| 词条 | Gustavo Turecki |
| 释义 |
| name = Gustavo Turecki MD-Ph.D. | image =Gustavo Turecki.jpg | image_size = | alt = Gustavo Turecki | caption = Gustavo Turecki | birth_date = {{birth date and age|1965|05|11}} | residence = Canada | nationality = Canadian | spouse = | children = | era = | sub_discipline = | movement = | denomination = | education = McGill University | alma_mater =McGill University, Douglas Mental Health University Institute | thesis_title = | thesis_url = | thesis_year = | doctoral_students = | notable_students = | main_interests = | notable_works = | notable_ideas = | influences = | influenced = | website = https://mgss.ca | footnotes = | awards = Prix Léo Pariseau for biological and health sciences, Acfas (2016); NARSAD Distinguished Investigator Award, Brain and Behaviour Research Foundation (2016); ACNP Joel Elkes Award (2015); AFSP Research Career Award (2012); Heinz Lehmann Award, CCNP (2012); Radio-Canada Scientist of the Year Award (2009); NARSAD Oxley Foundation Investigator Award (2009); AFSP Distinguished Investigator Award (2009 & 2006). }}Gustavo Turecki (born May 11, 1965) is a Canadian psychiatrist and professor at McGill University. He holds a Tier 1 Canada Research Chair Tier in Major Depressive Disorder and Suicide. He is the sitting Chair of the Department of Psychiatry,[1] and works at the Douglas Mental Health University Institute, where he heads both the McGill Group for Suicide Studies[2] and the Depressive Disorders Program. He is also the director of the FRQS/FRQSC-funded Quebec Network on Suicide, Mood Disorders and Related Disorders,[3] and the co-director of the Douglas Bell-Canada Brain Bank.[4] As a clinician and neuroscientist, his research focuses on examining the influence of life experiences on brain function, and their relationship to depression and suicide risk. Among his major contributions, published in over 400 peer-reviewed publications and book chapters,[5] is the first description of the long-term impact of childhood abuse on the brain, particularly how it affects the activity of key genes involved in stress-response. Scientific contributionsTurecki's neurobiological work has focused strongly on the processes underlying depression and suicide. A defining moment in his career came from a collaboration with Michael Meaney and Moshe Szyf, in which they uncovered that early-life adversity epigenetically regulates the glucocorticoid receptor gene, a key component of response to stress.[6] This groundbreaking study helped to reconcile the longstanding debate about the relative influences of genes and environment on behaviour (‘nature vs. nurture’ debate), and garnered international attention, leading to Turecki's selection as the scientist of the year by Radio Canada/Canadian Broadcasting Corporation in 2009, along with Meaney and Szyf. Turecki's further research on the human brain explored the epigenetic control of genes related to stress-response systems, such as the hypothalamus- pituitary-adrenal (HPA) axis, particularly in association with childhood abuse and suicide.[7][8] The promising results obtained in studying the epigenetic control of the HPA axis prompted Turecki to study the role of epigenetics in another pathway, the polyamine stress response, which his team had already shown to be linked to suicide risk.[9] More recently, and in parallel to the classic epigenetic studies focusing on DNA and histone methylation, Turecki's focus has expanded to non-coding RNAs and their involvement in depression and suicide,[10] as well as in response to antidepressants.[11] Turecki also conducts work aiming at refining the depression and suicide phenotype. His clinical work focuses on depression. He leads the Depressive Disorders Program, a clinical group that treats patients affected with major depression and integrates research projects into clinical practice. Two key aspects of this work are exploring how impulsive-aggressive behaviours contribute to suicide risk,[12] and implementing novel protocols and standards in the field. Turecki's ongoing research endeavours have a strong impact on international neuropsychiatric research. His clinical intervention protocols have helped to improve patient care, and his laboratory has become an international leader in the investigation of the neurobiology of suicide, focusing on functional genomics, epigenetics and other molecular factors. His contributions in creating and managing the Suicide Brain Bank within the Douglas Bell-Canada Brain Bank[13] has allowed researchers from around the world to access unique and valuable human tissues. Personal lifeTurecki is married and has three children. He was born in La Plata, Argentina and moved to Montreal in 1994.{{citation needed|date=October 2017}} Recognition of workTurecki is currently an FRQS Chercheur National.[14] His contributions have also been recognized through numerous prizes and awards.
