- References
- External links
| Name = Isoflavonoid synthase
| EC_number = 1.14.13.136
| CAS_number =
| IUBMB_EC_number = 1/14/13/136
| GO_code =
| image =
| width =
| caption =
}}
2-hydroxyisoflavanone synthase ({{EC number|1.14.13.136}}, CYT93C, IFS, isoflavonoid synthase) is an enzyme with systematic name liquiritigenin,NADPH:oxygen oxidoreductase (hydroxylating, aryl migration).[1][2][3] This enzyme catalyses the following chemical reactions:
liquiritigenin + O2 + NADPH + H+2,4',7-trihydroxyisoflavanone + H2O + NADP+
and
(2S)-naringenin + O2 + NADPH + H+
Isoflavonoid synthase requires cytochrome P450.
References
1. ^{{cite journal | vauthors = Hashim MF, Hakamatsuka T, Ebizuka Y, Sankawa U | title = Reaction mechanism of oxidative rearrangement of flavanone in isoflavone biosynthesis | journal = FEBS Letters | volume = 271 | issue = 1–2 | pages = 219–22 | date = October 1990 | pmid = 2226805 | doi = 10.1016/0014-5793(90)80410-k }}
2. ^{{cite journal | vauthors = Sawada Y, Kinoshita K, Akashi T, Aoki T, Ayabe S | title = Key amino acid residues required for aryl migration catalysed by the cytochrome P450 2-hydroxyisoflavanone synthase | journal = The Plant Journal | volume = 31 | issue = 5 | pages = 555–64 | date = September 2002 | pmid = 12207646 | doi = 10.1046/j.1365-313x.2002.01378.x }}
3. ^{{cite journal | vauthors = Sawada Y, Ayabe S | title = Multiple mutagenesis of P450 isoflavonoid synthase reveals a key active-site residue | journal = Biochemical and Biophysical Research Communications | volume = 330 | issue = 3 | pages = 907–13 | date = May 2005 | pmid = 15809082 | doi = 10.1016/j.bbrc.2005.03.053 }}
2. ^{{cite journal | vauthors = Sawada Y, Kinoshita K, Akashi T, Aoki T, Ayabe S | title = Key amino acid residues required for aryl migration catalysed by the cytochrome P450 2-hydroxyisoflavanone synthase | journal = The Plant Journal | volume = 31 | issue = 5 | pages = 555–64 | date = September 2002 | pmid = 12207646 | doi = 10.1046/j.1365-313x.2002.01378.x }}
3. ^{{cite journal | vauthors = Sawada Y, Ayabe S | title = Multiple mutagenesis of P450 isoflavonoid synthase reveals a key active-site residue | journal = Biochemical and Biophysical Research Communications | volume = 330 | issue = 3 | pages = 907–13 | date = May 2005 | pmid = 15809082 | doi = 10.1016/j.bbrc.2005.03.053 }}
External links
- {{MeshName|Isoflavonoid+synthase}}
1 : EC 1.14.13
- Nazhari Kingdom of Granada
- Nazhat Shameem
- NAZI
- Nazia and Zoheb
- Nazi Abad
- Nazi Accession Question
- Nazi Agent
- Nazia Hassan
- Nazia Hassan Foundation
- Nazia Iqbal
- Nazi Anti-Flag Desecration Law
- Nazianus
- Nazianzos
- Nazianzus
- Nazi archaeologist
- Nazi Archaeology
- Nazi archaeology
- Nazi army
- Nazi Atomic Bomb
- Naziba
- Nazi bashing
- Nazi belt buckle pistol
- Nazi birthing centres for foreign workers
- Nazi book burnings
- Nazi boycott of Jewish businesses