| 词条 | Glycoside hydrolase family 78 |
| 释义 |
| Symbol = Bac_rhamnosid | Name = Bacterial alpha-L-rhamnosidase | image = | width = | caption = | Pfam = PF05592 | Pfam_clan = CL0059 | InterPro = IPR008902 | SMART = | PROSITE = | MEROPS = | SCOP = | TCDB = | OPM family = | OPM protein = | CAZy = GH78 | CDD = }} In molecular biology, glycoside hydrolase family 78 is a family of glycoside hydrolases. Glycoside hydrolases {{EC number|3.2.1.}} are a widespread group of enzymes that hydrolyse the glycosidic bond between two or more carbohydrates, or between a carbohydrate and a non-carbohydrate moiety. A classification system for glycoside hydrolases, based on sequence similarity, has led to the definition of >100 different families.[1][2][3] This classification is available on the CAZy web site,[4][5] and also discussed at CAZypedia, an online encyclopedia of carbohydrate active enzymes.[6][7]Glycoside hydrolase family 78 CAZY GH_78 includes enzymes with α-L-rhamnosidase {{EC number|3.2.1.40}} activity. This family includes bacterial rhamnosidase A and B enzymes. L-Rhamnose is abundant in biomass as a common constituent of glycolipids and glycosides, such as plant pigments, pectic polysaccharides, gums or biosurfactants. Some rhamnosides are important bioactive compounds. For example, terpenyl glycosides, the glycosidic precursor of aromatic terpenoids, act as important flavouring substances in grapes. Other rhamnosides act as cytotoxic rhamnosylated terpenoids, as signal substances in plants or play a role in the antigenicity of pathogenic bacteria.[8] References1. ^{{cite journal|vauthors=Henrissat B, Callebaut I, Fabrega S, Lehn P, Mornon JP, Davies G|date=July 1995|title=Conserved catalytic machinery and the prediction of a common fold for several families of glycosyl hydrolases|journal=Proceedings of the National Academy of Sciences of the United States of America|volume=92|issue=15|pages=7090–4|doi=10.1073/pnas.92.15.7090|pmc=41477|pmid=7624375}} {{InterPro content|IPR008902}}{{Sugar hydrolases}}{{Enzymes}}{{Portal bar|Molecular and Cellular Biology|border=no}}2. ^{{cite journal|vauthors=Davies G, Henrissat B|date=September 1995|title=Structures and mechanisms of glycosyl hydrolases|journal=Structure|volume=3|issue=9|pages=853–9|doi=10.1016/S0969-2126(01)00220-9|pmid=8535779}} 3. ^{{cite journal|vauthors=Henrissat B, Bairoch A|date=June 1996|title=Updating the sequence-based classification of glycosyl hydrolases|journal=The Biochemical Journal|volume=316 ( Pt 2)|issue=Pt 2|pages=695–6|pmc=1217404|pmid=8687420}} 4. ^{{Cite web|url=http://www.cazy.org/|title=Home|last=|first=|date=|website=CAZy.org|language=en|archive-url=|archive-date=|dead-url=|access-date=2018-03-06}} 5. ^{{cite journal|vauthors=Lombard V, Golaconda Ramulu H, Drula E, Coutinho PM, Henrissat B|date=January 2014|title=The carbohydrate-active enzymes database (CAZy) in 2013|url=https://academic.oup.com/nar/article/42/D1/D490/1057423|journal=Nucleic Acids Research|volume=42|issue=Database issue|pages=D490–5|doi=10.1093/nar/gkt1178|pmid=24270786}} 6. ^{{Cite web|url=http://www.cazypedia.org/index.php/Glycoside_Hydrolase_Family_78|title=Glycoside Hydrolase Family 78|last=|first=|date=|website=CAZypedia.org|language=en|archive-url=|archive-date=|dead-url=|access-date=2018-03-06}} 7. ^{{cite journal|vauthors=|date=December 2018|title=Ten years of CAZypedia: a living encyclopedia of carbohydrate-active enzymes|journal=Glycobiology|volume=28|issue=1|pages=3–8|doi=10.1093/glycob/cwx089|pmid=29040563}} 8. ^{{cite journal |vauthors=Zverlov VV, Hertel C, Bronnenmeier K, Hroch A, Kellermann J, Schwarz WH | title = The thermostable alpha-L-rhamnosidase RamA of Clostridium stercorarium: biochemical characterization and primary structure of a bacterial alpha-L-rhamnoside hydrolase, a new type of inverting glycoside hydrolase | journal = Mol. Microbiol. | volume = 35 | issue = 1 | pages = 173–9 |date=January 2000 | pmid = 10632887 | doi = 10.1046/j.1365-2958.2000.01691.x| url = }} 3 : EC 3.2.1|GH family|Protein families |
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