| 词条 | Human maximisation test |
| 释义 |
The Human maximisation test (HMT) is a test method for testing for contact allergens. It was first developed by Albert Kligman in 1966[1] and updated by Kligman and William Epstein in 1975.[2] The first paper appeared 1966[3] and was a citation classic in 1985.[4] The test uses human medical volunteers (usually 25) and sodium laureth sulphate to maximise. Because of the potentially large human reaction, it is generally not considered ethical to use today.[5] It does not have a guideline under the OECD Guidelines for the Testing of Chemicals. It has been compared with the murine local lymph node assay[6][7] See also patch test. References1. ^The Identification of Contact Allergens by Human Assay III. The Maximization Test: A Procedure for Screening and Rating Contact Sensitizers http://www.nature.com/jid/journal/v47/n5/abs/jid1966160a.html 2. ^{{cite journal | last1 = Kligman | first1 = A. M. | last2 = Epstein | first2 = W. | year = 1975 | title = Updating the maximization test for identifying contact allergens | url = | journal = Contact Dermatitis | volume = 1 | issue = 4| pages = 231–239 | doi = 10.1111/j.1600-0536.1975.tb05389.x }} 3. ^{{cite journal | last1 = Kligman | first1 = A. M. | year = 1966 | title = The identification of contact allergens by human assay. III. The maximization test: a procedure for screening and rating contact sensitizers | url = | journal = J. Invest. Dermatol. | volume = 47 | issue = 5| pages = 393–409 | pmid = 5924294 | doi = 10.1038/jid.1966.160 }} 4. ^http://garfield.library.upenn.edu/classics1985/A1985AUG6800001.pdf 5. ^http://ec.europa.eu/health/scientific_committees/consumer_safety/opinions/sccnfp_opinions_97_04/sccp_out102_en.htm 6. ^DA Basketter, EW Scholes, I Kimber (1994). The performance of the local lymph node assay with chemicals identified as contact allergens in the human maximization test. Food and Chemical Toxicology, 1994 - Elsevier 7. ^{{cite journal |pmid=19514928 | doi=10.1080/15569520902793627 | volume=28 | issue=2 | title=The local lymph node assay compared with the human maximization test as an indicator of allergic potency in humans using patch test clinic populations | year=2009 | journal=Cutan Ocul Toxicol | pages=61–4 | last1 = Zaghi | first1 = D | last2 = Maibach | first2 = HI}} 1 : Allergology |
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