“Hop diffusion”的意思、由来-开放百科全书

Hop diffusion - is a non-Brownian diffusion of proteins and lipid molecules within the plasma membrane.

According to the Fences and pickets model, plasma membrane is compartmentalized by actin-based membrane-skeleton “fences”, that occur when cytoplasmic domains collide with the actin-based membrane skeleton; ^[1] and anchored-transmembrane protein “pickets”.^[2] Due to these obstacles membrane proteins undergo temporary confinement within 30–700- nm compartments with infrequent intercompartmental hops.^[3]

While simple Brownian diffusion is isotropic and homogeneous, hop diffusion is more complex and combines free diffusion, which occurs inside cell membrane compartments, and infrequent intercompartmental transitions (hops). The complexity of this type of anomalous diffusion is further enhanced due to an inherent broad distribution of compartment sizes.

References

1. ^{{Cite journal|last=Krapf|first=Diego|date=2018|title=Compartmentalization of the plasma membrane|url=http://linkinghub.elsevier.com/retrieve/pii/S0955067417300893|journal=Current Opinion in Cell Biology|volume=53|pages=15–21|doi=10.1016/j.ceb.2018.04.002|issn=0955-0674|via=}}
2. ^{{cite journal |vauthors=Kusumi A, Nakada C, Ritchie K, etal |title=Paradigm shift of the plasma membrane concept from the two-dimensional continuum fluid to the partitioned fluid: high-speed single-molecule tracking of membrane molecules.| journal=Annu Rev Biophys Biomol Struct |url=http://www.annualreviews.org/doi/abs/10.1146/annurev.biophys.34.040204.144637 |date=February 7, 2005 |volume=34 |pages=351–378 |doi=10.1146/annurev.biophys.34.040204.144637}}
3. ^{{cite journal |vauthors=Ritchie K, Shan XY, Kondo J, etal |title=Detection of non-Brownian diffusion in the cell membrane in single molecule tracking.| journal=Biophys. J. |url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1305276/pdf/2266.pdf/ |date=March 2005 |volume= 88|pages=2266–77 |pmc=1305276 |pmid=15613635 |doi=10.1529/biophysj.104.054106}}