词条 | Inositol-hexakisphosphate kinase |
释义 |
| Name = Inositol-hexakisphosphate kinase | EC_number = 2.7.4.21 | CAS_number = 176898-37-6 | IUBMB_EC_number = 2/7/4/21 | GO_code = | image = | width = | caption = }}Inositol-hexakisphosphate kinase ({{EC number|2.7.4.21}}, ATP:1D-myo-inositol-hexakisphosphate phosphotransferase) is an enzyme with systematic name ATP:1D-myo-inositol-hexakisphosphate 5-phosphotransferase.[1][2][3] This enzyme catalyses the following chemical reaction (1) ATP + 1D-myo-inositol hexakisphosphate ADP + 1D-myo-inositol 5-diphosphate 1,2,3,4,6-pentakisphosphate (2) ATP + 1D-myo-inositol 1,3,4,5,6-pentakisphosphate ADP + 1D-myo-inositol diphosphate tetrakisphosphate (isomeric configuration unknown) Three mammalian isoforms are known to exist. See also
References1. ^{{cite journal | vauthors = Saiardi A, Erdjument-Bromage H, Snowman AM, Tempst P, Snyder SH | title = Synthesis of diphosphoinositol pentakisphosphate by a newly identified family of higher inositol polyphosphate kinases | journal = Current Biology | volume = 9 | issue = 22 | pages = 1323–6 | date = November 1999 | pmid = 10574768 | doi = 10.1016/S0960-9822(00)80055-X }} 2. ^{{cite journal | vauthors = Schell MJ, Letcher AJ, Brearley CA, Biber J, Murer H, Irvine RF | title = PiUS (Pi uptake stimulator) is an inositol hexakisphosphate kinase | journal = FEBS Letters | volume = 461 | issue = 3 | pages = 169–72 | date = November 1999 | pmid = 10567691 | doi = 10.1016/S0014-5793(99)01462-3 }} 3. ^{{cite journal | vauthors = Albert C, Safrany ST, Bembenek ME, Reddy KM, Reddy K, Falck J, Bröcker M, Shears SB, Mayr GW | title = Biological variability in the structures of diphosphoinositol polyphosphates in Dictyostelium discoideum and mammalian cells | journal = The Biochemical Journal | volume = 327 ( Pt 2) | pages = 553–60 | date = October 1997 | pmid = 9359429 | pmc = 1218829 }} External links
1 : EC 2.7.4 |
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