| 词条 | HORMA domain |
| 释义 |
| Symbol = HORMA | Name = HORMA domain | image = PDB 1go4 EBI.jpg | width = | caption = crystal structure of mad1-mad2 reveals a conserved mad2 binding motif in mad1 and cdc20. | Pfam = PF02301 | Pfam_clan = | InterPro = IPR003511 | SMART = | PROSITE = | MEROPS = | SCOP = 1duj | TCDB = | OPM family = | OPM protein = | CAZy = | CDD = }} In molecular biology, the HORMA domain (named after the Hop1p, Rev7p and MAD2 proteins) is a protein domain that has been suggested to recognise chromatin states resulting from DNA adducts, double stranded breaks or non-attachment to the spindle and act as an adaptor that recruits other proteins. Hop1 is a meiosis-specific protein, Rev7 is required for DNA damage induced mutagenesis, and MAD2 is a spindle checkpoint protein which prevents progression of the cell cycle upon detection of a defect in mitotic spindle integrity.[1][2] ExamplesHumans proteins containing this domain include:
References1. ^{{cite journal|vauthors=He X, Patterson TE, Sazer S | title=The Schizosaccharomyces pombe spindle checkpoint protein mad2p blocks anaphase and genetically interacts with the anaphase-promoting complex. | journal=Proc Natl Acad Sci U S A | year= 1997 | volume= 94 | issue= 15 | pages= 7965–70 | pmid=9223296 | doi= 10.1073/pnas.94.15.7965| pmc=21538 | url= }} 2. ^{{cite journal|vauthors=Aravind L, Koonin EV | title=The HORMA domain: a common structural denominator in mitotic checkpoints, chromosome synapsis and DNA repair. | journal=Trends Biochem Sci | year= 1998 | volume= 23 | issue= 8 | pages= 284–6 | pmid=9757827 | doi= 10.1016/S0968-0004(98)01257-2| pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=9757827 }} External links
1 : Protein domains |
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