James Shepherd may refer to:

• James Shepherd (rugby league), former Australian rugby league player
• James Shepherd (Australian cricketer) (1857–?), Australian cricketer
• James Shepherd (New Zealand cricketer) (1892–1970), New Zealand cricketer
• James E. Shepherd (1847–1910), lawyer and jurist who served on the North Carolina Supreme Court
• James Shepherd (biochemist) (born 1944),pioneer in the investigation of the causes, prevention and treatment of coronary heart disease
• James Shepherd (missionary) (1796–1882), Australian-born Wesleyan Christian missionary and settler in New Zealand
• James Shepherd (doctor) (1847–1926), physician and missionary

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