“Genetics of tuberculosis”的意思、由来-开放百科全书

The nature of the host-pathogen interaction between humans and Mycobacterium tuberculosis is considered to have a genetic component. A group of rare disorders called Mendelian Susceptibility to Mycobacterial Diseases (MSMD) was observed in a subset of individuals with a genetic defect that results in increased susceptibility to Mycobacterial infection.

Genome-wide association studies

Early case and twin studies have indicated that genetic component are important in host susceptibility to Mycobacterial Tuberculosis. Recent Genome-wide association studies (GWAS) have identified three genetic risk loci, including at positions 11p13 and 18q11.^[1]^[2] As is common in GWAS, the variants discovered have moderate effect sizes.

References

1. ^{{cite journal|last1=Thye|first1=T|last2=Owusu-Dabo|first2=E|last3=Vannberg|first3=FO|last4=van Crevel|first4=R|last5=Curtis|first5=J|last6=Sahiratmadja|first6=E|last7=Balabanova|first7=Y|last8=Ehmen|first8=C|last9=Muntau|first9=B|last10=Ruge|first10=G|last11=Sievertsen|first11=J|last12=Gyapong|first12=J|last13=Nikolayevskyy|first13=V|last14=Hill|first14=PC|last15=Sirugo|first15=G|last16=Drobniewski|first16=F|last17=van de Vosse|first17=E|last18=Newport|first18=M|last19=Alisjahbana|first19=B|last20=Nejentsev|first20=S|last21=Ottenhoff|first21=TH|last22=Hill|first22=AV|last23=Horstmann|first23=RD|last24=Meyer|first24=CG|title=Common variants at 11p13 are associated with susceptibility to tuberculosis.|journal=Nature Genetics|date=5 February 2012|volume=44|issue=3|pages=257–9|pmid=22306650|doi=10.1038/ng.1080|pmc=3427019}}
2. ^{{cite journal|last1=Thye|first1=T|last2=Vannberg|first2=FO|last3=Wong|first3=SH|last4=Owusu-Dabo|first4=E|last5=Osei|first5=I|last6=Gyapong|first6=J|last7=Sirugo|first7=G|last8=Sisay-Joof|first8=F|last9=Enimil|first9=A|last10=Chinbuah|first10=MA|last11=Floyd|first11=S|last12=Warndorff|first12=DK|last13=Sichali|first13=L|last14=Malema|first14=S|last15=Crampin|first15=AC|last16=Ngwira|first16=B|last17=Teo|first17=YY|last18=Small|first18=K|last19=Rockett|first19=K|last20=Kwiatkowski|first20=D|last21=Fine|first21=PE|last22=Hill|first22=PC|last23=Newport|first23=M|last24=Lienhardt|first24=C|last25=Adegbola|first25=RA|last26=Corrah|first26=T|last27=Ziegler|first27=A|last28=African TB Genetics|first28=Consortium|last29=Wellcome Trust Case Control|first29=Consortium|last30=Morris|first30=AP|last31=Meyer|first31=CG|last32=Horstmann|first32=RD|last33=Hill|first33=AV|title=Genome-wide association analyses identifies a susceptibility locus for tuberculosis on chromosome 18q11.2.|journal=Nature Genetics|date=September 2010|volume=42|issue=9|pages=739–41|pmid=20694014|doi=10.1038/ng.639|pmc=4975513}}