| 词条 | Glycoside hydrolase family 4 |
| 释义 |
| Symbol = Glyco_hydro_4 | Name = Family 4 glycosyl hydrolase | image = PDB 1up6 EBI.jpg | width = | caption = Structure of the 6-phospho-beta glucosidase from Thermotoga maritima at 2.55 angstrom resolution in the tetragonal form with manganese, NAD+ and glucose-6-phosphate | Pfam = PF02056 | Pfam_clan = CL0063 | SMART = | PROSITE = PDOC01027 | MEROPS = | SCOP = 1obb | TCDB = | OPM family = | OPM protein = | CAZy = GH4 | CDD = | InterPro = IPR001088 }}{{Infobox protein family | Symbol = Glyco_hydro_4C | Name = Family 4 glycosyl hydrolase C-terminal domain | image = | width = | caption = | Pfam = PF11975 | Pfam_clan = CL0341 | InterPro = | SMART = | PROSITE = PDOC01027 | MEROPS = | SCOP = 1obb | TCDB = | OPM family = | OPM protein = | CAZy = GH4 | CDD = }} In molecular biology, glycoside hydrolase family 4 is a family of glycoside hydrolases. Glycoside hydrolases {{EC number|3.2.1.}} are a widespread group of enzymes that hydrolyse the glycosidic bond between two or more carbohydrates, or between a carbohydrate and a non-carbohydrate moiety. A classification system for glycoside hydrolases, based on sequence similarity, has led to the definition of >100 different families.[1][2][3] This classification is available on the CAZy web site,[4][5] and also discussed at CAZypedia, an online encyclopedia of carbohydrate active enzymes.[6][7]Glycoside hydrolase family 4 CAZY GH_4 comprises enzymes with several known activities; 6-phospho-beta-glucosidase ({{EC number|3.2.1.86}}); 6-phospho-alpha-glucosidase ({{EC number|3.2.1.122}}); alpha-galactosidase ({{EC number|3.2.1.22}}). 6-phospho-alpha-glucosidase requires both NAD(H) and divalent metal (Mn2+, Fe2+, Co2+, or Ni2+) for activity.[8] External referencesGH4 in CAZypediaReferences1. ^{{cite journal | vauthors = Henrissat B, Callebaut I, Fabrega S, Lehn P, Mornon JP, Davies G | title = Conserved catalytic machinery and the prediction of a common fold for several families of glycosyl hydrolases | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 92 | issue = 15 | pages = 7090–4 | date = July 1995 | pmid = 7624375 | pmc = 41477 | doi = 10.1073/pnas.92.15.7090 }} {{InterPro content|IPR001088}}{{Sugar hydrolases}}{{Enzymes}}{{Portal bar|Molecular and Cellular Biology|border=no}}2. ^{{cite journal | vauthors = Davies G, Henrissat B | title = Structures and mechanisms of glycosyl hydrolases | journal = Structure | volume = 3 | issue = 9 | pages = 853–9 | date = September 1995 | pmid = 8535779 | doi = 10.1016/S0969-2126(01)00220-9 }} 3. ^{{cite journal | vauthors = Henrissat B, Bairoch A | title = Updating the sequence-based classification of glycosyl hydrolases | journal = The Biochemical Journal | volume = 316 ( Pt 2) | issue = Pt 2 | pages = 695–6 | date = June 1996 | pmid = 8687420 | pmc = 1217404 }} 4. ^{{Cite web|url=http://www.cazy.org/|title=Home|last=|first=|date=|website=CAZy.org|language=en|archive-url=|archive-date=|dead-url=|access-date=2018-03-06}} 5. ^{{cite journal | vauthors = Lombard V, Golaconda Ramulu H, Drula E, Coutinho PM, Henrissat B | title = The carbohydrate-active enzymes database (CAZy) in 2013 | journal = Nucleic Acids Research | volume = 42 | issue = Database issue | pages = D490-5 | date = January 2014 | pmid = 24270786 | pmc = 3965031 | doi = 10.1093/nar/gkt1178 | url = https://academic.oup.com/nar/article/42/D1/D490/1057423 }} 6. ^{{Cite web|url=http://www.cazypedia.org/index.php/Glycoside_Hydrolase_Family_4|title=Glycoside Hydrolase Family 4|last=|first=|date=|website=CAZypedia.org|language=en|archive-url=|archive-date=|dead-url=|access-date=2018-03-06}} 7. ^{{cite journal | title = Ten years of CAZypedia: a living encyclopedia of carbohydrate-active enzymes | journal = Glycobiology | volume = 28 | issue = 1 | pages = 3–8 | date = December 2018 | pmid = 29040563 | doi = 10.1093/glycob/cwx089 | author1 = CAZypedia Consortium }} 8. ^{{cite journal | vauthors = Thompson J, Pikis A, Ruvinov SB, Henrissat B, Yamamoto H, Sekiguchi J | title = The gene glvA of Bacillus subtilis 168 encodes a metal-requiring, NAD(H)-dependent 6-phospho-alpha-glucosidase. Assignment to family 4 of the glycosylhydrolase superfamily | journal = The Journal of Biological Chemistry | volume = 273 | issue = 42 | pages = 27347–56 | date = October 1998 | pmid = 9765262 | doi = 10.1074/jbc.273.42.27347 }} 3 : EC 3.2.1|GH family|Protein families |
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