| 释义 |
- Function
- References
- Further reading
{{Infobox_gene}}Heterogeneous nuclear ribonucleoprotein L-like is a protein that in humans is encoded by the HNRNPLL gene.[1] Function HNRNPLL is a master regulator of activation-induced alternative splicing in T cells. In particular, it alters splicing of CD45 (PTPRC; MIM 151460), a tyrosine phosphatase essential for T-cell development and activation.[2] References 1. ^{{cite web | title = Entrez Gene: Heterogeneous nuclear ribonucleoprotein L-like | url = https://www.ncbi.nlm.nih.gov/gene/92906 }}
2. ^{{cite journal | vauthors = Oberdoerffer S, Moita LF, Neems D, Freitas RP, Hacohen N, Rao A | title = Regulation of CD45 alternative splicing by heterogeneous ribonucleoprotein, hnRNPLL | journal = Science | volume = 321 | issue = 5889 | pages = 686–91 | date = August 2008 | pmid = 18669861 | doi = 10.1126/science.1157610 | pmc = 2791692 }}
Further reading {{refbegin | 2}}- {{cite journal | vauthors = Lai Y, Song M, Hakala K, Weintraub ST, Shiio Y | title = Proteomic dissection of the von Hippel-Lindau (VHL) interactome | journal = Journal of Proteome Research | volume = 10 | issue = 11 | pages = 5175–82 | date = November 2011 | pmid = 21942715 | pmc = 3208728 | doi = 10.1021/pr200642c }}
- {{cite journal | vauthors = Topp JD, Jackson J, Melton AA, Lynch KW | title = A cell-based screen for splicing regulators identifies hnRNP LL as a distinct signal-induced repressor of CD45 variable exon 4 | journal = RNA | volume = 14 | issue = 10 | pages = 2038–49 | date = October 2008 | pmid = 18719244 | pmc = 2553740 | doi = 10.1261/rna.1212008 }}
- {{cite journal | vauthors = Wu Z, Yates AL, Hoyne GF, Goodnow CC | title = Consequences of increased CD45RA and RC isoforms for TCR signaling and peripheral T cell deficiency resulting from heterogeneous nuclear ribonucleoprotein L-like mutation | journal = Journal of Immunology | volume = 185 | issue = 1 | pages = 231–8 | date = July 2010 | pmid = 20505149 | pmc = | doi = 10.4049/jimmunol.0903625 }}
- {{cite journal | vauthors = Fedorova OA, Moiseeva TN, Nikiforov AA, Tsimokha AS, Livinskaya VA, Hodson M, Bottrill A, Evteeva IN, Ermolayeva JB, Kuznetzova IM, Turoverov KK, Eperon I, Barlev NA | title = Proteomic analysis of the 20S proteasome (PSMA3)-interacting proteins reveals a functional link between the proteasome and mRNA metabolism | journal = Biochemical and Biophysical Research Communications | volume = 416 | issue = 3–4 | pages = 258–65 | date = December 2011 | pmid = 22079093 | pmc = | doi = 10.1016/j.bbrc.2011.10.126 }}
- {{cite journal | vauthors = Shur I, Ben-Avraham D, Benayahu D | title = Alternatively spliced isoforms of a novel stromal RNA regulating factor | journal = Gene | volume = 334 | pages = 113–21 | date = June 2004 | pmid = 15256261 | pmc = | doi = 10.1016/j.gene.2004.03.012 }}
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