| 词条 | GSK-789,472 |
| 释义 |
| verifiedrevid = 425143798 | IUPAC_name = 4,5-dihydro-1-phenyl-3-(piperidin-2-yl)methylimidazol-2(1H)one | image = GSK-789,472.svg | width = 200 | tradename = | pregnancy_category = | legal_status = | routes_of_administration = | bioavailability = | protein_bound = | metabolism = | elimination_half-life = | excretion = | CAS_number = | ATC_prefix = none | ATC_suffix = | PubChem = | ChemSpiderID = 59650715 | C=15 | H=21 | N=3 | O=1 | molecular_weight = 259.168 g/mol | smiles = O=C1N(CC2NCCCC2)CCN1C3=CC=CC=C3 | StdInChI = 1S/C15H21N3O/c19-15-17(12-13-6-4-5-9-16-13)10-11-18(15)14-7-2-1-3-8-14/h1-3,7-8,13,16H,4-6,9-12H2 | StdInChIKey = MGPOBHIJMZQPIK-UHFFFAOYSA-N }}GSK-789,472 is a drug which acts as both a potent and selective partial agonist at the dopamine receptor D2, as well as an antagonist at the related D3 subtype, but with good selectivity over D4 and other unrelated receptors.[1] References1. ^{{cite journal |vauthors=Holmes IP, Blunt RJ, Lorthioir OE, Blowers SM, Gribble A, Payne AH, Stansfield IG, Wood M, Woollard PM, Reavill C, Howes CM, Micheli F, Di Fabio R, Donati D, Terreni S, Hamprecht D, Arista L, Worby A, Watson SP |title=The identification of a selective dopamine D2 partial agonist, D3 antagonist displaying high levels of brain exposure |journal=Bioorganic & Medicinal Chemistry Letters |volume=20 |issue=6 |pages=2013–6 |date=March 2010 |pmid=20153647 |doi=10.1016/j.bmcl.2010.01.090 |url=}} {{Dopaminergics}}{{nervous-system-drug-stub}} 4 : Dopamine agonists|Dopamine antagonists|Imidazolidinones|Piperidines |
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