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词条 Joan Massagué
释义

  1. Education and career

  2. Scientific contributions

  3. Awards and honors

  4. References

{{Infobox scientist
| name = Joan Massagué
| image = File:Joan Massagué in suit.jpg
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| birth_date = {{Birth date|1953|04|30}}
| birth_place = Barcelona, Spain
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| fields = cancer biology
| workplaces = Memorial Sloan-Kettering Cancer Center, Institute for Research in Biomedicine
| alma_mater = University of Barcelona, Brown University | thesis_title =
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| known_for = cancer metastasis
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| spouse = }}Joan Massagué (born April 30, 1953 in Barcelona), is a pharmacist and the current director of the Sloan Kettering Institute at Memorial Sloan Kettering Cancer Center. He is also an internationally recognized leader in the study of both cancer metastasis and growth factors that regulate cell behavior, as well as a professor at the Weill Cornell Graduate School of Medical Sciences.[1]

Education and career

Born in Barcelona, Spain, on April 30, 1953, Massagué earned his doctorate degree in biochemistry at the University of Barcelona in 1978 under the mentorship of Professor Joan J. Guinovart.{{citation needed|date=March 2018}} He completed a postdoctoral fellowship in 1982 in the laboratory of Michael P. Czech, PhD, at Brown University, where he determined the composition of the receptor for the hormone insulin. Later that year, he became an assistant professor in biochemistry at the University of Massachusetts Medical School in Worcester.[2]

Massagué joined Memorial Sloan Kettering in 1989 as the Alfred P. Sloan Chair of the Sloan Kettering Institute’s Cell Biology Program and was named founding Chair of the Cancer Biology and Genetics Program in 2003.[2] Additionally, he has served as a Scientific Advisor at the Institute for Research in Biomedicine in Barcelona since 2005.[3]

He was an investigator at the Howard Hughes Medical Institute from 1990 to 2013.[4] In 2014, he joined HHMI’s Scientific Review Board.[5] In 2013, Massagué was named Director of the Sloan Kettering Institute.[6]

Scientific contributions

Massagué is credited with establishing the dual role of TGFβ, which can both inhibit and activate tumor cell growth, and identifying its importance in cancer.[4] His work identified the TGF-β receptors and cell signaling pathway, and defined the central concept of how this pathway controls cell fate.[7]

In 2003, Dr. Massagué and colleagues documented the effects of the gain or loss of the TGF-β pathway in a mouse model of breast cancer, showing that it can increase lung metastases but suppress the growth of primary tumors.[8] That same year, he published another paper that found that two genes expressed in breast cancer were increased in the presence of TGF-β and enabled the tumor cells to metastasize to the bone.[9]

In 2005, Dr. Massagué and his team published a study that identified which breast cancer cells expressing an identified set of genes associated with metastasis were destined to spread to the lung versus elsewhere.[10] Later work characterized gene sets and pathways in human cancer cells that enable breast and lung tumor cells to invade and colonize the brain.[11][12]

Since 2009, his lab has published research on tumor self-seeding by circulating cancer cells, a process by which disseminated metastatic cells that resist cancer therapy re-infiltrate tissues to expand as highly aggressive clones.[13] His lab also found that disseminated cancer cells use the cell adhesion molecule L1CAM to coopt blood capillaries for the initiation of metastatic outgrowth.[14] In 2016, Massagué and his group defined the basis for metastatic latency in breast and lung cancers, and the interplay of metastatic stem cells with the innate immune system.[15]

Awards and honors

  • Pezcoller Foundation-AACR International Award for Cancer Research (2016)[16]
  • Fellow, American Association for Cancer Research (AACR) Academy (2016)[17]
  • Charles Rodolphe Brupbacher Prize for Cancer Research (2015)[18]
  • Robert J. and Claire Pasarow Foundation Medical Research Award (2011)[19]
  • BBVA Frontiers of Knowledge Award in Science and technology (2008)[20]
  • Passano Laureate Award (2007)[21]
  • Vilcek Prize in Biomedical Science(2006)[22]
  • Member, National Academy of Medicine (2006)[23]
  • Prince of Asturias Award in Science and Technology (2004)[24]
  • Member, National Academy of Sciences (2000)[25]
  • Member, American Academy of Arts and Sciences (1999)[26]

