Grand Duo may refer to

• Violin Sonata in A major, D 574 (Schubert)
• Sonata in C major for piano four-hands, D 812 (Schubert)
• Grand Duo concertant (Chopin and Franchomme), cello and piano
• Gran Duo Concertante, two double basses and orchestra by Bottesini
• Grand Duo Concertant (Weber), clarinet and piano

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