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词条 HP1BP3
释义

  1. Model organisms

  2. References

  3. Further reading

{{Infobox_gene}}Heterochromatin protein 1, binding protein 3 is a protein that in humans is encoded by the HP1BP3 gene.[1] It has been identified as a novel subtype of the linker histone H1, involved in the structure of heterochromatin [2][3][4]

Model organisms

Model organisms have been used in the study of HP1BP3 function. A conditional knockout mouse line, called Hp1bp3tm1a(EUCOMM)Wtsi[12][13] was generated as part of the International Knockout Mouse Consortium program — a high-throughput mutagenesis project to generate and distribute animal models of disease to interested scientists — at the Wellcome Trust Sanger Institute.[14][15][16] Male and female animals underwent a standardized phenotypic screen to determine the effects of deletion.[10][17] Twenty three tests were carried out and six significant phenotypes were reported. Fewer homozygous mutant embryos were identified during gestation than predicted by Mendelian ratio. Homozygous mutant female adults had decreased body weight, heart weight and bone mineral density, and increased blood urea levels and T cell number.[10]

HP1BP3 deficiency in mice results in severe dwarfism and impaired bone mass, caused by altered endocrine IGF-1 signaling.[18] The gene is highly expressed in the brain and a number of behavioral phenotypes have been described for the mice. Lack of HP1BP3 led to impaired maternal behavior and reduced anxiety, leading to a dramatic reduction in litter survival.[19] This may be related to the connection between HP1BP3 and postpartum depression in humans.[20] Finally, HP1BP3 has been implicated in Alzheimer's disease. .[21]

References

1. ^{{cite web | title = Entrez Gene: heterochromatin protein 1, binding protein 3| url = https://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=retrieve&list_uids=50809| accessdate = 2011-08-30}}
2. ^{{cite journal | vauthors = Garfinkel BP, Melamed-Book N, Anuka E, Bustin M, Orly J | title = HP1BP3 is a novel histone H1 related protein with essential roles in viability and growth | journal = Nucleic Acids Research | volume = 43 | issue = 4 | pages = 2074–90 | date = February 2015 | pmid = 25662603 | pmc = 4344522 | doi = 10.1093/nar/gkv089 }}
3. ^{{cite journal | vauthors = Dutta B, Ren Y, Hao P, Sim KH, Cheow E, Adav S, Tam JP, Sze SK | title = Profiling of the Chromatin-associated Proteome Identifies HP1BP3 as a Novel Regulator of Cell Cycle Progression | journal = Molecular & Cellular Proteomics | volume = 13 | issue = 9 | pages = 2183–97 | date = September 2014 | pmid = 24830416 | pmc = 4159643 | doi = 10.1074/mcp.M113.034975 }}
4. ^{{cite journal | vauthors = Hayashihara K, Uchiyama S, Shimamoto S, Kobayashi S, Tomschik M, Wakamatsu H, No D, Sugahara H, Hori N, Noda M, Ohkubo T, Zlatanova J, Matsunaga S, Fukui K | title = The middle region of an HP1-binding protein, HP1-BP74, associates with linker DNA at the entry/exit site of nucleosomal DNA | journal = The Journal of Biological Chemistry | volume = 285 | issue = 9 | pages = 6498–507 | date = February 2010 | pmid = 20042602 | pmc = 2825445 | doi = 10.1074/jbc.M109.092833 }}
5. ^{{cite web |url=http://www.sanger.ac.uk/mouseportal/phenotyping/MABC/weight-curves/ |title=Body weight data for Hp1bp3 |publisher=Wellcome Trust Sanger Institute}}
6. ^{{cite web |url=http://www.sanger.ac.uk/mouseportal/phenotyping/MABC/body-composition-dexa/ |title=DEXA data for Hp1bp3 |publisher=Wellcome Trust Sanger Institute}}
7. ^{{cite web |url=http://www.sanger.ac.uk/mouseportal/phenotyping/MABC/plasma-chemistry/ |title=Clinical chemistry data for Hp1bp3 |publisher=Wellcome Trust Sanger Institute}}
8. ^{{cite web |url=http://www.sanger.ac.uk/mouseportal/phenotyping/MABC/heart-weight/ |title=Heart weight data for Hp1bp3 |publisher=Wellcome Trust Sanger Institute}}
9. ^{{cite web |url=http://www.sanger.ac.uk/mouseportal/phenotyping/MABC/citrobacter-challenge/ |title=Citrobacter infection data for Hp1bp3 |publisher=Wellcome Trust Sanger Institute}}
10. ^1 2 {{cite journal| doi = 10.1111/j.1755-3768.2010.4142.x| title = The Sanger Mouse Genetics Programme: High throughput characterisation of knockout mice| year = 2010| author = Gerdin AK| journal = Acta Ophthalmologica| volume = 88| issue = S248 }}
11. ^Mouse Resources Portal, Wellcome Trust Sanger Institute.
12. ^{{cite web |url=http://www.knockoutmouse.org/martsearch/search?query=Hp1bp3 |title=International Knockout Mouse Consortium}}
13. ^{{cite web |url=http://www.informatics.jax.org/searchtool/Search.do?query=MGI:4432659 |title=Mouse Genome Informatics}}
14. ^{{cite journal | vauthors = Skarnes WC, Rosen B, West AP, Koutsourakis M, Bushell W, Iyer V, Mujica AO, Thomas M, Harrow J, Cox T, Jackson D, Severin J, Biggs P, Fu J, Nefedov M, de Jong PJ, Stewart AF, Bradley A | title = A conditional knockout resource for the genome-wide study of mouse gene function | journal = Nature | volume = 474 | issue = 7351 | pages = 337–42 | date = June 2011 | pmid = 21677750 | pmc = 3572410 | doi = 10.1038/nature10163 }}
15. ^{{cite journal | vauthors = Dolgin E | title = Mouse library set to be knockout | journal = Nature | volume = 474 | issue = 7351 | pages = 262–3 | date = June 2011 | pmid = 21677718 | doi = 10.1038/474262a }}
16. ^{{cite journal | vauthors = Collins FS, Rossant J, Wurst W | title = A mouse for all reasons | journal = Cell | volume = 128 | issue = 1 | pages = 9–13 | date = January 2007 | pmid = 17218247 | doi = 10.1016/j.cell.2006.12.018 }}
17. ^{{cite journal | vauthors = van der Weyden L, White JK, Adams DJ, Logan DW | title = The mouse genetics toolkit: revealing function and mechanism | journal = Genome Biology | volume = 12 | issue = 6 | pages = 224 | year = 2011 | pmid = 21722353 | pmc = 3218837 | doi = 10.1186/gb-2011-12-6-224 }}
18. ^{{cite journal | vauthors = Garfinkel BP, Arad S, Le PT, Bustin M, Rosen CJ, Gabet Y, Orly J | title = Proportionate Dwarfism in Mice Lacking Heterochromatin Protein 1 Binding Protein 3 (HP1BP3) Is Associated With Alterations in the Endocrine IGF-1 Pathway | journal = Endocrinology | volume = 156 | issue = 12 | pages = 4558–70 | date = December 2015 | pmid = 26402843 | doi = 10.1210/en.2015-1668 }}
19. ^{{cite journal | vauthors = Garfinkel BP, Arad S, Neuner S, Netser S, Wagner S, Kaczorowski CC, Rosen CJ, Gal M, Soreq H, Orly J | title = HP1BP3 expression determines maternal behavior and offspring survival | journal = Genes, Brain, and Behavior | date = July 2016 | pmid = 27470444 | doi = 10.1111/gbb.12312 | volume=15 | pages=678–88}}
20. ^{{cite journal | vauthors = Guintivano J, Arad M, Gould TD, Payne JL, Kaminsky ZA | title = Antenatal prediction of postpartum depression with blood DNA methylation biomarkers | journal = Molecular Psychiatry | volume = 19 | issue = 5 | pages = 560–7 | date = May 2014 | pmid = 23689534 | doi = 10.1038/mp.2013.62 }}
21. ^{{cite journal | vauthors = Neuner SM, Garfinkel BP, Wilmott LA, Ignatowska-Jankowska BM, Citri A, Orly J, Lu L, Overall RW, Mulligan MK, Kempermann G, Williams RW, O'Connell KM, Kaczorowski CC | title = Systems genetics identifies Hp1bp3 as a novel modulator of cognitive aging | journal = Neurobiology of Aging | volume = 46 | pages = 58–67 | date = June 2016 | pmid = 27460150 | doi = 10.1016/j.neurobiolaging.2016.06.008 }}

