请输入您要查询的百科知识：

　

词条 GPR 120
释义

  1. References

GPR 120 is a G protein-coupled receptor (GPCR) and the putative receptor for omega-3 fatty acids including Docosahexaenoic acid (DHA) and Eicosapentaenoic acid (EPA).[1][2] GPR 120 was among a number of free fatty acid receptors only recently discovered from the human genome database utilizing the GPCR deorphanizing strategy.[3] Binding to the GPR 120 receptor is one of the many putative mechanisms of action for the potential health benefits of consuming omega-3 fatty acids. GPR 120 has specifically shown a role in the in-vivo anti-inflammatory and insulin-sensitizing effects of DHA and EPA in macrophages. Macrophage mediated inflammation is a key player in the pathophysiology of metabolic syndrome related disorders, including diabetes and atherosclerosis. GPR 120 is also a key regulator of adipogenesis, including adipocyte development and differentiation.[4]

References

1. ^{{cite journal |pages=687–98 |doi=10.1016/j.cell.2010.07.041 |pmc=2956412 |title=GPR120 is an Omega-3 Fatty Acid Receptor Mediating Potent Anti-inflammatory and Insulin-Sensitizing Effects |year=2010 |last1=Oh |first1=Da Young |last2=Talukdar |first2=Saswata |last3=Bae |first3=Eun Ju |last4=Imamura |first4=Takeshi |last5=Morinaga |first5=Hidetaka |last6=Fan |first6=Wuqiang |last7=Li |first7=Pingping |last8=Lu |first8=Wendell J. |last9=Watkins |first9=Steven M. |last10=Olefsky |first10=Jerrold M. |journal=Cell |volume=142 |issue=5 |pmid=20813258|display-authors=8 }}
2. ^{{cite journal |pages=427–34 |doi=10.1007/s00210-008-0390-8 |title=Distribution and regulation of protein expression of the free fatty acid receptor GPR120 |year=2009 |last1=Miyauchi |first1=Satoshi |last2=Hirasawa |first2=Akira |last3=Iga |first3=Tomoyo |last4=Liu |first4=Ning |last5=Itsubo |first5=Chisato |last6=Sadakane |first6=Keiko |last7=Hara |first7=Takafumi |last8=Tsujimoto |first8=Gozoh |journal=Naunyn-Schmiedeberg's Archives of Pharmacology |volume=379 |issue=4 |pmid=19145429}}
3. ^{{cite journal |pmid=18827341 |year=2008 |last1=Hirasawa |first1=Akira |last2=Hara |first2=Takafumi |last3=Katsuma |first3=Susumu |last4=Adachi |first4=Tetsuya |last5=Tsujimoto |first5=Gozoh |title=Free Fatty Acid Receptors and Drug Discovery |volume=31 |issue=10 |pages=1847–51 |journal=Biological & Pharmaceutical Bulletin |url=http://joi.jlc.jst.go.jp/JST.JSTAGE/bpb/31.1847?from=PubMed |doi=10.1248/bpb.31.1847}}
4. ^{{cite journal |pages=591–7 |doi=10.1016/j.bbrc.2007.01.028 |title=The regulation of adipogenesis through GPR120 |year=2007 |last1=Gotoh |first1=Chizu |last2=Hong |first2=Yeon-Hee |last3=Iga |first3=Tomoyo |last4=Hishikawa |first4=Daisuke |last5=Suzuki |first5=Yasuki |last6=Song |first6=Sang-Houn |last7=Choi |first7=Ki-Choon |last8=Adachi |first8=Tetsuya |last9=Hirasawa |first9=Akira |last10=Tsujimoto |first10=Gozoh |last11=Sasaki |first11=Shin-Ichi |last12=Roh |first12=Sang-Gun |journal=Biochemical and Biophysical Research Communications |volume=354 |issue=2 |pmid=17250804|display-authors=8 }}

1 : G protein-coupled receptors
随便看

　

开放百科全书收录14589846条英语、德语、日语等多语种百科知识，基本涵盖了大多数领域的百科知识，是一部内容自由、开放的电子版国际百科全书。

　

Copyright © 2023 OENC.NET All Rights Reserved
京ICP备2021023879号 更新时间：2024/9/27 19:18:20