References

1. ^{{cite web|title=Joan Massague {{!}} Graduate School of Medical Sciences|url=http://gradschool.weill.cornell.edu/faculty/joan-massague|website=gradschool.weill.cornell.edu|accessdate=31 August 2017|language=en}}
2. ^1 {{cite news|last1=Gittelson|first1=Celia|title=Cancer Biologist Joan Massagué Named Director of the Sloan Kettering Institute|url=https://www.mskcc.org/blog/cancer-biologist-joan-massague-named-director-sloan-kettering-institute|accessdate=31 August 2017|work=www.mskcc.org|date=25 Nov 2013|language=en}}
3. ^{{cite web|title=Joan Massagué joins IRB Barcelona|url=https://www.irbbarcelona.org/en/news/joan-massague-joins-irb-barcelona|website=www.irbbarcelona.org|accessdate=31 August 2017|language=en}}
4. ^1 Elizabath Davita-Raeburn for the HHMI Bulletin. August 2008. [https://web.archive.org/web/20120905041353/http://www.hhmi.org/bulletin/aug2008/pdf/Scientist.pdf The Unintentional Scientist]
5. ^{{cite web|title=Scientific Review Board|url=http://www.hhmi.org/about/leadership/scientific-review-board|website=HHMI.org|accessdate=15 June 2017|language=en}}
6. ^ , Memorial Sloan Kettering Cancer Center.
7. ^{{cite journal|last1=Shi|first1=Y|last2=Massagué|first2=J|title=Mechanisms of TGF-beta signaling from cell membrane to the nucleus.|journal=Cell|date=13 June 2003|volume=113|issue=6|pages=685–700|pmid=12809600|accessdate=|issn=0092-8674}}
8. ^{{cite journal|last1=Siegel|first1=P. M.|last2=Shu|first2=W.|last3=Cardiff|first3=R. D.|last4=Muller|first4=W. J.|last5=Massague|first5=J.|title=Transforming growth factor signaling impairs Neu-induced mammary tumorigenesis while promoting pulmonary metastasis|journal=Proceedings of the National Academy of Sciences|date=13 June 2003|volume=100|issue=14|pages=8430–8435|doi=10.1073/pnas.0932636100|pmid=12808151|accessdate=|pmc=166246}}
9. ^{{cite journal|last1=Kang|first1=Y|last2=Siegel|first2=PM|last3=Shu|first3=W|last4=Drobnjak|first4=M|last5=Kakonen|first5=SM|last6=Cordón-Cardo|first6=C|last7=Guise|first7=TA|last8=Massagué|first8=J|title=A multigenic program mediating breast cancer metastasis to bone.|journal=Cancer Cell|date=June 2003|volume=3|issue=6|pages=537–49|pmid=12842083|accessdate=}}
10. ^{{cite journal|last1=Minn|first1=AJ|last2=Gupta|first2=GP|last3=Siegel|first3=PM|last4=Bos|first4=PD|last5=Shu|first5=W|last6=Giri|first6=DD|last7=Viale|first7=A|last8=Olshen|first8=AB|last9=Gerald|first9=WL|last10=Massagué|first10=J|title=Genes that mediate breast cancer metastasis to lung.|journal=Nature|date=28 July 2005|volume=436|issue=7050|pages=518–24|pmid=16049480|pmc=1283098|accessdate=|doi=10.1038/nature03799}}
11. ^{{cite journal|last1=Nguyen|first1=Don X.|last2=Chiang|first2=Anne C.|last3=Zhang|first3=Xiang H.-F.|last4=Kim|first4=Juliet Y.|last5=Kris|first5=Mark G.|last6=Ladanyi|first6=Marc|last7=Gerald|first7=William L.|last8=Massagué|first8=Joan|title=WNT/TCF Signaling through LEF1 and HOXB9 Mediates Lung Adenocarcinoma Metastasis|journal=Cell|date=July 2009|volume=138|issue=1|pages=51–62|doi=10.1016/j.cell.2009.04.030|pmid=19576624|pmc=2742946|accessdate=}}
12. ^{{cite journal|last1=Bos|first1=Paula D.|last2=Zhang|first2=Xiang H.-F.|last3=Nadal|first3=Cristina|last4=Shu|first4=Weiping|last5=Gomis|first5=Roger R.|last6=Nguyen|first6=Don X.|last7=Minn|first7=Andy J.|last8=van de Vijver|first8=Marc J.|last9=Gerald|first9=William L.|last10=Foekens|first10=John A.|last11=Massagué|first11=Joan|title=Genes that mediate breast cancer metastasis to the brain|journal=Nature|date=6 May 2009|volume=459|issue=7249|pages=1005–1009|doi=10.1038/nature08021|pmid=19421193|accessdate=|pmc=2698953}}
13. ^{{cite journal|last1=Kim|first1=Mi-Young|last2=Oskarsson|first2=Thordur|last3=Acharyya|first3=Swarnali|last4=Nguyen|first4=Don X.|last5=Zhang|first5=Xiang H.-F.|last6=Norton|first6=Larry|last7=Massagué|first7=Joan|title=Tumor Self-Seeding by Circulating Cancer Cells|journal=Cell|date=December 2009|volume=139|issue=7|pages=1315–1326|doi=10.1016/j.cell.2009.11.025|pmid=20064377|pmc=2810531|accessdate=}}
