1. Function

2. Structure

3. References

In molecular biology, YccV protein domain is also, alternatively named, Heat shock protein HspQ. This entry describes the small protein from Escherichia coli YccV and its homologs in other Proteobacteria. YccV is now described as a hemimethylated DNA binding protein.^[1] The model entry describes a protein domain in longer eukaryotic proteins.

Function

HspQ is involved in the degradation of certain denaturated proteins, including DnaA, during Heat shock stress.^[2] HspQ (YccV like protein domain) is a hemimethylated DNA-binding protein. It has been thought to negatively regulate dnaA gene expression when its promoter region is either methylated or hemimethylated. This could occurs through binding of YccV itself to fully or hemimethylated DNA.^[1] In addition, studies have identified the yccV gene as one of three insertion sites in mini-Tn10 which suppress dnaA46 thermosensitivity.

Structure

This protein domain is thought to have a SH3-like barrel structure. Additionally, the structure of a hypothetical protein in this family has been solved and it forms a beta sheet structure with a terminating alpha helix. HspQ forms a stable homodimer in solution and can form homomultimers consisting of about four monomers. The theoretical molecular mass of the HspQ protein were calculated to be 11.8 kDa. It is putatively thought that HspQ requires a cofactor to form a functional hetero-oligomeric complex.^[2]

References

• Hugh de cressingham
• Hugh de Cyfeiliog, 3rd Earl of Chester
• Hugh de giffard
• Hugh de grandmesnil
• Hugh dei Lippi Uggucioni
• Hugh de Kevelioc, 3rd Earl of Chester
• Hugh de Laci
• Hugh de lacy
• Hugh de Lacy, 5th Baron Lacy
• Hugh de Largie
• Hugh de mapenor
• Hugh de mortimer
• Hugh de Morvile
• Hugh de morvile
• Hugh de Morville
• Hugh de Morville (disambiguation)
• Hugh Dempsey
• Hugh Dempster
• Hugh Denis Macrossan
• Hugh de Nonant
• Hugh Denys
• Hugh Denys, Groom of the Stool
• Hugh Denys of Osterley
• Hugh de Orivalle
• Hugh de Paduinan