HldE may refer to:

• D-glycero-beta-D-manno-heptose-7-phosphate kinase, an enzyme
• D-glycero-beta-D-manno-heptose 1-phosphate adenylyltransferase, an enzyme

• 3rd Avenue Bridge
• 3rd Avenue Line
• 3rd baron of Offaly
• 3rd base
• 3rd Base
• 3rd Base 4th
• 3rd baseman
• 3rd Baseman
• 3rd Battalion, 10th Marines
• 3rd Battalion, 11th Marines
• 3rd Battalion, 12th Marines
• 3rd Battalion, 14th Marines
• 3rd Battalion 16th Field Artillery
• 3rd Battalion, 1st Marine Regiment
• 3rd Battalion, 1st Marines
• 3rd Battalion, 23rd Marines
• 3rd Battalion, 24th Marines
• 3rd Battalion, 25th Marines
• 3rd Battalion 29th Field Artillery
• 3rd Battalion, 29th Field Artillery Regiment (United States)
• 3rd Battalion, 2nd Marines
• 3rd Battalion, 325th Airborne
• 3rd Battalion, 3rd Marine Regiment
• 3rd Battalion, 3rd Marines
• 3rd Battalion 4th Marine Regiment