| 词条 | Galactose binding lectin domain |
| 释义 |
| Symbol = Gal_Lectin | Name = Gal_Lectin | image = | width = | caption = solution structure of the gal_lectin domain of mouse latrophilin-1 gpcr | Pfam = PF02140 | Pfam_clan = | InterPro = IPR000922 | SMART = | PROSITE = | MEROPS = | SCOP = | TCDB = | OPM family = | OPM protein = | CAZy = | CDD = }} In molecular biology, the galactose binding lectin domain is a protein domain. It is found in many proteins including the lectin purified from sea urchin (Anthocidaris crassispina) eggs, SUEL. This lectin exists as a disulfide-linked homodimer of two subunits; the dimeric form is essential for hemagglutination activity.[1] The sea urchin egg lectin (SUEL) forms a new class of lectins. Although SUEL was first isolated as a D-galactoside binding lectin, it was later shown that it binds to L-rhamnose preferentially.[1][2] L-rhamnose and D-galactose share the same hydroxyl group orientation at C2 and C4 of the pyranose ring structure. A cysteine-rich domain (the galactose binding lectin domain) homologous to the SUEL protein has been identified in the following proteins:[3][4][5]
References1. ^1 {{cite journal |vauthors=Ozeki Y, Matsui T, Suzuki M, Titani K | title = Amino acid sequence and molecular characterization of a D-galactoside-specific lectin purified from sea urchin (Anthocidaris crassispina) eggs | journal = Biochemistry | volume = 30 | issue = 9 | pages = 2391–4 |date=March 1991 | pmid = 2001368 | doi = 10.1021/bi00223a014 | url = }} {{InterPro content|IPR000922}}2. ^1 {{cite journal |vauthors=Hosono M, Ishikawa K, Mineki R, Murayama K, Numata C, Ogawa Y, Takayanagi Y, Nitta K | title = Tandem repeat structure of rhamnose-binding lectin from catfish (Silurus asotus) eggs | journal = Biochim. Biophys. Acta | volume = 1472 | issue = 3 | pages = 668–75 |date=November 1999 | pmid = 10564781 | doi = 10.1016/S0304-4165(99)00185-3| url = }} 3. ^{{cite journal |vauthors=Lelianova VG, Davletov BA, Sterling A, Rahman MA, Grishin EV, Totty NF, Ushkaryov YA | title = Alpha-latrotoxin receptor, latrophilin, is a novel member of the secretin family of G protein-coupled receptors | journal = J. Biol. Chem. | volume = 272 | issue = 34 | pages = 21504–8 |date=August 1997 | pmid = 9261169 | doi = 10.1074/jbc.272.34.21504| url = }} 4. ^{{cite journal |vauthors=Tateno H, Saneyoshi A, Ogawa T, Muramoto K, Kamiya H, Saneyoshi M | title = Isolation and characterization of rhamnose-binding lectins from eggs of steelhead trout (Oncorhynchus mykiss) homologous to low density lipoprotein receptor superfamily | journal = J. Biol. Chem. | volume = 273 | issue = 30 | pages = 19190–7 |date=July 1998 | pmid = 9668106 | doi = 10.1074/jbc.273.30.19190| url = }} 5. ^1 {{cite journal |vauthors=Krasnoperov V, Bittner MA, Holz RW, Chepurny O, Petrenko AG | title = Structural requirements for alpha-latrotoxin binding and alpha-latrotoxin-stimulated secretion. A study with calcium-independent receptor of alpha-latrotoxin (CIRL) deletion mutants | journal = J. Biol. Chem. | volume = 274 | issue = 6 | pages = 3590–6 |date=February 1999 | pmid = 9920906 | doi = 10.1074/jbc.274.6.3590| url = }} 1 : Protein families |
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