| 词条 | Intermediate cleaving peptidase 55 |
| 释义 |
| Name = Intermediate cleaving peptidase 55 | EC_number = 3.4.11.26 | CAS_number = | IUBMB_EC_number = 3/4/11/26 | GO_code = | image = | width = | caption = }}Intermediate cleaving peptidase 55 ({{EC number|3.4.11.26}}, Icp55, mitochondrial intermediate cleaving peptidase 55 kDa) is an enzyme.[1][2] This enzyme catalyses the following chemical reaction The enzyme cleaves the Pro36-Pro37 bond of cysteine desulfurase (EC 2.8.1.7) removing three amino acid residues (Tyr-Ser-Pro) from the N-terminus after cleavage by mitochondrial processing peptidase. Icp55 removes the destabilizing N-terminal amino acid residues. References1. ^{{cite journal | title = Dual targeting of Nfs1 and discovery of its novel processing enzyme, Icp55 |author1 = Naamati, A. |author2 =Regev-Rudzki, N. |author3 =Galperin, S. |author4 =Lill, R. |author5 =Pines, O. |journal = J. Biol. Chem. |year = 2009 |volume = 284 |pages = 30200–30208 |pmid = 19720832 |doi=10.1074/jbc.M109.034694 |pmc=2781575}} 2. ^{{cite journal | title = Global analysis of the mitochondrial N-proteome identifies a processing peptidase critical for protein stability |author1 = Vogtle, F.N. |author2 =Wortelkamp, S. |author3 =Zahedi, R.P. |author4 =Becker, D. |author5 =Leidhold, C. |author6 =Gevaert, K. |author7 =Kellermann, J. |author8 =Voos, W. |author9 =Sickmann, A. |author10 =Pfanner, N. |author11 =Meisinger, C. | journal = Cell |year = 2009 |volume = 139 |pages = 428–439 |pmid = 19837041 |doi=10.1016/j.cell.2009.07.045}} External links
1 : EC 3.4.11 |
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