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词条 Homospermidine synthase
释义

  1. References

  2. External links

{{Infobox enzyme
| Name = Homospermidine synthase
| EC_number = 2.5.1.44
| CAS_number = 76106-84-8
| IUBMB_EC_number = 2/5/1/44
| GO_code =
| image =
| width =
| caption =
}}Homospermidine synthase ({{EC number|2.5.1.44}}) is an enzyme with systematic name putrescine:putrescine 4-aminobutyltransferase (ammonia-forming).[1][2][3][4][5][6] This enzyme catalyses the following chemical reaction

(1) 2 putrescine sym-homospermidine + NH3 + H+

(2) putrescine + spermidine sym-homospermidine + propane-1,3-diamine

The reaction of this enzyme occurs in three steps.

References

1. ^{{cite journal | vauthors = Tait GH | title = The formation of homospermidine by an enzyme from Rhodopseudomonas viridis [proceedings] | journal = Biochemical Society Transactions | volume = 7 | issue = 1 | pages = 199–201 | date = February 1979 | pmid = 437275 }}
2. ^{{cite journal | title = Biosynthesis of pyrrolizidine alkaloids: putrescine and spermidine are essential substrates of enzymatic homospermidine formation | vauthors = Böttcher F, Ober D, Hartmann T |journal = Can. J. Chem. |year = 1994 |volume = 72 |pages = 80–85 |pmid = | doi = 10.1139/v94-013 }}
3. ^{{cite journal | vauthors = Yamamoto S, Nagata S, Kusaba K | title = Purification and characterization of homospermidine synthase in Acinetobacter tartarogenes ATCC 31105 | journal = Journal of Biochemistry | volume = 114 | issue = 1 | pages = 45–9 | date = July 1993 | pmid = 8407874 }}
4. ^{{cite journal | vauthors = Srivenugopal KS, Adiga PR | title = Enzymic synthesis of sym-homospermidine in Lathyrus sativus (grass pea) seedlings | journal = The Biochemical Journal | volume = 190 | issue = 2 | pages = 461–4 | date = August 1980 | pmid = 7470060 | pmc = 1162113 }}
5. ^{{cite journal | title = Homospermidine synthase of Rhodopseudomonas viridis: Substrate specificity and effects of the heterologously expressed enzyme on polyamine metabolism of Escherichia coli | vauthors = Ober D, Tholl D, Martin W, Hartmann T |journal = J. Gen. Appl. Microbiol. |year = 1996 |volume = 42 |pages = 411–419 |pmid = | doi = 10.2323/jgam.42.411 | issue = 5 }}
6. ^{{cite journal | vauthors = Ober D, Hartmann T | title = Homospermidine synthase, the first pathway-specific enzyme of pyrrolizidine alkaloid biosynthesis, evolved from deoxyhypusine synthase | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 96 | issue = 26 | pages = 14777–82 | date = December 1999 | pmid = 10611289 | pmc = 24724 | doi = 10.1073/pnas.96.26.14777 | bibcode = 1999PNAS...9614777O }}

External links

  • {{MeshName|Homospermidine+synthase}}
{{Alkyl and aryl transferases}}{{Enzymes}}{{Portal bar|Molecular and Cellular Biology|border=no}}

1 : EC 2.5.1

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