Isakovo may refer to:

• Isakovo, Russia, name of several rural localities in Russia
• Isakovo, Serbia, a village in the municipality of Ćuprija, Serbia

• CALB2 (gene)
• Cal Baptist
• Cal Baptist Lancers
• Cal Batlle
• Cal bears men's basketball
• Calbe (crater)
• Cal Beisner
• Calberlah railway station
• Calbha Mor
• Calbha Mòr
• C. albidosimilis
• Calblock overdose
• Calblock poisoning
• Calblock toxicity
• Calboni M'Bani
• C. albonotata
• Calbor
• Calbo (rapper)
• Cal Bouchard
• Calbreath
• Cal Bricker
• Calbuco Department, Chiloe
• Calbuco River
• Calbuco River (disambiguation)
• Calbulco