Further reading

  • {{cite journal | vauthors = Rose JE, Behm FM, Drgon T, Johnson C, Uhl GR | title = Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score | journal = Molecular Medicine | volume = 16 | issue = 7-8 | pages = 247–53 | pmid = 20379614 | pmc = 2896464 | doi = 10.2119/molmed.2009.00159 }}
  • {{cite journal | vauthors = Ouyang J, Shi Y, Valin A, Xuan Y, Gill G | title = Direct binding of CoREST1 to SUMO-2/3 contributes to gene-specific repression by the LSD1/CoREST1/HDAC complex | journal = Molecular Cell | volume = 34 | issue = 2 | pages = 145–54 | date = April 2009 | pmid = 19394292 | pmc = 2727917 | doi = 10.1016/j.molcel.2009.03.013 }}
  • {{cite journal | vauthors = Martins-de-Souza D, Gattaz WF, Schmitt A, Rewerts C, Maccarrone G, Dias-Neto E, Turck CW | title = Prefrontal cortex shotgun proteome analysis reveals altered calcium homeostasis and immune system imbalance in schizophrenia | journal = European Archives of Psychiatry and Clinical Neuroscience | volume = 259 | issue = 3 | pages = 151–63 | date = April 2009 | pmid = 19165527 | doi = 10.1007/s00406-008-0847-2 }}
  • {{cite journal | vauthors = Flachsbart F, Franke A, Kleindorp R, Caliebe A, Blanché H, Schreiber S, Nebel A | title = Investigation of genetic susceptibility factors for human longevity - a targeted nonsynonymous SNP study | journal = Mutation Research | volume = 694 | issue = 1-2 | pages = 13–9 | date = December 2010 | pmid = 20800603 | doi = 10.1016/j.mrfmmm.2010.08.006 }}
  • {{cite journal | vauthors = Hayashihara K, Uchiyama S, Shimamoto S, Kobayashi S, Tomschik M, Wakamatsu H, No D, Sugahara H, Hori N, Noda M, Ohkubo T, Zlatanova J, Matsunaga S, Fukui K | title = The middle region of an HP1-binding protein, HP1-BP74, associates with linker DNA at the entry/exit site of nucleosomal DNA | journal = The Journal of Biological Chemistry | volume = 285 | issue = 9 | pages = 6498–507 | date = February 2010 | pmid = 20042602 | pmc = 2825445 | doi = 10.1074/jbc.M109.092833 }}
  • {{cite journal | vauthors = Gautier VW, Gu L, O'Donoghue N, Pennington S, Sheehy N, Hall WW | title = In vitro nuclear interactome of the HIV-1 Tat protein | journal = Retrovirology | volume = 6 | issue = | pages = 47 | year = 2009 | pmid = 19454010 | pmc = 2702331 | doi = 10.1186/1742-4690-6-47 }}
{{refend}}

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