| 词条 | Glycoside hydrolase family 63 |
| 释义 |
| Symbol = Glyco_hydro_63 | Name = Mannosyl oligosaccharide glucosidase | image = | width = | caption = | Pfam = PF03200 | Pfam_clan = CL0059 | InterPro = IPR004888 | SMART = | PROSITE = | MEROPS = | SCOP = | TCDB = | OPM family = | OPM protein = | CAZy = GH63 | CDD = | Membranome family = 527 }} In molecular biology, glycoside hydrolase family 63 is a family of glycoside hydrolases. Glycoside hydrolases {{EC number|3.2.1.}} are a widespread group of enzymes that hydrolyse the glycosidic bond between two or more carbohydrates, or between a carbohydrate and a non-carbohydrate moiety. A classification system for glycoside hydrolases, based on sequence similarity, has led to the definition of >100 different families.[1][2][3] This classification is available on the CAZy web site,[4][5] and also discussed at CAZypedia, an online encyclopedia of carbohydrate active enzymes.[6][7]Glycosyl hydrolase family 63 (CAZY GH_63) is a family of eukaryotic enzymes. They catalyse the specific cleavage of the non-reducing terminal glucose residue from Glc(3)Man(9)GlcNAc(2). Mannosyl oligosaccharide glucosidase {{EC number|3.2.1.106}} is the first enzyme in the N-linked oligosaccharide processing pathway. References1. ^{{cite journal|vauthors=Henrissat B, Callebaut I, Fabrega S, Lehn P, Mornon JP, Davies G|date=July 1995|title=Conserved catalytic machinery and the prediction of a common fold for several families of glycosyl hydrolases|journal=Proceedings of the National Academy of Sciences of the United States of America|volume=92|issue=15|pages=7090–4|doi=10.1073/pnas.92.15.7090|pmc=41477|pmid=7624375}} {{InterPro content|IPR004888}}{{Sugar hydrolases}}{{Enzymes}}{{Portal bar|Molecular and Cellular Biology|border=no}}2. ^{{cite journal|vauthors=Davies G, Henrissat B|date=September 1995|title=Structures and mechanisms of glycosyl hydrolases|journal=Structure|volume=3|issue=9|pages=853–9|doi=10.1016/S0969-2126(01)00220-9|pmid=8535779}} 3. ^{{cite journal|vauthors=Henrissat B, Bairoch A|date=June 1996|title=Updating the sequence-based classification of glycosyl hydrolases|journal=The Biochemical Journal|volume=316 ( Pt 2)|issue=Pt 2|pages=695–6|pmc=1217404|pmid=8687420}} 4. ^{{Cite web|url=http://www.cazy.org/|title=Home|last=|first=|date=|website=CAZy.org|language=en|archive-url=|archive-date=|dead-url=|access-date=2018-03-06}} 5. ^{{cite journal|vauthors=Lombard V, Golaconda Ramulu H, Drula E, Coutinho PM, Henrissat B|date=January 2014|title=The carbohydrate-active enzymes database (CAZy) in 2013|url=https://academic.oup.com/nar/article/42/D1/D490/1057423|journal=Nucleic Acids Research|volume=42|issue=Database issue|pages=D490–5|doi=10.1093/nar/gkt1178|pmid=24270786}} 6. ^{{Cite web|url=http://www.cazypedia.org/index.php/Glycoside_Hydrolase_Family_63|title=Glycoside Hydrolase Family 63|last=|first=|date=|website=CAZypedia.org|language=en|archive-url=|archive-date=|dead-url=|access-date=2018-03-06}} 7. ^{{cite journal|vauthors=|date=December 2018|title=Ten years of CAZypedia: a living encyclopedia of carbohydrate-active enzymes|journal=Glycobiology|volume=28|issue=1|pages=3–8|doi=10.1093/glycob/cwx089|pmid=29040563}} 3 : EC 3.2.1|GH family|Protein families |
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