| 词条 | Human endogenous retrovirus K |
| 释义 |
| image = | image_alt = | image_caption = | taxon = Human endogenous retrovirus K | authority = | synonyms = | synonyms_ref = | subdivision_ranks = | subdivision = }} Human endogenous retrovirus K (HERV-K) or Human teratocarcinoma-derived virus (HDTV) is a family of human endogenous retroviruses associated with malignant tumors of the testes.[1][2][3][4] HERV-K is also found in apes and Old World monkeys. In 1999 Barbulescu, et al. showed that, of ten HERV-K proviruses cloned, eight were unique to humans, while one was shared with chimpanzees and bonobos, and one with chimpanzees, bonobos and gorillas.[5] In 2015 Grow et al. demonstrated that HERV-K is transcribed during embryogenesis from the eight cell stage up to the stem cell derivation.[6] Furthermore, overexpression of the HERV-K accessory protein Rec increases IFITM1 levels on the cell surface and inhibits viral infection.[6][7] See also
References1. ^{{Cite book|author=Boeke JD, Stoye JP|title=Retrotransposons, endogenous retroviruses, and the evolution of retroelements|work=Retroviruses|editor1=JM Coffin|editor2=SH Hughes |editor3=HE Varmus |location=Cold Spring Harbor, New York |publisher=Cold Spring Harbor Laboratory Press |date=1997|pages=343–435}} 2. ^{{cite journal|last1=Boller|first1=Klaus|last2=König|first2=Herbert|last3=Sauter|first3=Marlies|last4=Mueller-Lantzsch|first4=Nikolaus|last5=Löwer|first5=Roswitha|last6=Löwer|first6=Johannes|last7=Kurth|first7=Reinhard|title=Evidence That HERV-K Is the Endogenous Retrovirus Sequence That Codes for the Human Teratocarcinoma-Derived Retrovirus HTDV|journal=Virology|date=September 1993|volume=196|issue=1|pages=349–353|doi=10.1006/viro.1993.1487 |pmid=8356806}} 3. ^{{cite journal|last1=Löwer|first1=J|last2=Wondrak|first2=EM|last3=Kurth|first3=R|title=Genome analysis and reverse transcriptase activity of human teratocarcinoma-derived retroviruses.|journal=The Journal of General Virology|date=November 1987|volume=68|pages=2807–15|pmid=2445905|issue=11|doi=10.1099/0022-1317-68-11-2807}} 4. ^{{cite book|last1=Rédei|first1=George P.|title=Encyclopedia of genetics, genomics, proteomics, and informatics|date=2008|publisher=Springer| isbn=978-1-4020-6754-9|edition=3rd}} 5. ^{{Cite journal |author1=Madalina Barbulescu |author2=Geoffrey Turner |author3=Michael I. Seaman† |author4=Amos S. Deinard‡§ |author5=Kenneth K. Kidd |author6=Jack Lenz |title=Many human endogenous retrovirus K (HERV-K) proviruses are unique to humans |journal=Current Biology |date=1999 |volume=9 |issue=16 |doi=10.1016/s0960-9822(99)80390-x |pages=861–8 |url=http://tools.medicine.yale.edu/kidd/www/377.pdf |pmid=10469592 |deadurl=yes |archiveurl=https://web.archive.org/web/20130228083443/http://tools.medicine.yale.edu/kidd/www/377.pdf |archivedate=28 February 2013 |df=dmy-all |bibcode=1996CBio....6.1213A }} 6. ^1 {{Cite journal |title=Intrinsic retroviral reactivation in human preimplantation embryos and pluripotent cells |author1=Edward J. Grow |author2=Ryan A. Flynn |author3=Shawn L. Chavez |author4=Nicholas L. Bayless |author5=Mark Wossidlo |author6=Daniel J. Wesche |author7=Lance Martin |author8=Carol B. Ware |author9=Catherine A. Blish |author10=Howard Y. Chang|authorlink10=Howard Y. Chang |author11=Renee A. Reijo Pera |author12=Joanna Wysocka |journal=Nature |volume=522 |issue=7555 |pages=221–5 |date=11 June 2015 |doi=10.1038/nature14308 |pmid=25896322 |pmc=4503379|bibcode=2015Natur.522..221G }} 7. ^{{cite journal|vauthors=Hanke K, Hohn O, Bannert N |title=HERV-K(HML-2), a seemingly silent subtenant – but still waters run deep |journal=APMIS |date=January–February 2016 |volume=124 |issue=1–2 |pages=67–87 |pmid=26818263 |doi=10.1111/apm.12475}} For Further Info
1 : Endogenous retroviruses |
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