- References
- External links
| Name = Hypoxia-inducible factor-asparagine dioxygenase
| EC_number = 1.14.11.30
| CAS_number =
| IUBMB_EC_number = 1/14/11/30
| GO_code =
| image =
| width =
| caption =
}}Hypoxia-inducible factor-asparagine dioxygenase ({{EC number|1.14.11.30}}, HIF hydroxylase) is an enzyme with systematic name hypoxia-inducible factor-L-asparagine, 2-oxoglutarate:oxygen oxidoreductase (4-hydroxylating).[1][2][3][4][5][6] This enzyme catalyses the following chemical reaction
hypoxia-inducible factor-L-asparagine + 2-oxoglutarate + O2hypoxia-inducible factor-(3S)-3-hydroxy-L-asparagine + succinate + CO2
Hypoxia-inducible factor-asparagine dioxygenase contains iron, and requires ascorbate.
References
1. ^{{cite journal | vauthors = Mahon PC, Hirota K, Semenza GL | title = FIH-1: a novel protein that interacts with HIF-1alpha and VHL to mediate repression of HIF-1 transcriptional activity | journal = Genes & Development | volume = 15 | issue = 20 | pages = 2675–86 | date = October 2001 | pmid = 11641274 | pmc = 312814 | doi = 10.1101/gad.924501 }}
2. ^{{cite journal | vauthors = Hewitson KS, McNeill LA, Riordan MV, Tian YM, Bullock AN, Welford RW, Elkins JM, Oldham NJ, Bhattacharya S, Gleadle JM, Ratcliffe PJ, Pugh CW, Schofield CJ | title = Hypoxia-inducible factor (HIF) asparagine hydroxylase is identical to factor inhibiting HIF (FIH) and is related to the cupin structural family | journal = The Journal of Biological Chemistry | volume = 277 | issue = 29 | pages = 26351–5 | date = July 2002 | pmid = 12042299 | doi = 10.1074/jbc.C200273200 | authorlink13 = Christopher J. Schofield }}
3. ^{{cite journal | vauthors = Dann CE, Bruick RK, Deisenhofer J | title = Structure of factor-inhibiting hypoxia-inducible factor 1: An asparaginyl hydroxylase involved in the hypoxic response pathway | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 99 | issue = 24 | pages = 15351–6 | date = November 2002 | pmid = 12432100 | pmc = 137720 | doi = 10.1073/pnas.202614999 | bibcode = 2002PNAS...9915351D }}
4. ^{{cite journal | vauthors = Lando D, Peet DJ, Whelan DA, Gorman JJ, Whitelaw ML | title = Asparagine hydroxylation of the HIF transactivation domain a hypoxic switch | journal = Science | volume = 295 | issue = 5556 | pages = 858–61 | date = February 2002 | pmid = 11823643 | doi = 10.1126/science.1068592 | bibcode = 2002Sci...295..858L }}
5. ^{{cite journal | vauthors = Koivunen P, Hirsilä M, Günzler V, Kivirikko KI, Myllyharju J | title = Catalytic properties of the asparaginyl hydroxylase (FIH) in the oxygen sensing pathway are distinct from those of its prolyl 4-hydroxylases | journal = The Journal of Biological Chemistry | volume = 279 | issue = 11 | pages = 9899–904 | date = March 2004 | pmid = 14701857 | doi = 10.1074/jbc.M312254200 }}
6. ^{{cite journal | vauthors = Elkins JM, Hewitson KS, McNeill LA, Seibel JF, Schlemminger I, Pugh CW, Ratcliffe PJ, Schofield CJ | title = Structure of factor-inhibiting hypoxia-inducible factor (HIF) reveals mechanism of oxidative modification of HIF-1 alpha | journal = The Journal of Biological Chemistry | volume = 278 | issue = 3 | pages = 1802–6 | date = January 2003 | pmid = 12446723 | doi = 10.1074/jbc.C200644200 }}
2. ^{{cite journal | vauthors = Hewitson KS, McNeill LA, Riordan MV, Tian YM, Bullock AN, Welford RW, Elkins JM, Oldham NJ, Bhattacharya S, Gleadle JM, Ratcliffe PJ, Pugh CW, Schofield CJ | title = Hypoxia-inducible factor (HIF) asparagine hydroxylase is identical to factor inhibiting HIF (FIH) and is related to the cupin structural family | journal = The Journal of Biological Chemistry | volume = 277 | issue = 29 | pages = 26351–5 | date = July 2002 | pmid = 12042299 | doi = 10.1074/jbc.C200273200 | authorlink13 = Christopher J. Schofield }}
3. ^{{cite journal | vauthors = Dann CE, Bruick RK, Deisenhofer J | title = Structure of factor-inhibiting hypoxia-inducible factor 1: An asparaginyl hydroxylase involved in the hypoxic response pathway | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 99 | issue = 24 | pages = 15351–6 | date = November 2002 | pmid = 12432100 | pmc = 137720 | doi = 10.1073/pnas.202614999 | bibcode = 2002PNAS...9915351D }}
4. ^{{cite journal | vauthors = Lando D, Peet DJ, Whelan DA, Gorman JJ, Whitelaw ML | title = Asparagine hydroxylation of the HIF transactivation domain a hypoxic switch | journal = Science | volume = 295 | issue = 5556 | pages = 858–61 | date = February 2002 | pmid = 11823643 | doi = 10.1126/science.1068592 | bibcode = 2002Sci...295..858L }}
5. ^{{cite journal | vauthors = Koivunen P, Hirsilä M, Günzler V, Kivirikko KI, Myllyharju J | title = Catalytic properties of the asparaginyl hydroxylase (FIH) in the oxygen sensing pathway are distinct from those of its prolyl 4-hydroxylases | journal = The Journal of Biological Chemistry | volume = 279 | issue = 11 | pages = 9899–904 | date = March 2004 | pmid = 14701857 | doi = 10.1074/jbc.M312254200 }}
6. ^{{cite journal | vauthors = Elkins JM, Hewitson KS, McNeill LA, Seibel JF, Schlemminger I, Pugh CW, Ratcliffe PJ, Schofield CJ | title = Structure of factor-inhibiting hypoxia-inducible factor (HIF) reveals mechanism of oxidative modification of HIF-1 alpha | journal = The Journal of Biological Chemistry | volume = 278 | issue = 3 | pages = 1802–6 | date = January 2003 | pmid = 12446723 | doi = 10.1074/jbc.C200644200 }}
External links
- {{MeshName|Hypoxia-inducible+factor-asparagine+dioxygenase}}
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