James Little may refer to:

• James Little (Unionist politician) (1868–1946), unionist politician in Northern Ireland
• James Little (US politician), Wisconsin State Assemblyman
• James D. Little, U.S. Assistant Secretary of the Navy
• James Little (physician) (1837–1916), Irish physician
• James-Little Ecological Reserve
• Jimmy Little (born 1937), Australian Aboriginal musician, singer and songwriter
• Jimmy Little (carpenter) (born 1976), carpenter, stagehand and TV personality
• James Little (shepherd) (1834–1921), New Zealand shepherd and sheep breeder

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