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| Name = Glycosyltransferase DesVII
| EC_number = 2.4.1.277
| CAS_number =
| IUBMB_EC_number = 2/4/1/277
| GO_code =
| image =
| width =
| caption =
}}Glycosyltransferase DesVII ({{EC number|2.4.1.277}}, DesVII) is an enzyme with systematic name dTDP-3-dimethylamino-3,4,6-trideoxy-alpha-D-glucopyranose:10-deoxymethynolide 3-dimethylamino-4,6-dideoxy-alpha-D-glucosyltransferase.[1][2][3] This enzyme catalyses the following chemical reaction
dTDP-3-dimethylamino-3,4,6-trideoxy-alpha-D-glucopyranose + 10-deoxymethynolidedTDP + 10-deoxymethymycin
DesVII is the glycosyltransferase responsible for the attachment of TDP-D-desosamine to macrolactones of varied ring sizes.
References
1. ^{{cite journal | title = Characterization of glycosyltransferase DesVII and its auxiliary partner protein DesVIII in the methymycin/picromycin biosynthetic pathway |author1 = Borisova, S.A. |author2 =Liu, H.W. |journal = Biochemistry |year = 2010 |volume = 49 |pages = 8071–8084 |pmid = 20695498 | doi = 10.1021/bi1007657 | issue = 37 | pmc = 2939310}}
2. ^{{cite journal | title = Glycosylation of acyclic and cyclic aglycone substrates by macrolide glycosyltransferase DesVII/DesVIII: analysis and implications |author1 = Borisova, S.A. |author2 =Kim, H.J. |author3 =Pu, X. |author4 =Liu, H.W. |journal = ChemBioChem |year = 2008 |volume = 9 |pages = 1554–1558 |pmid = 18548476 | doi = 10.1002/cbic.200800155 | issue = 10 | pmc=4400176}}
3. ^{{cite journal | title = Functional analysis of desVIII homologues involved in glycosylation of macrolide antibiotics by interspecies complementation |author1 = Hong, J.S. |author2 =Park, S.J. |author3 =Parajuli, N. |author4 =Park, S.R. |author5 =Koh, H.S. |author6 =Jung, W.S. |author7 =Choi, C.Y. |author8 =Yoon, Y.J. | journal = Gene |year = 2007 |volume = 386 |pages = 123–130 |pmid = 17049185 | doi = 10.1016/j.gene.2006.08.021 | issue = 1–2}}
2. ^{{cite journal | title = Glycosylation of acyclic and cyclic aglycone substrates by macrolide glycosyltransferase DesVII/DesVIII: analysis and implications |author1 = Borisova, S.A. |author2 =Kim, H.J. |author3 =Pu, X. |author4 =Liu, H.W. |journal = ChemBioChem |year = 2008 |volume = 9 |pages = 1554–1558 |pmid = 18548476 | doi = 10.1002/cbic.200800155 | issue = 10 | pmc=4400176}}
3. ^{{cite journal | title = Functional analysis of desVIII homologues involved in glycosylation of macrolide antibiotics by interspecies complementation |author1 = Hong, J.S. |author2 =Park, S.J. |author3 =Parajuli, N. |author4 =Park, S.R. |author5 =Koh, H.S. |author6 =Jung, W.S. |author7 =Choi, C.Y. |author8 =Yoon, Y.J. | journal = Gene |year = 2007 |volume = 386 |pages = 123–130 |pmid = 17049185 | doi = 10.1016/j.gene.2006.08.021 | issue = 1–2}}
External links
- {{MeshName|Glycosyltransferase+DesVII}}
1 : EC 2.4.1
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