Selected publicationsNeurobiology studies
Clinical and behavioural studies of depression and suicide
References1. ^{{cite web|url=https://www.mcgill.ca/psychiatry/research|title=Research | Department of Psychiatry - McGill University|publisher=mcgill.ca|accessdate=2014-12-09}} 2. ^{{cite web|url=http://mgss.ca|title=McGill Group for Suicide Studies|publisher=mgss.ca|accessdate=2014-12-09}} 3. ^{{cite web|url=http://reseausuicide.qc.ca|title=Quebec Network on Suicide, Mood Disorders and Related Disorders RQSHA|publisher=reseausuicide.qc.ca|accessdate=2014-12-09}} 4. ^{{cite web|url=http://douglasbrainbank.ca|title=The Brain Bank | The Douglas Bell Canada Brain Bank|publisher=douglasbrainbank.ca|accessdate=2014-12-09}} 5. ^{{cite web|url=https://www.ncbi.nlm.nih.gov/pubmed/?term=turecki+g%5Bauthor%5D|title=g turecki[Author] - PubMed - NCBI|publisher=ncbi.nlm.nih.gov|accessdate=2014-12-09}} 6. ^{{cite journal | last1 = McGowan | first1 = P | last2 = Sasaki | first2 = A | last3 = D'Alessio | first3 = ACD | last4 = Dymov | first4 = S | last5 = Labonté | first5 = B | last6 = Szyf | first6 = M | last7 = Turecki | first7 = G | last8 = Meaney | first8 = M | year = 2009 | title = Epigenetic regulation of the glucocorticoid receptor in human brain associates with childhood abuse | url = | journal = Nat Neurosci | volume = 12 | issue = 3| pages = 342–8 | doi=10.1038/nn.2270| pmc = 2944040 }} 7. ^{{cite journal | last1 = Labonté | first1 = B | last2 = Suderman | first2 = M | last3 = Maussion | first3 = G | last4 = Navaro | first4 = L | last5 = Yerko | first5 = V | last6 = Mahar | first6 = I | last7 = Bureau | first7 = A | last8 = Mechawar | first8 = N | last9 = Szyf | first9 = M | last10 = Meaney | first10 = MJ | last11 = Turecki | first11 = G | year = 2012 | title = Genome-wide epigenetic regulation by early-life trauma | url = | journal = Arch Gen Psychiatry | volume = 69 | issue = 7| pages = 722–31 | doi=10.1001/archgenpsychiatry.2011.2287| pmc = 4991944 }} 8. ^{{cite journal | last1 = Labonte | first1 = B | last2 = Yerko | first2 = V | last3 = Gross | first3 = J | last4 = Mechawar | first4 = N | last5 = Meaney | first5 = MJ | last6 = Szyf | first6 = M | last7 = Turecki | first7 = G | year = 2012 | title = Differential Glucocorticoid Receptor Exon 1(B), 1(C), and 1(H) Expression and Methylation in Suicide Completers with a History of Childhood Abuse | url = | journal = Biol Psychiatry | volume = 72 | issue = 1| pages = 41–8 | doi=10.1016/j.biopsych.2012.01.034}} 9. ^{{cite journal | last1 = Gross | first1 = JA | last2 = Fiori | first2 = LM | last3 = Labonté | first3 = B | last4 = Lopez | first4 = JP | last5 = Turecki | first5 = G | year = 2013 | title = Effects of promoter methylation on increased expression of polyamine biosynthetic genes in suicide | url = | journal = J Psychiatr Res | volume = 47 | issue = 4| pages = 513–9 | doi = 10.1016/j.jpsychires.2012.11.016 | pmc = 5293536 }} 10. ^{{cite journal | last1 = Lopez | first1 = JP | last2 = Fiori | first2 = LM | last3 = Gross | first3 = JA | last4 = Labonte | first4 = B | last5 = Yerko | first5 = V | last6 = Mechawar | first6 = N | last7 = Turecki | first7 = G | year = 2013 | title = Regulatory role of miRNAs in polyamine gene expression in the prefrontal cortex of depressed suicide completers | url = | journal = Int J Neuropsychopharmacol | volume = 17 | issue = 1| pages = 23–32 | doi = 10.1017/S1461145713000941 }} 11. ^{{cite journal | last1 = Lopez | first1 = JP | last2 = Lim | first2 = R | last3 = Cruceanu | first3 = C | last4 = Crapper | first4 = L | last5 = Fasano | first5 = C | last6 = Labonte | first6 = B | last7 = Maussion | first7 = G | last8 = Yang | first8 = JP | last9 = Yerko | first9 = V | last10 = Vigneault | first10 = E | last11 = El Mestikawy | first11 = S | last12 = Mechawar | first12 = N | last13 = Pavlidis | first13 = P | last14 = Turecki | first14 = G | year = 2014 | title = miR-1202 is a primate-specific and brain-enriched microRNA involved in major depression and antidepressant treatment | journal = Nat Med | volume = 20| issue = | pages = 764–8| doi = 10.1038/nm.3582 | pmid=24908571 | pmc=4087015}} 12. ^{{cite journal | last1 = McGirr | first1 = A | last2 = Renaud | first2 = J | last3 = Bureau | first3 = A | last4 = Seguin | first4 = M | last5 = Lesage | first5 = A | last6 = Turecki | first6 = G | year = 2008 | title = Impulsive-aggressive behaviours and completed suicide across the life cycle: a redisposition for younger age of suicide | url = | journal = Psychol Med | volume = 38 | issue = 3| pages = 407–17 | doi=10.1017/s0033291707001419}} 13. ^http://douglasbrainbank.ca 14. ^http://www.frqs.gouv.qc.ca/fr/financement/resultats/2012-2013/pdf/Chercheurs%20nationaux%202012-13.pdf 15. ^https://www.mcgill.ca/provost/distinguished/wds 16. ^fr:Scientifique de l'année (Société Radio-Canada) 17. ^1 http://ici.radio-canada.ca/emissions/rdi_week_end/2009-2010/Entrevue.asp?idDoc=101300 18. ^http://www.quebecscience.qc.ca/les-10-decouvertes-2009/Une-epine-dans-la-tete 19. ^https://ccnp.ca/Awards/PastWinners 20. ^https://www.afsp.org/research/research-connection/gene-expression-in-the-brain-and-suicide 21. ^http://grahamboeckhfoundation.org/news/dr-turecki-2014-recipient-dr-samarthji-lal-award 22. ^http://www.quebecscience.qc.ca/10-decouvertes-2014/8-Cette-molecule-qui-nous-deprime 23. ^{{Cite web|title = Elkes Past Winners - ACNP|url = http://www.acnp.org/programs/Detail.aspx?cid=0d991154-7a17-4605-aaf9-71a3614f9dc5|website = www.acnp.org|access-date = 2016-02-11}} External links
7 : 1965 births|Living people|Canadian psychiatrists|McGill University faculty|McGill University alumni|Canadian geneticists|Scientists from Montreal |
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