Safi may refer to:

• Ghor as-Safi or simply as-Safi, town in Jordan near the south end of the Dead Sea and at the mouth of Wadi Hasa

• Safi, Morocco
• Safi, Malta, a local council on Malta
• Safi Subdivision, Mohmand District, Khyber Pakhtunkhwa, Pakistan
• Safi (given name), an Arabic name
• Safi of Persia, a Safavid Shah of Iran
• Safi (Pashtun tribe)
• Omid Safi, an Iranian-American writer
• Safi Airways, an Afghan Airline based in Dubai
• Safi (medicine), an Unani herbal medicine
• Pasta Zara-Cogeas, an UCI women's cycling team. Formerly named:
  • Safi
  • Safi-Pasta Zara Manhattan
  • Safi-Pasta Zara Titanedi
  • Safi-Pasta Zara
• Safi (rabbitfish), a type of fish found in the Persian Gulf
• {{SS|Safi}}, a German cargo ship in service 1956-60

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