Safford may refer to :

• Safford, Arizona
• Safford, Alabama, an unincorporated community in Dallas County, Alabama
• Safford House, a historic home in Tarpon Springs, Florida
• Safford Cape (1906–1973), American composer and musicologist
• Andrew Safford House, 1819, designed in the Federal style by an unknown architect
• Anson P.K. Safford (1830–1891), 3rd Governor of Arizona Territory (1869–1877)
• Laurance Safford (1890–1973), a U.S. Navy cryptologist
• Truman Henry Safford (1836–1901), an American calculating prodigy
• William Edwin Safford (1859–1926), an American botanist and ethnologist
• Benton Safford, a fictional character in novels by R. B. Dominic
• James M. Safford (1822–1907), an American geologist

and also :

• Katherine Safford Harris, a noted psychologist and speech scientist
• George Safford Parker (1863–1937), an American inventor and industrialist

• Cape Pivnichnyi Odeskyi
• Cape Porcupine, Newfoundland
• Cape Portland Tasmanian
• Cape Portland Tasmanian language
• Cape primrose
• Cape province
• Cape Public Schools
• Cape rain-daisy
• Cape Rain-daisy
• Caperal
• Cape Range grevillea
• Cape Range mallee
• Cape Range stone gecko
• Capercally
• Caper Cat
• Caper Chase
• Caper Clowns
• Cape Rebel
• Cape reed snake
• Caper gull
• Cape rhinoceros
• Cape rice grass
• Cape Riche Homestead
• Caper-leaf webworm
• Caper-leaf webworm moth