14. ^{{cite journal|last1=Valiente|first1=Manuel|last2=Obenauf|first2=Anna C.|last3=Jin|first3=Xin|last4=Chen|first4=Qing|last5=Zhang|first5=Xiang H.-F.|last6=Lee|first6=Derek J.|last7=Chaft|first7=Jamie E.|last8=Kris|first8=Mark G.|last9=Huse|first9=Jason T.|last10=Brogi|first10=Edi|last11=Massagué|first11=Joan|title=Serpins Promote Cancer Cell Survival and Vascular Co-Option in Brain Metastasis|journal=Cell|date=February 2014|volume=156|issue=5|pages=1002–1016|doi=10.1016/j.cell.2014.01.040|pmid=24581498|pmc=3988473|accessdate=}}
15. ^{{cite journal|last1=Malladi|first1=Srinivas|last2=Macalinao|first2=Danilo G.|last3=Jin|first3=Xin|last4=He|first4=Lan|last5=Basnet|first5=Harihar|last6=Zou|first6=Yilong|last7=de Stanchina|first7=Elisa|last8=Massagué|first8=Joan|title=Metastatic Latency and Immune Evasion through Autocrine Inhibition of WNT|journal=Cell|date=March 2016|volume=165|issue=1|pages=45–60|doi=10.1016/j.cell.2016.02.025|pmid=27015306|pmc=4808520|accessdate=}}
16. ^{{cite web|title=Joan Massagué, PhD, to Receive 2016 Pezcoller Foundation–AACR International Award for Cancer Research|url=http://www.ascopost.com/issues/april-10-2016/joan-massagu%C3%A9-phd-to-receive-2016-pezcoller-foundation-aacr-international-award-for-cancer-research/|website=The ASCO Post|accessdate=19 April 2017}}
17. ^{{cite web|title=Joan Massagué, PhD|url=http://www.aacr.org/Membership/Pages/FellowDetailsNoModal.aspx?ItemID=166|accessdate=19 April 2017}}
18. ^{{cite web|title=Brupbacher Preis|url=http://brupbacher-foundation.org/en/awards/brupbacher-prize/|website=Charles Rodolphe Brupbacher Stiftung|accessdate=19 April 2017|language=fr|date=6 February 2017}}
19. ^{{cite web|title=Professor Peter Ratcliffe receives Pasarow Award in Cardiovascular Disease - Nuffield Department of Medicine|url=https://www.ndm.ox.ac.uk/professor-peter-ratcliffe-receives-pasarow-award-in-cardiovascular-disease|website=www.ndm.ox.ac.uk|accessdate=19 April 2017}}
20. ^{{Cite web|url=http://www.fbbva.es/TLFU/tlfu/ing/microsites/premios/fronteras/galardonados/2008/biomedicina.jsp|title=BBVA Foundation Frontiers of Knowledge Awards|website=www.fbbva.es|access-date=2016-07-04}}
21. ^{{cite web|title=Past Recipients - The Passano Foundation, Inc.|url=http://passanofoundation.org/past-recipients/4513087930|website=passanofoundation.org|accessdate=6 April 2017|language=en}}
22. ^{{Cite web|title = Joan Massagué Wins Vilcek Prize {{!}} Memorial Sloan Kettering Cancer Center|url = https://www.mskcc.org/blog/joan-massague-wins-vilcek-prize|website = www.mskcc.org|accessdate = 2015-11-11}}
23. ^{{cite web|title=Member|url=https://nam.edu/member/?member_id=iEPPs%2FWykTZ0wiogkl8PVw%3D%3D|website=National Academy of Medicine|accessdate=17 May 2017}}
24. ^{{cite web|title=Judah Folkman, Tony Hunter, Joan Massagué, Bert Vogelstein and Robert A. Weinberg - Laureates - Princess of Asturias Awards - The Princess of Asturias Foundation|url=http://www.fpa.es/en/princess-of-asturias-awards/laureates/2004-judah-folkman-tony-hunter-joan-massague-bert-vogelstein-and-robert-a-weinberg.html?especifica=0|website=The Princess of Asturias Foundation|accessdate=6 April 2017}}
25. ^{{cite web|last1=http://www.nasonline.org|first1=National Academy of Sciences -|title=Joan Massague|url=http://www.nasonline.org/member-directory/members/2541117.html|website=www.nasonline.org|accessdate=17 May 2017}}
26. ^{{cite web|title=Academy of Arts & Sciences Website Search|url=https://www.amacad.org/content/system/search.aspx?s=joan+massague#srConstOverview|website=www.amacad.org|accessdate=17 May 2017}}
{{Authority control}}{{DEFAULTSORT:Massague, Joan}}

14 : 1953 births|Catalan scientists|Living people|Members of the United States National Academy of Sciences|Members of the National Academy of Medicine|Spanish medical researchers|Cancer researchers|People from Barcelona|University of Barcelona alumni|Brown University fellows|Howard Hughes Medical Investigators|Fellows of the AACR Academy|Cornell University faculty|Fellows of the American Academy of Arts and Sciences
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