RGS is the abbreviation of:

• Burgos Airport, Spain, by IATA airport code
• Congregation of Our Lady of Charity of the Good Shepherd
• Raffles Girls' School (Secondary)
• Rapid Global School, Uttar Pradesh, India
• Redland Green School, Bristol
• Regulator of G protein signalling
• Reigate Grammar School
• Remote Graphics Software, Remote desktop protocol by Hewlett Packard
• Restless Genital Syndrome, a spontaneous, persistent, and uncontrollable genital arousal in women, unrelated to any feelings of sexual desire
• RGS Atalanta, a revival of the Atalanta automobile after the World War II
• Rio Game Show, original name of Brasil Game Show (BGS)
• Rio Grande Southern Railroad, reporting mark RGS
• Ripon Grammar School
• Rosgosstrakh
• Royal Geographical Society
• Royal Grammar School (disambiguation), several schools in the United Kingdom

• Spinnerette
• Spinnerette (comics)
• Spinners
• Spinners (album)
• Spinners (disambiguation)
• Spinner shark
• Spinner's weasel
• Spinnet
• Spinney Hill
• Spinney Hills
• Spinney (Kettering BC Ward)
• Spinneys
• Spinnin'
• Spinning band distillation
• Spinning beachball
• Spinning Boris
• Spinning count
• Spinning (cycling)
• Spinning death
• Spinning disk confocal microscopy
• Spinning (djing)
• Spinning door
• Spinning Dragons (roller coaster)
• Spinning Dragons (rollercoaster)
• Spinning dust