchem.2004.044883}} 167. ^1 {{cite journal |vauthors=Gardner MD, Scott R |title=Age- and sex-related reference ranges for eight plasma constituents derived from randomly selected adults in a Scottish new town |journal=Journal of Clinical Pathology |volume=33 |issue=4 |pages=380–85 |date=April 1980 |pmid=7400337 |pmc=1146084 |doi=10.1136/jcp.33.4.380}} 168. ^1 2 3 {{cite journal |vauthors=Finney H, Newman DJ, Price CP |title=Adult reference ranges for serum cystatin C, creatinine and predicted creatinine clearance |journal=Annals of Clinical Biochemistry |volume=37 |issue=1 |pages=49–59 |date=January 2000 |pmid=10672373 |doi=10.1258/0004563001901524}} 169. ^1 2 3 4 5 6 7 Derived from molar values by multiplying with the molar mass of 113.118 g/mol, and divided by 10.000 to adapt from μg/L to mg/dL 170. ^1 {{MedlinePlusEncyclopedia|003466|Glucose tolerance test}} 171. ^1 2 Derived from molar values using molar mass of 180g/mol 172. ^1 Derived from mass values using molar mass of 180g/mol 173. ^1 {{cite web|url=http://my.clevelandclinic.org/health/diseases_conditions/hic_Diabetes_Basics/hic_Understanding_Pre-Diabetes|title=Diabetes – Prevention|website=Cleveland Clinic|accessdate=2016-06-23}} Last revised 1/15/2013 174. ^1 2 3 Derived from mass values using molar mass of 90.08 g/mol 175. ^1 Derived from mass values using molar mass of 88.06 g/mol 176. ^1 {{EMedicine|article|2087982|Ketones}} 177. ^1 2 3 [https://books.google.com/books?id=BfdighlyGiwC&pg=PA700 Page 700] in: {{cite book|title=Medical Toxicology|author=Richard C. Dart|publisher=Lippincott Williams & Wilkins=year=2004|isbn=9780781728454|year=2004}} 178. ^The UK Electronic Medical Compendium recommends 0.4–0.8 mmol/l plasma lithium level in adults for prophylaxis of recurrent affective bipolar manic-depressive illness Camcolit 250 mg Lithium Carbonate {{Webarchive|url=https://web.archive.org/web/20160304000941/http://www.medicines.org.uk/emc/document.aspx?documentId=1239 |date=2016-03-04 }} Revision 2 December 2010, Retrieved 5 May 2011 179. ^1 {{cite journal|author=Amdisen A. |title=Clinical and serum level monitoring in lithium therapy and lithium intoxication|journal= J. Anal. Toxicol. |volume=2|issue=5|pages=193–202|year=1978|doi=10.1093/jat/2.5.193}} 180. ^1 R. Baselt, Disposition of Toxic Drugs and Chemicals in Man, 8th edition, Biomedical Publications, Foster City, CA, 2008, pp. 851–54. 181. ^One study ({{Cite journal| last1 = Solomon | first1 = D.| last2 = Ristow | first2 = W.| last3 = Keller | first3 = M.| last4 = Kane | first4 = J.| last5 = Gelenberg | first5 = A.| last6 = Rosenbaum | first6 = J.| last7 = Warshaw | first7 = M.| title = Serum lithium levels and psychosocial function in patients with bipolar I disorder| journal = The American Journal of Psychiatry| volume = 153| issue = 10| pages = 1301–07| year = 1996| pmid = 8831438 | doi=10.1176/ajp.153.10.1301}}) concluded a "low" dose of 0.4–0.6 mmol/L serum lithium treatment for patients with bipolar 1 disorder had less side effects, but a higher rate of relapse, than a "standard" dose of 0.8–1.0 mmol/l. However, a reanalysis of the same experimental data ({{Cite journal| last1 = Perlis | first1 = R.| last2 = Sachs | first2 = G.| last3 = Lafer | first3 = B.| last4 = Otto | first4 = M.| last5 = Faraone | first5 = S.| last6 = Kane | first6 = J.| last7 = Rosenbaum | first7 = J.| title = Effect of abrupt change from standard to low serum levels of lithium: A reanalysis of double-blind lithium maintenance data| journal = The American Journal of Psychiatry| volume = 159| issue = 7| pages = 1155–59| year = 2002| pmid = 12091193 | doi=10.1176/appi.ajp.159.7.1155}}) concluded the higher rate of relapse for the "low" dose was due to abrupt changes in the lithium serum levels{{synthesis inline|date=January 2012}} 182. ^1 {{cite book|title=Rosen's Emergency Medicine – Concepts and Clinical Practice|author1=John Marx |author2=Ron Walls |author3=Robert Hockberger |publisher=Elsevier Health Sciences|year=2013|isbn=9781455749874}} References{{reflist|30em}}External links
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1 : Blood tests |
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