| 词条 | FUB-APINACA |
| 释义 |
| IUPAC_name = N-(adamantan-1-yl)-1-[(4-fluorophenyl)methyl]-1H-indazole-3-carboxamide | image = FUB-APINACA.png | tradename = | pregnancy_AU = | pregnancy_US = | pregnancy_category = | legal_AU = | legal_CA = Schedule II | legal_UK = | legal_US = | legal_NZ = | routes_of_administration = | bioavailability = | protein_bound = | metabolism = | elimination_half-life = | excretion = | CAS_number_Ref = | CAS_number = | ATC_prefix = | ATC_suffix = | PubChem = 118796517 | ChemSpiderID = 30922497 | UNII = OF9Q7PH4UD | smiles = O=C(NC1(C[C@H]2C3)C[C@H]3C[C@H](C2)C1)C4=NN(CC5=CC=C(F)C=C5)C6=C4C=CC=C6 | StdInChI = 1S/C25H26FN3O/c26-20-7-5-16(6-8-20)15-29-22-4-2-1-3-21(22)23(28-29)24(30)27-25-12-17-9-18(13-25)11-19(10-17)14-25/h1-8,17-19H,9-15H2,(H,27,30)/t17-,18+,19-,25? | StdInChIKey = MWBHSNBPUSKVDD-LPSAYFBNSA-N | C=25 | H=26 | F=1 | N=3 | O=1 | molecular_weight = 403.5 g/mol }} FUB-APINACA or AFUBINACA (also known as FUB-AKB48) is an indazole-based synthetic cannabinoid that is presumed to be a potent agonist of the CB1 receptor and has been sold online as a designer drug.[1] It is an analogue of APINACA and 5F-APINACA where the pentyl chain has been replaced with fluorobenzyl. PharmacologyFUB-AKB-48 acts as a full agonist with a binding affinity of 1.06nM at CB1 and 0.174nM at CB2 cannabinoid receptors.[2] Legal statusSweden's public health agency suggested classifying FUB-APINACA as a hazardous substance on November 10, 2014.[3] It is also illegal in Alabama (listed as FUB-AKB48).[4] See also{{div col|colwidth=30em}}
References1. ^{{cite web | url=https://www.caymanchem.com/app/template/Product.vm/catalog/15937 | title=FUB-AKB48 | publisher=Cayman Chemical | accessdate=23 July 2015}} {{Cannabinoids}}{{cannabinoid-stub}}2. ^{{cite journal|first1=Cornelius|last1=Hess|first2=ClaraT.|last2=Schoeder|first3=Thanigaimalai|last3=Pillaiyar|first4=Burkhard|last4=Madea|title=Pharmacological evaluation of synthetic cannabinoids identified as constituents of spice|journal=Forensic Toxicology|date=1 July 2016|issn=1860-8965|pages=329–343|volume=34|issue=2|doi=10.1007/s11419-016-0320-2|first5=ChristaE.|last5=Müller|pmid=27429655|pmc=4929166}} 3. ^{{cite web | url=http://www.folkhalsomyndigheten.se/nyheter-och-press/nyhetsarkiv/2014/november/cannabinoider-foreslas-bli-klassade-som-halsofarlig-vara/ | title=Cannabinoider föreslås bli klassade som hälsofarlig vara | publisher=Folkhälsomyndigheten | accessdate=23 July 2015}} 4. ^[https://legiscan.com/AL/text/SB333/id/988417/Alabama-2014-SB333-Enrolled.pdf Alabama Senate Bill SB 333: Controlled Substances] 5 : Cannabinoids|Designer drugs|Indazoles|Fluoroarenes|Indazolecarboxamides |
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